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Compare 206 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Cozy home. 15 minutes from the lake and 30 minutes from the beach!
10.0 out of 10, Exceptional, (2)
"Awesome host and place"
The price is $105
$232 total
includes taxes & fees
May 21 - May 22
Cozy home. 15 minutes from the lake and 30 minutes from the beach!
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
10.0 out of 10, Exceptional, (16)
"We just stayed for a night to recharge and hit the road again. It was the perfect place to rest for our family of 4 plus 2 dogs."
The price is $156
$395 total
includes taxes & fees
May 8 - May 9
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available
10.0 out of 10, Exceptional, (30)
"The condo was everything advertised and location was great when playing golf at all the local courses. Plenty of room for our group and very quiet and relaxing unit. Will definitely be back."
Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available
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Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
10.0 out of 10, Exceptional, (10)
"Nice and roomy, nice location, fast response from the host."
The price is $85
$172 total
includes taxes & fees
May 2 - May 3
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
New Lakefront Deck Home with Dock, Views
10.0 out of 10, Exceptional, (3)
"We really enjoyed it I would stay here again"
New Lakefront Deck Home with Dock, Views
Fairfield Inn & Suites by Marriott Santee
2.5 star property
9.8 out of 10, Exceptional, (981)
"This property is super clean! Great staff!"
The price is $146
$162 total
includes taxes & fees
May 29 - May 30
Fairfield Inn & Suites by Marriott Santee
Hampton Inn Santee-I-95
2.5 star property
9.6 out of 10, Exceptional, (1000)
"Great staff, very clean, large room, great location. We would stay here again!"
The price is $153
$170 total
includes taxes & fees
May 27 - May 28
Hampton Inn Santee-I-95
Executive 2 BR/2 BA Lakefront Corner Suite Condo
9.6 out of 10, Exceptional, (17)
"Beautiful view of Lake Marion. Condo was very clean and spacious. Kitchen was well equipped and bathrooms had plenty of towel, soap shampoo etc. I would highly recommend this condo."
Executive 2 BR/2 BA Lakefront Corner Suite Condo
Wyndham Vacation Resorts Lake Marion
4.0 star property
9.4 out of 10, Exceptional, (15)
"I enjoy my stay, customer service was exceptional. Will book again. "
Wyndham Vacation Resorts Lake Marion
Relax by Lake Marion - A lake home with you in mind.
9.4 out of 10, Exceptional, (58)
"The property was spotless very clean . Check in was very simple and very easy . The communication with the property manager was great !! Got right back within three minutes. Suggested things to do and I must my experience with my family was a great pleasure for all . Highly recommend. 😃"
Relax by Lake Marion - A lake home with you in mind.
Tru By Hilton Santee
2.5 star property
9.0 out of 10, Wonderful, (98)
"Pleasant environment "
The price is $123
$137 total
includes taxes & fees
May 19 - May 20
Tru By Hilton Santee
Lakefront condo with boat slip available. 3 br, 3 ba
9.0 out of 10, Wonderful, (9)
"2 TVs in the living room: one didn't work and one only got a few channels. Need to have soft, fluffy towels and a sheet of guidelines that tell what to do when checking out. Strip beds? etc."
Lakefront condo with boat slip available. 3 br, 3 ba
Best Western Plus Santee Inn
2.5 star property
8.6 out of 10, Excellent, (1000)
"Sime front desk staff indifferent attitude towards people of color. Housekeeping and breakfast servers very congenial. "
The price is $137
$152 total
includes taxes & fees
May 8 - May 9
Best Western Plus Santee Inn
Lake Life on Lake Marion/Santee SC
8.6 out of 10, Excellent, (7)
"Our reservations were canceled after we had received confirmation notice and instructions on how to enter the property. We were sent a welcome notice from the owner, but later told that the renters in the property wanted to extend their stay, so we were left out in the cold. We ended up having to rent motel rooms while waiting for our credit card to be released after we had been charged for the stay. We ended up in motel rooms for 12 nights instead of a house we had reserved."
Lake Life on Lake Marion/Santee SC
Holiday Inn Santee, an IHG Hotel
3.0 star property
8.2 out of 10, Very Good, (736)
"The staff was pleasant and helpful and the room was clean. And comfortable as I would have expected it to be from that chain."
The price is $169
$188 total
includes taxes & fees
May 2 - May 3
Holiday Inn Santee, an IHG Hotel
Comfort Inn & Suites Santee
2.5 star property
8.0 out of 10, Very Good, (834)
"Ok"
The price is $132
$147 total
includes taxes & fees
May 28 - May 29
Comfort Inn & Suites Santee
Baymont by Wyndham Santee
2.5 star property
7.8 out of 10, Good, (1318)
"Check-in clerk was super efficient and friendly. "
The price is $75
$83 total
includes taxes & fees
May 13 - May 14
Baymont by Wyndham Santee
Red Roof Inn St George, SC
2.5 star property
7.8 out of 10, Good, (486)
"Nice clean facility… staff not very friendly.. coffee in lobby is awful.. but.. great stay for the price"
The price is $71
$79 total
includes taxes & fees
May 5 - May 6
Red Roof Inn St George, SC
Two Palms Lakehouse in Santee Just minutes from I95
7.6 out of 10, Good, (8)
"Great place for a couple days. We took advantage of the lake. Fishing was great for the grandchildren. I highly recommend this place if you enjoy being by the lake. Thank you."
Two Palms Lakehouse in Santee Just minutes from I95
Days Inn by Wyndham St George
2.5 star property
7.2 out of 10, Good, (1002)
"Everything was great except they no longer have waffles at breakfast."
The price is $57
$63 total
includes taxes & fees
May 19 - May 20
Days Inn by Wyndham St George
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Stay near popular Santee attractions

