$243 Cheap Flights from Santa Cruz (VVI) to Panama City (PTY)

View $243 flight on Wed, Oct 8, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Santa Cruz to Panama City (VVI-PTY)

Prices were available within the past 7 days and start at $243 for one-way flights and $441 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Wed, Oct 8 - Wed, Oct 22
VVI
Santa Cruz
PTY
Panama City
$441 Roundtrip, found 5 hours ago
$441
Roundtrip
found 5 hours ago
Select avianca flight, departing Wed, Oct 8 from Santa Cruz to Panama City, returning Wed, Oct 22, priced at $441 found 5 hours ago
avianca
Wed, Oct 8 - Wed, Oct 22
VVI
Santa Cruz
PTY
Panama City
$472 Roundtrip, found 5 hours ago
$472
Roundtrip
found 5 hours ago
Select avianca flight, departing Wed, Oct 8 from Santa Cruz to Panama City, returning Wed, Oct 22, priced at $472 found 5 hours ago
avianca
Fri, May 16 - Wed, May 21
VVI
Santa Cruz
PTY
Panama City
$503 Roundtrip, found 3 days ago
$503
Roundtrip
found 3 days ago
Select avianca flight, departing Fri, May 16 from Santa Cruz to Panama City, returning Wed, May 21, priced at $503 found 3 days ago
avianca
Wed, Oct 8 - Wed, Oct 22
VVI
Santa Cruz
PTY
Panama City
$602 Roundtrip, found 5 hours ago
$602
Roundtrip
found 5 hours ago
Select avianca flight, departing Wed, Oct 8 from Santa Cruz to Panama City, returning Wed, Oct 22, priced at $602 found 5 hours ago
avianca
Wed, Oct 8 - Wed, Oct 22
VVI
Santa Cruz
PTY
Panama City
$633 Roundtrip, found 5 hours ago
$633
Roundtrip
found 5 hours ago
Select avianca flight, departing Wed, Oct 8 from Santa Cruz to Panama City, returning Wed, Oct 22, priced at $633 found 5 hours ago
avianca
Mon, Aug 4 - Fri, Aug 8
VVI
Santa Cruz
PTY
Panama City
$635 Roundtrip, found 13 hours ago
$635
Roundtrip
found 13 hours ago
Select avianca flight, departing Mon, Aug 4 from Santa Cruz to Panama City, returning Fri, Aug 8, priced at $635 found 13 hours ago
Copa
Fri, Jun 20 - Tue, Jul 1
VVI
Santa Cruz
PTY
Panama City
$648 Roundtrip, found 1 day ago
$648
Roundtrip
found 1 day ago
Select Copa flight, departing Fri, Jun 20 from Santa Cruz to Panama City, returning Tue, Jul 1, priced at $648 found 1 day ago
Copa
Tue, May 20 - Mon, Jun 2
VVI
Santa Cruz
PTY
Panama City
$659 Roundtrip, found 5 days ago
$659
Roundtrip
found 5 days ago
Select Copa flight, departing Tue, May 20 from Santa Cruz to Panama City, returning Mon, Jun 2, priced at $659 found 5 days ago
avianca
Fri, May 16 - Wed, May 21
VVI
Santa Cruz
PTY
Panama City
$664 Roundtrip, found 3 days ago
$664
Roundtrip
found 3 days ago
Select avianca flight, departing Fri, May 16 from Santa Cruz to Panama City, returning Wed, May 21, priced at $664 found 3 days ago
avianca
Wed, Apr 30 - Fri, May 2
VVI
Santa Cruz
PTY
Panama City
$666 Roundtrip, found 11 hours ago
$666
Roundtrip
found 11 hours ago
Select avianca flight, departing Wed, Apr 30 from Santa Cruz to Panama City, returning Fri, May 2, priced at $666 found 11 hours ago
Flights from Santa Cruz (VVI) to Panama City (PTY)
Origin airport
Viru Viru Intl.
Destination airport
Tocumen Intl.
Airlines serving
Copa, avianca
Roundtrip price
$441
Distance
2153 mi

Santa Cruz to Panama City Flights

The cheapest times to fly from Santa Cruz to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santa Cruz to Panama City are during the month of October. You can find some of the cheapest flights from Santa Cruz to Panama City with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Santa Cruz to Panama City

Sunday is one of the best days to book for cheap flights from Santa Cruz to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Santa Cruz to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santa Cruz to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $243 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santa Cruz to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santa Cruz to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY) cost?
Cheap round-trip fares from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY) start from $774. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving VVI on May 11 2025 and touching down at PTY. The price was last updated on April 23 2025 and has not changed since.
What is the cheapest month to fly from VVI to PTY?
The cheapest flights from VVI to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY)?
When departing from Viru Viru Intl. Airport (VVI), you can take a nonstop flight to Tocumen Intl. Airport (PTY) with Copa Airlines.
What is the cheapest airline that flies from VVI to PTY?
With prices as low as $815 for a one-way flight from VVI to PTY, Copa is currently the cheapest carrier flying this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from VVI on June 14 2025. Prices were last updated on April 23 2025 and have not changed since.
How many flights per day from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY)?
On average, just 1 nonstop flight departs daily from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY). Need other options? Use our filter tool to find flights with layovers and add an extra destination to your journey.
What are the most popular departure times for flights from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY)?
More people fly between VVI and PTY at 12 AM than at any other time. Rather skip the crowds? Try choosing a quieter departure window and it’s possible you’ll save on your ticket as well.
What day of the week has the most flights from VVI to PTY?
Friday has the most flights from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY). Consider taking off on this day and you’ll have the best chance of finding a departure that fits your plans.
What is the earliest flight from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY)?
Take the earliest flight at around 12:52AM UTC-4, leaving from Viru Viru Intl. Airport (VVI). You’ll be in the air for around 4h 49m, reaching Tocumen Intl. Airport (PTY) at approximately 4:41AM UTC-5.
How long does it take to fly from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY)?
Typically, it takes 4 hours and 50 minutes to fly the 2,200 mi from VVI to PTY.
What airline has the least delays from VVI to PTY?
Copa Airlines has the best performance for on-time direct flights from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY), with an on-time rating of 98%. Use the Expedia App to see your journey status before you jet off and receive notifications about any changes.
What is the best time to fly from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY) route, aim to fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Panama City from Viru Viru Intl. Airport (VVI)?
If you’re flying on a direct flight from Viru Viru Intl. Airport (VVI) to Panama City, Tocumen Intl. Airport (PTY) is the only airport you can touch down at.
Is it cheaper to buy a plane ticket from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY) last-minute?
Last-minute fares from VVI to PTY are generally more expensive. For the best rates, start looking for flights as soon as possible. That being said, if you can play around with your travel dates, you may land a cheap ticket just before your departure.
Is it cheaper to book a VVI to PTY flight and hotel package?
You’ll generally save money by booking a VVI to PTY flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it’s simple to manage everything in one place. After choosing your ideal flights and accommodations, consider adding extras including car rentals, activities and tours.
Can I cancel or change the date of my flight from Viru Viru Intl. Airport (VVI) to Tocumen Intl. Airport (PTY)?
You can usually reschedule or cancel your VVI to PTY flight. However, if it’s been more than 24 hours since booking, additional fees may apply. Refer to your airline’s policies in your itinerary to see what changes are possible and if any costs are involved. You’ll also find further details on our Customer Service portal.

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*Available to One Key members.