$114 Cheap Flights from Knoxville (TYS) to San Francisco (SFO)

View $114 flight on Thu, May 29, 2025Opens in a new window

Popular airlines from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO)

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Find available prices by choosing your travel dates.

Cheap Flights from Knoxville to San Francisco (TYS-SFO)

Prices were available within the past 7 days and start at $114 for one-way flights and $218 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Thu, May 29 - Sat, May 31
TYS
Knoxville
SFO
San Francisco
$218 Roundtrip, found 12 hours ago
$218
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Thu, May 29 from Knoxville to San Francisco, returning Sat, May 31, priced at $218 found 12 hours ago
Frontier Airlines
Thu, May 29 - Thu, Jun 5
TYS
Knoxville
SFO
San Francisco
$228 Roundtrip, found 11 hours ago
$228
Roundtrip
found 11 hours ago
Select Frontier Airlines flight, departing Thu, May 29 from Knoxville to San Francisco, returning Thu, Jun 5, priced at $228 found 11 hours ago
Frontier Airlines
Thu, May 22 - Thu, May 29
TYS
Knoxville
SFO
San Francisco
$248 Roundtrip, found 12 hours ago
$248
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Thu, May 22 from Knoxville to San Francisco, returning Thu, May 29, priced at $248 found 12 hours ago
American Airlines
Wed, Jul 2 - Sat, Jul 5
TYS
Knoxville
SFO
San Francisco
$249 Roundtrip, found 2 days ago
$249
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jul 2 from Knoxville to San Francisco, returning Sat, Jul 5, priced at $249 found 2 days ago
United
Wed, Jul 2 - Sat, Jul 5
TYS
Knoxville
SFO
San Francisco
$251 Roundtrip, found 2 days ago
$251
Roundtrip
found 2 days ago
Select United flight, departing Wed, Jul 2 from Knoxville to San Francisco, returning Sat, Jul 5, priced at $251 found 2 days ago
Delta
Fri, May 30 - Sun, Jun 1
TYS
Knoxville
SFO
San Francisco
$263 Roundtrip, found 12 hours ago
$263
Roundtrip
found 12 hours ago
Select Delta flight, departing Fri, May 30 from Knoxville to San Francisco, returning Sun, Jun 1, priced at $263 found 12 hours ago
United
Fri, May 30 - Sun, Jun 1
TYS
Knoxville
SFO
San Francisco
$264 Roundtrip, found 12 hours ago
$264
Roundtrip
found 12 hours ago
Select United flight, departing Fri, May 30 from Knoxville to San Francisco, returning Sun, Jun 1, priced at $264 found 12 hours ago
United
Wed, Jul 2 - Sat, Jul 5
TYS
Knoxville
SFO
San Francisco
$265 Roundtrip, found 2 days ago
$265
Roundtrip
found 2 days ago
Select United flight, departing Wed, Jul 2 from Knoxville to San Francisco, returning Sat, Jul 5, priced at $265 found 2 days ago
United
Fri, May 30 - Sun, Jun 1
TYS
Knoxville
SFO
San Francisco
$269 Roundtrip, found 12 hours ago
$269
Roundtrip
found 12 hours ago
Select United flight, departing Fri, May 30 from Knoxville to San Francisco, returning Sun, Jun 1, priced at $269 found 12 hours ago
Alaska Airlines
Thu, May 8 - Sun, May 11
TYS
Knoxville
SFO
San Francisco
$469 Roundtrip, found 4 hours ago
$469
Roundtrip
found 4 hours ago
Select Alaska Airlines flight, departing Thu, May 8 from Knoxville to San Francisco, returning Sun, May 11, priced at $469 found 4 hours ago
Flights from Knoxville (TYS) to San Francisco (SFO)
Origin airport
McGhee Tyson
Destination airport
San Francisco Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, Frontier Airlines, United
Roundtrip price
$218
Distance
2115 mi

Knoxville to San Francisco Flights

The cheapest times to fly from Knoxville to San Francisco

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to San Francisco are during the month of May. You can find some of the cheapest flights from Knoxville to San Francisco with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Knoxville to San Francisco

Sunday is one of the best days to book for cheap flights from Knoxville to San Francisco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Knoxville to San Francisco

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to San Francisco in 2025. You can also book with separate airlines for your outbound and return journeys, from $114 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to San Francisco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to San Francisco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO) cost?
Discover the latest flight deals from TYS to SFO by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from TYS to SFO?
The cheapest flights from TYS to SFO are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from TYS to SFO?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from TYS to SFO. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO)?
Direct flights from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO) aren’t available daily, so you’ll have to take a flight with a layover. Explore your options with our filter tool. Enter your travel details and click on either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from TYS to SFO?
You’ll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO)?
To touch down at San Francisco Intl. Airport (SFO) without delays, pick a flight that leaves from McGhee Tyson Airport (TYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO) last-minute?
Last-minute fares from TYS to SFO are typically more expensive. To secure the lowest rates, start looking for flights as soon as possible. That being said, if your travel plans are flexible, it’s possible to find a cheap ticket right before your trip.
Is it cheaper to book a TYS to SFO flight and hotel package?
Booking a TYS to SFO flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Choose from our impressive range of hotels and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to San Francisco Intl. Airport (SFO)?
If you reserved your TYS to SFO flight within the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for further details.

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*Available to One Key members.