Santee Travel Info

Number of reviews
5,347
Accommodation
206 hotels
Highest price
$169
Lowest price
$57
Reasons to visit
Santee State Park, Santee Cooper Country Club and Santee National Golf Club
Hotels with golf
8
Hotels with family-friendly amenities
3

Frequently asked questions

Where is the best place for a stay in Santee?

Fairfield Inn & Suites by Marriott Santee is a favorite property for Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on traveler reviews include Hampton Inn Santee-I-95 and Tru By Hilton Santee. See all available top hotels, or vacation rentals in Santee.

What are some of the best vacation rentals in Santee?

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable: Visitors like this Santee vacation home rental. It is located on the beach and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 5 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You can relax into your vacation with a garden and a selection of games. See all vacation rentals in Santee.

If I need to cancel my hotel reservation in Santee, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of check in. If you have a reservation that's non-refundable, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Santee.

Where can I learn more about changing or cancelling my trip to Santee?

For more information about updating your trip to Santee or cancelling it, click here.

What's the best budget-friendly hotel in Santee?

Based on reviews, Baymont by Wyndham Santee is a popular hotel for our travelers who want a more economical choice, and features free breakfast and free WiFi. View all budget hotels in Santee.

What's the best hotel for a family vacation in Santee?

Comfort Inn & Suites Santee is a hotel with free parking and free buffet breakfast, and it's a top choice on Expedia for families. Fairfield Inn & Suites by Marriott Santee is another choice for your family trip. Find more child-friendly accommodations in Santee.

What is the top LGBTQ-friendly accommodation in Santee?

Fairfield Inn & Suites by Marriott Santee is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn Santee-I-95 and Holiday Inn Santee, an IHG Hotel are other good options for your stay. See all available hotels listed as LGBTQ-friendly in Santee.

What's the best pet-friendly accommodation in Santee?

Baymont by Wyndham Santee is a top hotel for people traveling with their pets, and offers concierge services and free WiFi for its human guests. Other good choices for you and your pet's trip include Quality Inn & Suites and Tru By Hilton Santee. See more pet-friendly hotel accommodations in Santee.

Where is the best place to stay near Santee State Park?

Baymont by Wyndham Santee is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 3 mi (4.8 km) from Santee State Park. Other good choices within 5 miles include Best Western Plus Santee Inn and Holiday Inn Santee, an IHG Hotel.

What about the best place to stay close to Santee Outlets?

One of the top choices for your stay is Baymont by Wyndham Santee, located a short 0.4 mi (0.6 km) from Santee Outlets, and this hotel offers free breakfast and free parking. Best Western Plus Santee Inn and Fairfield Inn & Suites by Marriott Santee are two other good choices in the immediate area.

What's the best golf hotel in Santee?

Holiday Inn Santee, an IHG Hotel is a top hotel that has an adjacent golf course and features free WiFi. Another good choice is Super 8 by Wyndham Santee if you'd like to be close to a golf course while in town. Visit Santee Cooper Country Club or Santee National Golf Club to perfect your golf swing. See more golf hotels in Santee.

What are some accommodations with pools in Santee?

Comfort Inn & Suites Santee is a top hotel with a seasonal outdoor pool, free buffet breakfast, and free WiFi. A couple of other options that offer an onsite pool include Fairfield Inn & Suites by Marriott Santee and Hampton Inn Santee-I-95. View all hotels with pools in Santee.

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