$282 Cheap Flights from Santa Cruz (VVI) to Uyuni (UYU)

View $282 flight on Fri, May 30, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Santa Cruz to Uyuni (VVI-UYU)

Prices were available within the past 7 days and start at $282 for one-way flights and $563 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Boliviana De Aviacion
Fri, May 30 - Mon, Jun 2
VVI
Santa Cruz
UYU
Uyuni
$563 Roundtrip, just found
$563
Roundtrip
just found
Select Boliviana De Aviacion flight, departing Fri, May 30 from Santa Cruz to Uyuni, returning Mon, Jun 2, priced at $563 just found
Boliviana De Aviacion
Mon, May 5 - Wed, May 7
VVI
Santa Cruz
UYU
Uyuni
$628 Roundtrip, found 7 hours ago
$628
Roundtrip
found 7 hours ago
Select Boliviana De Aviacion flight, departing Mon, May 5 from Santa Cruz to Uyuni, returning Wed, May 7, priced at $628 found 7 hours ago
Flights from Santa Cruz (VVI) to Uyuni (UYU)
Origin airport
Viru Viru Intl.
Destination airport
Uyuni
Airlines serving
Boliviana De Aviacion
Roundtrip price
$563
Distance
309 mi

Santa Cruz to Uyuni Flights

The cheapest times to fly from Santa Cruz to Uyuni

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santa Cruz to Uyuni are during the month of May. You can find some of the cheapest flights from Santa Cruz to Uyuni with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Santa Cruz to Uyuni

Sunday is one of the best days to book for cheap flights from Santa Cruz to Uyuni: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Santa Cruz to Uyuni

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santa Cruz to Uyuni in 2025. You can also book with separate airlines for your outbound and return journeys, from $282 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santa Cruz to Uyuni flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santa Cruz to Uyuni airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Viru Viru Intl. Airport (VVI) to Uyuni Airport (UYU) cost?
Discover the latest flight deals from VVI to UYU by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from VVI to UYU?
The cheapest flights from VVI to UYU are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from VVI to UYU?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from VVI to UYU. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Viru Viru Intl. Airport (VVI) to Uyuni Airport (UYU)?
Nonstop flights from Viru Viru Intl. Airport (VVI) to Uyuni Airport (UYU) aren’t available daily, so you’ll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel dates and choose either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from VVI to UYU?
You’ll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Viru Viru Intl. Airport (VVI) to Uyuni Airport (UYU)?
Choose a flight from Viru Viru Intl. Airport (VVI) to Uyuni Airport (UYU) that leaves before 3 PM to reduce the likelihood of delays. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Viru Viru Intl. Airport (VVI) to Uyuni Airport (UYU) last-minute?
Booking your ticket from VVI to UYU right before your trip is usually more expensive. However, if there’s some wiggle room with your schedule, you could snag a cheap last-minute fare.
Is it cheaper to book a VVI to UYU flight and hotel package?
You’ll generally save money by booking a VVI to UYU flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it’s easy to manage everything in one place. After selecting your ideal flights and accommodations, you can add extras such as activities, tours and car rentals.
Can I cancel or change the date of my flight from Viru Viru Intl. Airport (VVI) to Uyuni Airport (UYU)?
You can usually reschedule or cancel your VVI to UYU flight. However, for bookings made more than 24 hours ago, additional fees may apply. Refer to your airline’s policies in your itinerary to see what changes are possible and whether any costs are involved. You’ll also find more details on our Customer Service portal.

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*Available to One Key members.