Find 5 Star Hotels in Syracuse from $136

Check availability on Syracuse 5 Star Hotels

Compare Syracuse 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

"Great location and staff. Food excellent at La Terasse and at breakfast."

$325 total

includes taxes & fees

Jun 2 - Jun 3

Minibar, in-room safe, desk, laptop workspace

"Every thing is perfect "

$522 total

includes taxes & fees

Jun 16 - Jun 17

"Location: Excellent, on Ortigia island but close to mainland. Near open air market & many good restaurants. Facilities: Common areas are superb & luxurious. Room is OK, not great. Bathroom too small, especially shower, which also leaks after each use. Service: At breakfast, service is excellent. Housekeeping is OK, sometimes good, sometimes a bit off. Food: Judging from breakfast, restaurant probably very good. In conclusion: If the bathroom was larger and better, it would truly be a 5-star...

$409 total

includes taxes & fees

Jun 5 - Jun 6

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"Wonderful hotel to stay in. Stayed in our own little guest house with everything you need inside. Nicely decorated comfortable and clean. Breakfast was top notch as was the service. Would stay with them again without hesitation "

$237 total

includes taxes & fees

Jun 13 - Jun 14

Private beach nearby, sun loungers, beach umbrellas, beach towels

"Amazing pool and beaches. "

$496 total

includes taxes & fees

Jun 1 - Jun 2

$365 total

includes taxes & fees

May 29 - May 30

"lovely peaceful area, great breakfast, very nice pool area"

$166 total

includes taxes & fees

Jun 6 - Jun 7

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93, Syracuse, SR

$402

$454 total

includes taxes & fees

Jun 2 - Jun 3

9.4/10 Exceptional! (685 reviews)

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Pool Spa Hot tub Breakfast included Waterpark

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

You enjoy the finer things in life, both at home and on vacation. Treat your every whim on your upcoming break. There's no reason to delay a getaway to Syracuse any longer. You'll join the multitudes of vacationers who have made Syracuse so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve an outstanding getaway. Book one of Expedia's luxurious 5-star hotels in Syracuse and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Syracuse

You'll have a wonderful time at one of these 5-star hotels. Highly-rated eateries, concierges, and in-room spa sessions are all at the ready. You're sure to find exactly the accommodation you need. You can also expect excellent customer service from these hotels, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A deep-tissue massage to help your cares fall away? A concierge to help you plan every detail of your day? Fluffy down pillows, lip-smacking main courses, and even space for your family pet in some cases...these hotels are one-of-a-kind.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. Whatever you plan to do, the 5-star hotels in Syracuse are the perfect place to relax after an exciting day. Ready to learn more? Then check out our listings and pick the perfect accommodation for your needs.

Make Your Escape

The results are in, and Syracuse 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Select one of Expedia's Syracuse 5-star hotels today and relax in luxe surroundings tomorrow.

Frequently asked questions

What are the best 5-star hotels in Syracuse?

Prepare for 5-star opulence at Grand Hotel Ortigia Siracusa, Ortea Palace, Sicily, Autograph Collection or Grand Hotel Des Ètrangers. These are some of the best stays in Syracuse based on Expedia customer reviews. Book one and get a taste of the finer life!

How much does it cost to stay in a 5-star hotel in Syracuse?

How much you pay for a 5-star hotel in Syracuse depends on factors like when you plan to go and the length of your vacation. Our insider tip for bagging the best deal? Use our pricing filters to compare all of the available hotels for your preferred dates.

Search for the lowest price per night from $136

What makes a hotel 5 stars in Syracuse?

From high-end restaurants and fitness centers to swimming pools and superior bedding, the 5-star experience in Syracuse is all about luxury and relaxation. But it calls for more than just upscale amenities to get a 5-star rating. Hotels also have to deliver outstanding guest services like massage treatments, laundry and dry cleaning and 24-hour room service.

Are there any 5-star all-inclusive resorts in Syracuse?

Our filter tool is the easiest way to find exactly what you want. Select “5-star” and “All inclusive” to show the most luxurious properties in Syracuse where your accommodations, meals, activities and entertainment are included in the price. At these retreats, your vacation is pure extravagance from the moment you check in.

What are the top 5-star spa hotels in Syracuse?

Syracuse has a range of 5-star spa accommodations that offer therapies designed to revitalize both the mind and body. Spend your next vacation at Minareto, Ortea Palace, Sicily, Autograph Collection or Grand Hotel Ortigia Siracusa and prioritize your health and well-being.

Are there any 5-star vacation rentals in Syracuse?

You won’t find any 5-star vacation rentals in Syracuse on our site, but there are a few other highly rated properties worth checking out. Browse our vacation rentals in Syracuse to book the perfect place for your stay.

Are there any 5-star hotels in downtown Syracuse?

Book a room at Grand Hotel Ortigia Siracusa. This 5-star hotel is an excellent option if you want to experience Syracuse’s exciting downtown scene.

Recent reviews of Syracuse hotels
Expedia verified reviews

5/5 Excellent

"Every thing is perfect "

A verified traveler stayed at Grand Hotel Des Ètrangers

Posted 2 weeks ago

Wellness & Spa Hotel Principe di Fitalia

5/5 Excellent

The Best ever

"This is probably the best hotel my husband and I have ever stayed. I have written many reviews and never have I ever had the pleasure to write such a glowing compliment about a place we have stayed . We spent only one night here, but we have been overwhelmed by the hospitality of the hotel staff . We were greeted by Giuseppe at the front desk who upgraded us to a suite and very kind. The room had the view of the front garden and swimming pool- it felt serene. The bathroom had great selection of toiletries and the shower was very comfortable. We went to the spa which is honestly spectacular . We took the hammam treatment and Paulo did a great job . He informed us that he has been working in this spa for over 10 years and really takes care of the spa like it’s his own . Then we had dinner at the hotel restaurant and we were blown away by the hospitality of the chef’s team and Santoni our server. Every dish was meticulously prepared and they really took care of us with no compromise of service and flavour. The stuffed ravioli was a taste sensatio. The breakfast was yet another spectacular event. The hot eggs and pastries were exquisite and Jimmy our server was kind and attentive and took initiative really look after us. Isobella at the reception was lovely .The thing we took away from staying here 1 night is that the staff love their job and it is because of this dedication to attention & professionalism in every tiny detail that makes this the best hotel we have ever stayed."

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Find 5 Star Hotels in Syracuse from $136

Check availability on Syracuse 5 Star Hotels

Compare Syracuse 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Grand Hotel Ortigia Siracusa

Grand Hotel Des Ètrangers

Ortea Palace Hotel, Sicily, Autograph Collection

Caportigia Boutique Hotel

Minareto

Wellness & Spa Hotel Principe di Fitalia

Borgo di Luce - I Monasteri Golf Resort & SPA