Find 5 Star Hotels in Mission District, CA from $135

Compare Mission District 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Fairmont San Francisco
Terrace/patio
Fairmont San Francisco
5.0 star property
8.6 out of 10, Excellent, (1024)
"Nice view and centrally located"
The price is $242
$323 total
includes taxes & fees
Jun 16 - Jun 17
Fairmont San Francisco
Palace Hotel, a Luxury Collection Hotel, San Francisco
Property amenity
Palace Hotel, a Luxury Collection Hotel, San Francisco
5.0 star property
9.0 out of 10, Wonderful, (1009)
"Beautiful Hotel! Lots of historic items to see and learn more about. Valet parking staff was very helpful and friendly. Hotel was clean and we felt safe. "
The price is $220
$257 total
includes taxes & fees
Jun 30 - Jul 1
Palace Hotel, a Luxury Collection Hotel, San Francisco
Taj Campton Place
City view
Taj Campton Place
5.0 star property
9.2 out of 10, Wonderful, (1006)
"Very relaxing "
The price is $168
$231 total
includes taxes & fees
Jun 16 - Jun 17
Taj Campton Place
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The Ritz-Carlton, San Francisco
Club Suite, 1 Bedroom, Non Smoking | 1 bedroom, Frette Italian sheets, premium bedding, in-room safe
The Ritz-Carlton, San Francisco
5.0 star property
9.2 out of 10, Wonderful, (1002)
"Staff was all great, friendly and helpful. Great spot for walking around Chinatown. While you can see some stuff a couple blocks away towards Union Square we never felt unsafe."
The price is $370
$432 total
includes taxes & fees
Jun 16 - Jun 17
The Ritz-Carlton, San Francisco
Claremont Club & Spa - A Fairmont Hotel
Exterior
Claremont Club & Spa - A Fairmont Hotel
5.0 star property
8.8 out of 10, Excellent, (1008)
"Love the Claremont "
The price is $251
$345 total
includes taxes & fees
Jun 9 - Jun 10
Claremont Club & Spa - A Fairmont Hotel
1 Hotel San Francisco
Gift shop
1 Hotel San Francisco
5.0 star property
9.2 out of 10, Wonderful, (234)
"What we loved: - Stylish and modern design - Overall hotel vibe - Great amenities in the room What we didn't like: - No buffet breakfast option - The minibar in our room had some dust on the items - Bar was out of my fav beer"
The price is $329
$436 total
includes taxes & fees
Jun 9 - Jun 10
1 Hotel San Francisco
Four Seasons Hotel San Francisco
Terrace/patio
Four Seasons Hotel San Francisco
5.0 star property
9.4 out of 10, Exceptional, (909)
"Like that it has equinox "
The price is $415
$484 total
includes taxes & fees
Jun 15 - Jun 16
Four Seasons Hotel San Francisco
Four Seasons Hotel San Francisco at Embarcadero
Rooftop terrace
Four Seasons Hotel San Francisco at Embarcadero
5.0 star property
9.4 out of 10, Exceptional, (1003)
"This was an excellent hotel. Bar was great, staff were very friendly, and the views were spectacular. Or is also quite convenient for touring the city. "
The price is $415
$484 total
includes taxes & fees
Jun 15 - Jun 16
Four Seasons Hotel San Francisco at Embarcadero
The St. Regis San Francisco
Exterior
The St. Regis San Francisco
5.0 star property
9.4 out of 10, Exceptional, (608)
"Beautiful hotel. Great service. Great food and drinks. "
The price is $428
$499 total
includes taxes & fees
Jun 21 - Jun 22
The St. Regis San Francisco
Hotel Drisco
City view
Hotel Drisco
5.0 star property
9.8 out of 10, Exceptional, (396)
"I felt like a princess! This hotel is first class from start to finish. The rooms are appointed nicely, so comfy and clean. Every staff member I met was exceptionally nice and attentive. I really didn't want to leave! Such a wonderful find and made our trip to San Francisco very special. Cannot recommend enough. "
The price is $485
$559 total
includes taxes & fees
Jul 1 - Jul 2
Hotel Drisco
Mansion on Sutter
Front of property
Mansion on Sutter
5.0 star property
9.4 out of 10, Exceptional, (152)
"Amazing staff. Very friendly. They even make espresso and latte. Lobby is beautiful. It’s like a gallery of arts. Very relaxing environment. Location may be the best in the city. "
The price is $261
$332 total
includes taxes & fees
Jun 16 - Jun 17
Mansion on Sutter
Fairmont Heritage Place, Ghirardelli Square
Exterior
Fairmont Heritage Place, Ghirardelli Square
5.0 star property
9.4 out of 10, Exceptional, (348)
"I gave it 5 stars cause I couldn’t give more."
The price is $1,055
$1,229 total
includes taxes & fees
Jun 30 - Jul 1
Fairmont Heritage Place, Ghirardelli Square
Dimond Abode Vacation Rental 3428
Terrace/patio
Dimond Abode Vacation Rental 3428
5.0 star property
10.0 out of 10, Exceptional, (3)
"Wonderful place to stay! Host was great and the place was clean. Nice neighborhood, safe, and right near a good gas station. Will definitely stay next time I go back to Oakland."
Dimond Abode Vacation Rental 3428

