Find all hotels by Independent in Santee, SC from $70
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Compare rooms and suites by Independent in Santee with rates, reviews, and availability. Most hotels are fully refundable.
Peach Tree Inn
Bells Marina & Resort
Cozy Cottage Just a Block From a Boat Landing and a Beautiful Pristine Lake
Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy
Beautiful Lake Marion Views!! Pet Friendly! Newly renovated and updated!!
Idyllic Waterfront Escape w/ Private Boat Dock!
Come Relax in the Country
The Alamo on Lake Marion
Beautiful lake home to make your family vacation extra special!
Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS
Independent Santee Hotel Guide
Some globe-trotters choose hotels based on location, but others book by name. And thanks to Expedia you don’t have to pick. It is why we offer such an expansive range of Independent hotels in Santee, South Carolina. Known for well-appointed rooms and friendly, personalized service, each of the top Independent Santee hotels guarantees an unparalleled level of comfort and quality.
You’ll find best-in-class amenities like clean rooms and quiet atmospheres, and some Santee Independent locations may even offer extra little benefits and discounts for frequent travelers.
Recent reviews of Santee hotelsExpedia verified reviews
Santee Hotels by Brand
Hotels near popular Santee Attractions
- Hotels near Santee State Park
- Hotels near Santee Cooper Country Club
- Hotels near Santee Outlets
- Hotels near Santee National Golf Club
- Hotels near Congaree National Park
- Hotels near Lake Marion
- Hotels near South Carolina State University
- Hotels near Santee National Wildlife Refuge
- Hotels near Wyboo Golf Club
- Hotels near Edisto Memorial Gardens
More Hotel Options in Santee
- Beach Hotels (1)
- Business Hotels (11)
- Cheap Hotels (7)
- Family Hotels (10)
- Fishing Resorts & Hotels (2)
- Golf Hotels (5)
- Hotel with a Concierge (1)
- Hotels & Resorts for Couples (3)
- Hotels on the Lake (4)
- Hotels with Air Conditioning (10)
- Hotels with Bars (6)
- Hotels with Connecting Rooms (5)
- Hotels with Free Breakfast (10)
- Hotels with Free Parking (11)
- Hotels with Free Wifi (11)
- Hotels with Hot Tubs (3)
- Hotels with Laundry Facilities (6)
- Hotels with Restaurants (11)
- Hotels with Room Service (2)
- Hotels with Suites (1)
- Hotels with a Gym (6)
- Hotels with a Pool (10)
- Hotels with an Indoor Pool (1)
- Hotels with an Outdoor Pool (10)
- Hotels with smoking rooms (1)
- Luxury Hotels (5)
- Non-Smoking Hotels (1)
- Pet-friendly Hotels (10)
- Resorts & Hotels with Spas (2)
More Accommodation Types in Santee
- Condo Rentals (16,454)
- Vacation Homes (14,528)
- Apartments (3,942)
- Villas (3,285)
- Resorts (1,024)
- Cottages (1,005)
- Aparthotels (195)
- Cabin Rentals (181)
- Motels (158)
- B&B (84)
- Guest Houses (68)
- Farmstay (39)
- RV Parks (35)
- Lodges (14)
- Condo Resorts (13)
- Chalets (7)
- Houseboats (7)
- Inns (4)
- Castles (3)
- Country Houses (1)
- Hostels (1)
- Residences (1)
Explore more hotels
- Super 8 by Wyndham Santee
- Two Palms Lakehouse in Santee Just minutes from I95
- Rodeway Inn Santee I-95
- Executive 2 BR/2 BA Lakefront Corner Suite Condo
- Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available
- Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
- Wyndham Vacation Resorts Lake Marion
- SureStay Hotel by Best Western Manning
- Days Inn by Wyndham St George
- Country Inn & Suites by Radisson, Orangeburg, SC
- Tru by Hilton Orangeburg
- Fairfield Inn by Marriott Orangeburg
- Travelodge by Wyndham Orangeburg
- SpringHill Suites by Marriott Orangeburg
- Holiday Inn Express & Suites Orangeburg
- Hampton Inn Manning
- Red Roof Inn St George, SC
- Baymont by Wyndham Manning
- Hampton Inn & Suites Orangeburg
- Baymont by Wyndham Orangeburg North