Photo by Catherine Edejer-McCormick

Find 5 Star Hotels in South San Francisco, CA from $168

Compare South San Francisco 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Fairmont San Francisco
Terrace/patio
Fairmont San Francisco
5.0 star property
8.6 out of 10, Excellent, 1,022 reviews
"Just a beautiful hotel with amazing views. Loved it!!"
The price is $242
$323 total
includes taxes & fees
Jun 16 - Jun 17
Fairmont San Francisco
Palace Hotel, a Luxury Collection Hotel, San Francisco
Property amenity
Palace Hotel, a Luxury Collection Hotel, San Francisco
5.0 star property
9.0 out of 10, Wonderful, 1,007 reviews
"Beautiful Hotel! Lots of historic items to see and learn more about. Valet parking staff was very helpful and friendly. Hotel was clean and we felt safe. "
The price is $220
$257 total
includes taxes & fees
Jun 30 - Jul 1
Palace Hotel, a Luxury Collection Hotel, San Francisco
Taj Campton Place
City view
Taj Campton Place
5.0 star property
9.2 out of 10, Wonderful, 1,006 reviews
"Very relaxing "
The price is $168
$231 total
includes taxes & fees
Jun 14 - Jun 15
Taj Campton Place
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The Ritz-Carlton, San Francisco
Club Suite, 1 Bedroom, Non Smoking | 1 bedroom, Frette Italian sheets, premium bedding, in-room safe
The Ritz-Carlton, San Francisco
5.0 star property
9.2 out of 10, Wonderful, 1,002 reviews
"Staff was all great, friendly and helpful. Great spot for walking around Chinatown. While you can see some stuff a couple blocks away towards Union Square we never felt unsafe."
The price is $370
$433 total
includes taxes & fees
Jun 20 - Jun 21
The Ritz-Carlton, San Francisco
Claremont Club & Spa - A Fairmont Hotel
Exterior
Claremont Club & Spa - A Fairmont Hotel
5.0 star property
8.8 out of 10, Excellent, 1,007 reviews
"It is one of the most spectacular buildings on the West Coast, built mainly of wood in the 1910s, with a fantastic view of SF and the Bay. It is also an excellent location for exploring the Berkeley hills and the East Bay."
The price is $251
$345 total
includes taxes & fees
Jun 9 - Jun 10
Claremont Club & Spa - A Fairmont Hotel
1 Hotel San Francisco
Gift shop
1 Hotel San Francisco
5.0 star property
9.2 out of 10, Wonderful, 234 reviews
"What we loved: - Stylish and modern design - Overall hotel vibe - Great amenities in the room What we didn't like: - No buffet breakfast option - The minibar in our room had some dust on the items - Bar was out of my fav beer"
The price is $305
$409 total
includes taxes & fees
Jun 22 - Jun 23
1 Hotel San Francisco
Four Seasons Hotel San Francisco
Terrace/patio
Four Seasons Hotel San Francisco
5.0 star property
9.4 out of 10, Exceptional, 908 reviews
"Like that it has equinox "
The price is $415
$484 total
includes taxes & fees
Jun 14 - Jun 15
Four Seasons Hotel San Francisco
Four Seasons Hotel Silicon Valley at East Palo Alto
Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
Four Seasons Hotel Silicon Valley at East Palo Alto
5.0 star property
9.4 out of 10, Exceptional, 549 reviews
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The price is $316
$359 total
includes taxes & fees
Jul 5 - Jul 6
Four Seasons Hotel Silicon Valley at East Palo Alto
The St. Regis San Francisco
Exterior
The St. Regis San Francisco
5.0 star property
9.4 out of 10, Exceptional, 608 reviews
"Beautiful hotel. Great service. Great food and drinks. "
The price is $428
$499 total
includes taxes & fees
Jun 21 - Jun 22
The St. Regis San Francisco
Rosewood Sand Hill
Couples treatment rooms, sauna, spa tub, body treatments, hydrotherapy
Rosewood Sand Hill
5.0 star property
9.4 out of 10, Exceptional, 198 reviews
"Very nice property. Service is excellent "
The price is $1,040
$1,235 total
includes taxes & fees
Jul 6 - Jul 7
Rosewood Sand Hill
Nobu Hotel Palo Alto
Meeting facility
Nobu Hotel Palo Alto
5.0 star property
9.2 out of 10, Wonderful, 354 reviews
"It was simple and stylish. Very best of Japanese culture."
The price is $395
$457 total
includes taxes & fees
Jun 21 - Jun 22
Nobu Hotel Palo Alto
The Ritz-Carlton, Half Moon Bay
Egyptian cotton sheets, premium bedding, down comforters, in-room safe
The Ritz-Carlton, Half Moon Bay
5.0 star property
9.0 out of 10, Wonderful, 587 reviews
"The Ocean view and the golf course view were fantastic. The walking trail is also nice. Golfers have access to Half Moon Bay Golf Links golf courses. The Ocean course is enjoyable. "
The price is $829
$1,040 total
includes taxes & fees
Jun 23 - Jun 24
The Ritz-Carlton, Half Moon Bay
Hotel Drisco
City view
Hotel Drisco
5.0 star property
9.8 out of 10, Exceptional, 395 reviews
"I felt like a princess! This hotel is first class from start to finish. The rooms are appointed nicely, so comfy and clean. Every staff member I met was exceptionally nice and attentive. I really didn't want to leave! Such a wonderful find and made our trip to San Francisco very special. Cannot recommend enough. "
The price is $467
$539 total
includes taxes & fees
Jul 1 - Jul 2
Hotel Drisco
Mansion on Sutter
Front of property
Mansion on Sutter
5.0 star property
9.4 out of 10, Exceptional, 152 reviews
"Amazing staff. Very friendly. They even make espresso and latte. Lobby is beautiful. It’s like a gallery of arts. Very relaxing environment. Location may be the best in the city. "
The price is $261
$332 total
includes taxes & fees
Jun 17 - Jun 18
Mansion on Sutter
Fairmont Heritage Place, Ghirardelli Square
Exterior
Fairmont Heritage Place, Ghirardelli Square
5.0 star property
9.4 out of 10, Exceptional, 348 reviews
"I gave it 5 stars cause I couldn’t give more."
The price is $1,055
$1,229 total
includes taxes & fees
Jun 13 - Jun 14
Fairmont Heritage Place, Ghirardelli Square
Dimond Abode Vacation Rental 3428
Terrace/patio
Dimond Abode Vacation Rental 3428
5.0 star property
10.0 out of 10, Exceptional, 3 reviews
"Wonderful place to stay! Host was great and the place was clean. Nice neighborhood, safe, and right near a good gas station. Will definitely stay next time I go back to Oakland."
Dimond Abode Vacation Rental 3428

