Find 5 Star Hotels in Texas Medical Center, TX

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Compare Texas Medical Center 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Outdoor pool, cabanas (surcharge), pool umbrellas
The Post Oak Hotel at Uptown Houston
5.0 star property
9.6 out of 10, Exceptional, (610)
"Awesome Hotel!!"
The price is $560
$655 total
includes taxes & fees
Jun 9 - Jun 10
The Post Oak Hotel at Uptown Houston
Outdoor pool, cabanas (surcharge), pool umbrellas
Four Seasons Hotel Houston
5.0 star property
9.2 out of 10, Wonderful, (1024)
"Awesome and Clean "
The price is $480
$565 total
includes taxes & fees
May 28 - May 29
Four Seasons Hotel Houston
Exterior
JW Marriott Houston Downtown
5.0 star property
9.2 out of 10, Wonderful, (1000)
"Excellent location particularly for Astros fans in town!"
The price is $254
$311 total
includes taxes & fees
May 31 - Jun 1
JW Marriott Houston Downtown
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Outdoor pool, free cabanas, pool umbrellas
Hotel Granduca Houston
5.0 star property
9.2 out of 10, Wonderful, (979)
"Great property that could benefit from a few updates"
The price is $305
$357 total
includes taxes & fees
May 26 - May 27
Hotel Granduca Houston
Lounge
The St. Regis Houston
5.0 star property
9.2 out of 10, Wonderful, (369)
"Older hotel. Not up to St Regis standards or prices."
The price is $449
$536 total
includes taxes & fees
Jun 7 - Jun 8
The St. Regis Houston
Front of property
La Colombe d'Or Hotel
5.0 star property
9.2 out of 10, Wonderful, (67)
"Amazing! The staff was above and beyond, the rooms were superb, 10/10!"
The price is $458
$536 total
includes taxes & fees
May 27 - May 28
La Colombe d'Or Hotel
Luxury Villa | Living area | Printers
TUSCAN VILLA
5.0 star property
The price is $2,364
$3,669 total
includes taxes & fees
May 26 - May 27
TUSCAN VILLA

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Texas Medical Center?
You’ll find a range of pricing options for 5-star hotels in Texas Medical Center on Expedia. How much you’ll pay will depend on your vacation dates, length of stay and other factors. Compare available properties for your preferred dates and make use of our pricing and other filters to score the perfect luxury stay.

  • Search for the lowest price per night

What makes a hotel 5 stars in Texas Medical Center?
From gourmet restaurants and 24/7 fitness centers to swimming pools and dreamy bedding, the 5-star experience in Texas Medical Center is all about comfort and luxury. But it takes more than just top-notch amenities to receive a 5-star rating. Accommodations also have to deliver superior services like in-room massage treatments, on-site laundry and 24-hour concierge services.
Are there any 5-star all-inclusive resorts in Texas Medical Center?
Our filter tool is the best way to search for exactly what you want. Select “5-star” and “All inclusive” to see the most luxurious resorts in Texas Medical Center where your meals, accommodations, activities and entertainment are included in the upfront price. At these stays, your vacation is pure extravagance from the moment you check in.
Are there any 5-star vacation rentals in Texas Medical Center?
There are no 5-star vacation rentals in Texas Medical Center on our site, but there are a few other top-rated options worth checking out. Scan through our vacation rentals in Texas Medical Center to discover the perfect place for your getaway.