$100 Cheap Flights from Knoxville (TYS) to Fort Myers (RSW)

View $100 flight on Sun, May 25, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Knoxville to Fort Myers (TYS-RSW)

Prices were available within the past 7 days and start at $100 for one-way flights and $224 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, Jul 4 - Mon, Jul 7
TYS
Knoxville
RSW
Fort Myers
$224 Roundtrip, found 16 hours ago
$224
Roundtrip
found 16 hours ago
Select Delta flight, departing Fri, Jul 4 from Knoxville to Fort Myers, returning Mon, Jul 7, priced at $224 found 16 hours ago
American Airlines
Sat, May 24 - Wed, May 28
TYS
Knoxville
RSW
Fort Myers
$225 Roundtrip, found 3 hours ago
$225
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, May 24 from Knoxville to Fort Myers, returning Wed, May 28, priced at $225 found 3 hours ago
American Airlines
Sat, May 24 - Wed, May 28
TYS
Knoxville
RSW
Fort Myers
$226 Roundtrip, found 3 hours ago
$226
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, May 24 from Knoxville to Fort Myers, returning Wed, May 28, priced at $226 found 3 hours ago
United
Wed, May 21 - Sat, May 24
TYS
Knoxville
RSW
Fort Myers
$228 Roundtrip, found 21 hours ago
$228
Roundtrip
found 21 hours ago
Select United flight, departing Wed, May 21 from Knoxville to Fort Myers, returning Sat, May 24, priced at $228 found 21 hours ago
Delta
Thu, May 29 - Fri, May 30
TYS
Knoxville
RSW
Fort Myers
$232 Roundtrip, found 2 days ago
$232
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, May 29 from Knoxville to Fort Myers, returning Fri, May 30, priced at $232 found 2 days ago
United
Tue, May 20 - Fri, May 30
TYS
Knoxville
RSW
Fort Myers
$233 Roundtrip, found 1 day ago
$233
Roundtrip
found 1 day ago
Select United flight, departing Tue, May 20 from Knoxville to Fort Myers, returning Fri, May 30, priced at $233 found 1 day ago
United
Thu, Aug 14 - Thu, Aug 21
TYS
Knoxville
RSW
Fort Myers
$249 Roundtrip, found 17 hours ago
$249
Roundtrip
found 17 hours ago
Select United flight, departing Thu, Aug 14 from Knoxville to Fort Myers, returning Thu, Aug 21, priced at $249 found 17 hours ago
Delta
Tue, Jul 15 - Wed, Jul 16
TYS
Knoxville
RSW
Fort Myers
$251 Roundtrip, found 12 hours ago
$251
Roundtrip
found 12 hours ago
Select Delta flight, departing Tue, Jul 15 from Knoxville to Fort Myers, returning Wed, Jul 16, priced at $251 found 12 hours ago
American Airlines
Sat, May 10 - Sat, May 17
TYS
Knoxville
RSW
Fort Myers
$254 Roundtrip, found 6 hours ago
$254
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Sat, May 10 from Knoxville to Fort Myers, returning Sat, May 17, priced at $254 found 6 hours ago
United
Fri, Jun 6 - Wed, Jun 11
TYS
Knoxville
RSW
Fort Myers
$254 Roundtrip, found 10 hours ago
$254
Roundtrip
found 10 hours ago
Select United flight, departing Fri, Jun 6 from Knoxville to Fort Myers, returning Wed, Jun 11, priced at $254 found 10 hours ago
Flights from Knoxville (TYS) to Fort Myers (RSW)
Origin airport
McGhee Tyson
Destination airport
Southwest Florida Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$198
Distance
654 mi

Knoxville to Fort Myers Flights

The cheapest times to fly from Knoxville to Fort Myers

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Fort Myers are during the month of July. You can find some of the cheapest flights from Knoxville to Fort Myers with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Knoxville to Fort Myers

Sunday is one of the best days to book for cheap flights from Knoxville to Fort Myers: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Knoxville to Fort Myers

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Fort Myers in 2025. You can also book with separate airlines for your outbound and return journeys, from $100 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Fort Myers flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Fort Myers airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Southwest Florida Intl. Airport (RSW) cost?
Discover the latest flight deals from TYS to RSW by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from TYS to RSW?
The cheapest flights from TYS to RSW are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from TYS to RSW?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from TYS to RSW. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from McGhee Tyson Airport (TYS) to Southwest Florida Intl. Airport (RSW)?
There are no daily nonstop flights available from McGhee Tyson Airport (TYS) to Southwest Florida Intl. Airport (RSW). But you can book flights with layovers. Filter your search results on Expedia to include one or more stops, and you’ll be cruising above the clouds before you know it.
What day of the week has the most flights from TYS to RSW?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change depending on a number of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Southwest Florida Intl. Airport (RSW)?
Opt for a flight from McGhee Tyson Airport (TYS) to Southwest Florida Intl. Airport (RSW) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Fort Myers from McGhee Tyson Airport (TYS)?
If you’re traveling on a direct flight from McGhee Tyson Airport (TYS) to Fort Myers, Charlotte County Airport (PGD) is the only airport you can touch down at.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Southwest Florida Intl. Airport (RSW) last-minute?
Last-minute fares from TYS to RSW are typically more expensive. To lock in the best prices, start searching for flights as early as possible. That being said, if you can play around with your travel dates, you may land a cheap ticket right before you leave.
Is it cheaper to book a TYS to RSW flight and hotel package?
Compared with arranging flights and hotels separately, booking a TYS to RSW flight and hotel package with Expedia could lead to significant savings. Better yet, managing everything in one place takes the hassle out of travel planning. Simply pick your flights and choose from our extensive range of hotels, then tailor your trip with other add-ons like activities, tours and car rentals.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Southwest Florida Intl. Airport (RSW)?
In most instances, you can reschedule or cancel your TYS to RSW flight. However, additional fees may apply, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline’s fees and rules on flight changes, or if you need more details, head to our Customer Service portal.

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*Available to One Key members.