Ready for an incredible adventure? Add even more pleasure on your next trip to South San Francisco by treating yourself to the best of the best when it comes to accommodation. It's an ideal fusion. After all, you love the finer things in life, both at home and when you book a getaway. You'll join the multitudes of vacationers who have made South San Francisco so popular in the last year. There's no reason to delay a getaway to South San Francisco any longer. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. Book one of Expedia's luxurious 5-star hotels in South San Francisco and get ready to be pampered like never before. Don't wait any longer!

Get a Great Deal on 5-Star Hotels in South San Francisco

You can expect high quality from your hotel. Spa treatments, delicious meals, and attentive guest service are all at your fingertips. You're sure to find exactly the accommodation you need. You'll be pleased to note that the hotels in South San Francisco offer great customer service, averaging 3.7 in our ranking system, giving you a lot to look forward to. What creature comforts do you want in your lodging? A rejuvenating facial treatment to help your cares fall away? A concierge to help you suggest the next attraction to visit? High thread-count sheets, piping hot coffees, and even spectacular views...these hotels are one-of-a-kind.

Can't wait to get outside? We hear you. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what's on your agenda, the 5-star hotels in South San Francisco are waiting for you to rest up after a busy day. Ready to learn more? Then explore the 1,590 reviews various guests have left on Expedia and get to know these places.

Make Your Escape

The results are in, and South San Francisco 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Decide on one of Expedia's South San Francisco 5-star hotels today and soothe yourself in complete comfort tomorrow.

Frequently asked questions

What are the best 5-star hotels in South San Francisco?
The St. Regis San Francisco, Four Seasons Hotel San Francisco and Mansion on Sutter are among the best 5-star hotels in South San Francisco, according to our traveler reviews. These upscale hotels rate highly for things like their location, conveniences and guest services. Pick your favorite and experience the best of everything.
How much does it cost to stay in a 5-star hotel in South San Francisco?
The amount you pay for a 5-star hotel in South San Francisco depends on things such as when you plan to go and the length of your break. Our insider tip for bagging the best deal? Use our pricing filters to compare the available hotels for your chosen dates.

  • Search for the lowest price per night from $168

What makes a hotel 5 stars in South San Francisco?
In South San Francisco, a hotel must provide a certain number of upscale amenities to be designated 5 stars. These may include on-site gyms, saunas and spas, gourmet restaurants, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their outstanding standard of service. You can look forward to things like concierge services, in-room massages and nightly turn-down services. Some may also offer thoughtful touches like welcome gifts.
Are there any 5-star all-inclusive resorts in South San Francisco?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in South San Francisco with the help of Expedia’s filter tool. Search for hotels with a 5-star rating and select the “All inclusive” filter. Make sure you check what’s included in the price. This way, you’re ready to take advantage of the many perks on offer from the moment you arrive.
What are the top 5-star spa hotels in South San Francisco?
Four Seasons Hotel San Francisco combines plush accommodations with blissful wellness therapies and experiences. Choose from a menu of facials, massages and more at this well-known 5-star spa retreat in South San Francisco.
Are there any 5-star vacation rentals in South San Francisco?
Our site doesn’t have any 5-star vacation rentals in South San Francisco. However, you will still find a few top-rated options where the only thing on your agenda will be to relax and have fun. See what’s available by searching through our vacation rentals in South San Francisco.