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mission District.
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

2500 Mason St, San Francisco, CA
The price is $139 per night from Jun 30 to Jul 1
$139
$196 total
includes taxes & fees
Jun 30 - Jul 1
8.6/10 Excellent! (6,305 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

There's nothing wrong with enjoying the finer things in life. Add an extra layer of pleasure on your next trip to Mission District by treating yourself to the best of the best when it comes to accommodation. It's an ideal combination. There's no reason to delay a getaway to Mission District any longer. You'll join the multitudes of vacationers who have made Mission District so fashionable in the last few seasons. You can also expect excellent customer service from these hotels, so get ready to kick back and indulge. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Mission District and get ready to be pampered like never before.

5-Star Hotels in Mission District

You'll have a fantastic time at one of these 5-star hotels. Top-notch service, delicious meals, and one-on-one attention are all ready for you. You're sure to find exactly the accommodation you need. You'll also enjoy a high standard of care and meticulous guest relations, so get ready for a wonderful adventure. What kind of amenities will make your stay a wonderful one? A rejuvenating facial treatment to help your cares fall away? A concierge to help you pick out your next adventure? Plush carpeting, delectable chocolate desserts, and even a hot tub in the bathroom...these hotels will leave you amazed. Want to see for yourself? Explore our listings and pick the perfect accommodation for your needs.

Can't wait to get outside? We've got you covered. From doing a bit of shopping to embracing the great outdoors, you'll never be bored on this retreat. No matter what you end up doing, the 5-star hotels in Mission District are the perfect place to relax after a busy day.

Make Your Escape

The results are in, and Mission District 5-star hotels are the place to be when you book your next vacation. If you've been dreaming about a vacation set here, then go ahead and book it. Expedia can help you land a great deal on accommodation. Don't put off your dream vacation any longer. Choose one of Expedia's Mission District 5-star hotels today and decompress in the lap of luxury tomorrow.

Frequently asked questions

What are the best 5-star hotels in Mission District?
Based on reviews by our travelers, Mansion on Sutter is one of the leading retreats for an indulgent getaway in the San Francisco neighborhood of Mission District. Looking for more 5-star hotels around the area? Four Seasons Hotel San Francisco and The St. Regis San Francisco will meet your high-end desires.
How much does it cost to stay in a 5-star hotel in Mission District?
How much you pay for a 5-star hotel in Mission District can vary depending on when you decide to travel and how long you plan to stay, among other factors. Take advantage of our price per night filter and other search tools to score the best deal on a high-end getaway.

  • Search for the lowest price per night from $135

What makes a hotel 5 stars in Mission District?
Outstanding guest service characterizes every 5-star hotel in Mission District. From the minute you arrive, staff cater to your every need, whether recommending activities and tours or providing in-room massages. Additionally, hotels have to offer top-rate amenities to be eligible for a 5-star rating. These can include luxury bath products, spas or saunas, swimming pools, fine dining kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Mission District?
Expedia’s filters are the quickest way to narrow down what you’re looking for. Select “All inclusive” and “5-star” to show the finest properties in Mission District where your meals, accommodations, entertainment and activities are included in the price. At these getaways, your vacation is pure extravagance from the moment you enter the lobby.
What are the top 5-star spa hotels in Mission District?
Enjoy a respite from the rigors of daily life at one of our 5-star spa properties in or around Mission District. Standout options are 1 Hotel San Francisco, Fairmont San Francisco and Four Seasons Hotel San Francisco. Select from a menu of relaxing treatments and therapeutic services tailored to enhance your overall well-being.
Are there any 5-star vacation rentals in Mission District?
Our site doesn’t offer any 5-star vacation rentals in Mission District. However, you can still find some top-rated options where the only thing on your itinerary will be to unpack and enjoy yourself. Discover what’s available by searching through our vacation rentals in Mission District.