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Quality Inn Cairo I-57
Quality Inn Cairo I-57
6.6 out of 10, 224 reviews
The price is $75
$83 total
includes taxes & fees
Jun 9 - Jun 10
Cozy cabins on beautiful Horseshoe Lake
Cozy cabins on beautiful Horseshoe Lake
9.8 out of 10, Exceptional, 19 reviews
The price is $115
$135 total
includes taxes & fees
Jun 9 - Jun 10
The Rested Duck Mallard Room
The Rested Duck Mallard Room
8.8 out of 10, Excellent, 15 reviews
The price is $115
$143 total
includes taxes & fees
Jun 9 - Jun 10
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Super 8 by Wyndham Charleston/Sikeston East MO
Super 8 by Wyndham Charleston/Sikeston East MO
6.8 out of 10, 501 reviews
The price is $63
$70 total
includes taxes & fees
Jul 7 - Jul 8
Eagle Inn Charleston
Eagle Inn Charleston
6.8 out of 10, 93 reviews
The price is $70
$78 total
includes taxes & fees
Jun 9 - Jun 10
Quality Inn - Sikeston
Quality Inn - Sikeston
6.8 out of 10, 327 reviews
The price is $63
$70 total
includes taxes & fees
Jun 16 - Jun 17
La Center Motel
La Center Motel
6.0 out of 10, 3 reviews
The price is $57
$67 total
includes taxes & fees
Jun 9 - Jun 10
Solar Eclipse Festival at our Campground at Benton Speedway. April 6-8th 2024.
Solar Eclipse Festival at our Campground at Benton Speedway. April 6-8th 2024.
The price is $40
$60 total
includes taxes & fees
Jun 9 - Jun 10
Solar Eclipse Festival Campground at Benton Speedway. April 6-8th 2024.
Solar Eclipse Festival Campground at Benton Speedway. April 6-8th 2024.
10.0 out of 10, Exceptional, 1 review
Days Inn and Suites by Wyndham Sikeston
Days Inn and Suites by Wyndham Sikeston
7.0 out of 10, Good, 1,010 reviews
The price is $69
$78 total
includes taxes & fees
Jun 16 - Jun 17
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MO
9.4 out of 10, Exceptional, 1,008 reviews
The price is $99
$112 total
includes taxes & fees
Jun 16 - Jun 17
Beautiful Cabin Retreat
Beautiful Cabin Retreat
8.2 out of 10, Very Good, 39 reviews
The price is $120
$193 total
includes taxes & fees
Jun 9 - Jun 10
Pear Tree Inn Sikeston
Pear Tree Inn Sikeston
9.4 out of 10, Exceptional, 1,010 reviews
The price is $94
$108 total
includes taxes & fees
Jun 16 - Jun 17
Best Western Plus Sikeston
Best Western Plus Sikeston
8.4 out of 10, Very Good, 1,010 reviews
The price is $94
$106 total
includes taxes & fees
Jun 9 - Jun 10
Travel Inn & Suites
Travel Inn & Suites
8.4 out of 10, Very Good, 527 reviews
The price is $59
$68 total
includes taxes & fees
Jul 2 - Jul 3
Country Yard Inn and Suite
Country Yard Inn and Suite
7.4 out of 10, Good, 34 reviews
The price is $58
$69 total
includes taxes & fees
Jun 9 - Jun 10
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
10.0 out of 10, Exceptional, 140 reviews
Comfort Inn & Suites Sikeston I-55
Comfort Inn & Suites Sikeston I-55
8.4 out of 10, Very Good, 199 reviews
The price is $93
$106 total
includes taxes & fees
Jun 9 - Jun 10
Charming cottage overlooking Lake Acre
Charming cottage overlooking Lake Acre
10.0 out of 10, Exceptional, 84 reviews
The price is $150
$256 total
includes taxes & fees
Jun 9 - Jun 10
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Sikeston/Miner Area
6.4 out of 10, 475 reviews
The price is $60
$68 total
includes taxes & fees
Jun 16 - Jun 17
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Recent reviews of Cairo Regional hotelsExpedia verified reviews
5/5 Excellent
"The front desk was really nice. My room had a roach in it and she moved me."
A verified traveler stayed at Pear Tree Inn Sikeston
Posted 3 days ago
Hotels Close to Nearby Airports
Hotels near popular Cairo Attractions
- Shawnee National Forest
- Mississippi River
- Ohio River
- Southeast Missouri State University
- Isle Casino Cape Girardeau
- Riverfront Bridge Park
- Columbus-Belmont State Park
- The Book Bug
- Cape Rock Park
- Henry N Barkhausen Cache River Wetlands Center
- Riverfront Park
- Fort Defiance State Park
- eDen Spa & Salon
- Sikeston Depot Museum
- Ullin City Hall
- Fort D Historic Site
- Shawnee Community College
- Mound City National Cemetery
- Central Park
- Ballard Wildlife Management Area
Hotel options around Cairo Regional
- Drury Inn & Suites Sikeston, MO
- Beautiful Cabin Retreat
- Pear Tree Inn Sikeston
- Best Western Plus Sikeston
- Travel Inn & Suites
- Country Yard Inn and Suite
- Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
- Comfort Inn & Suites Sikeston I-55
- Charming cottage overlooking Lake Acre
- Super 8 by Wyndham Sikeston/Miner Area
- Courtyard by Marriott Cape Girardeau Downtown
- Charming Home just minutes from Interstate and Mall
- Stylish chalet style home
- Beautiful newly renovated farm house overlooking 5 acre lake. ****New Rates ***
- Pole barn house
- Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
- Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Little Blue Cottage on Spanish
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