$114 Cheap Flights from Knoxville (TYS) to Chicago (ORD)

View $114 flight on Sun, May 25, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Knoxville to Chicago (TYS-ORD)

Prices were available within the past 7 days and start at $114 for one-way flights and $189 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Fri, Aug 1 - Sun, Aug 3
TYS
Knoxville
ORD
Chicago
$189 Roundtrip, found 1 hour ago
$189
Roundtrip
found 1 hour ago
Select United flight, departing Fri, Aug 1 from Knoxville to Chicago, returning Sun, Aug 3, priced at $189 found 1 hour ago
United
Fri, May 16 - Tue, May 20
TYS
Knoxville
ORD
Chicago
$193 Roundtrip, found 1 day ago
$193
Roundtrip
found 1 day ago
Select United flight, departing Fri, May 16 from Knoxville to Chicago, returning Tue, May 20, priced at $193 found 1 day ago
United
Fri, May 16 - Mon, May 19
TYS
Knoxville
ORD
Chicago
$194 Roundtrip, found 1 hour ago
$194
Roundtrip
found 1 hour ago
Select United flight, departing Fri, May 16 from Knoxville to Chicago, returning Mon, May 19, priced at $194 found 1 hour ago
United
Sat, Sep 27 - Tue, Sep 30
TYS
Knoxville
ORD
Chicago
$194 Roundtrip, found 3 hours ago
$194
Roundtrip
found 3 hours ago
Select United flight, departing Sat, Sep 27 from Knoxville to Chicago, returning Tue, Sep 30, priced at $194 found 3 hours ago
United
Wed, May 7 - Wed, May 21
TYS
Knoxville
ORD
Chicago
$199 Roundtrip, found 1 day ago
$199
Roundtrip
found 1 day ago
Select United flight, departing Wed, May 7 from Knoxville to Chicago, returning Wed, May 21, priced at $199 found 1 day ago
United
Tue, Jul 1 - Fri, Jul 11
TYS
Knoxville
ORD
Chicago
$199 Roundtrip, found 2 hours ago
$199
Roundtrip
found 2 hours ago
Select United flight, departing Tue, Jul 1 from Knoxville to Chicago, returning Fri, Jul 11, priced at $199 found 2 hours ago
Delta
Wed, May 14 - Fri, Jul 4
TYS
Knoxville
ORD
Chicago
$204 Roundtrip, found 2 days ago
$204
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, May 14 from Knoxville to Chicago, returning Fri, Jul 4, priced at $204 found 2 days ago
United
Tue, Jul 1 - Fri, Jul 11
TYS
Knoxville
ORD
Chicago
$204 Roundtrip, found 2 hours ago
$204
Roundtrip
found 2 hours ago
Select United flight, departing Tue, Jul 1 from Knoxville to Chicago, returning Fri, Jul 11, priced at $204 found 2 hours ago
American Airlines
Wed, Oct 8 - Sun, Oct 12
TYS
Knoxville
ORD
Chicago
$219 Roundtrip, just found
$219
Roundtrip
just found
Select American Airlines flight, departing Wed, Oct 8 from Knoxville to Chicago, returning Sun, Oct 12, priced at $219 just found
Frontier Airlines
Sun, May 25 - Thu, Jun 5
TYS
Knoxville
ORD
Chicago
$220 Roundtrip, found 4 days ago
$220
Roundtrip
found 4 days ago
Select Frontier Airlines flight, departing Sun, May 25 from Knoxville to Chicago, returning Thu, Jun 5, priced at $220 found 4 days ago
Flights from Knoxville (TYS) to Chicago (ORD)
Origin airport
McGhee Tyson
Destination airport
O'Hare Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Roundtrip price
$189
Distance
475 mi

Knoxville to Chicago Flights

The cheapest times to fly from Knoxville to Chicago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Chicago are during the month of August. You can find some of the cheapest flights from Knoxville to Chicago with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Knoxville to Chicago

Sunday is one of the best days to book for cheap flights from Knoxville to Chicago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Knoxville to Chicago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Chicago in 2025. You can also book with separate airlines for your outbound and return journeys, from $114 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Chicago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Chicago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD) cost?
Book cheap return tickets starting from $184 from McGhee Tyson Airport (TYS) to O’Hare Intl. Airport (ORD). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a United flight leaving TYS on May 16 2025 and touching down at ORD. The price was last updated on April 24 2025 and has not changed since.
What is the cheapest month to fly from TYS to ORD?
The cheapest flights from TYS to ORD are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
Jump on a nonstop flight with United Airlines and travel straight from McGhee Tyson Airport (TYS) to O’Hare Intl. Airport (ORD).
What is the cheapest airline that flies from TYS to ORD?
With prices starting from $90 for a one-way flight from TYS to ORD, United is currently the cheapest airline for this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from TYS on July 2 2025. Prices were last updated on April 24 2025 and have not changed since.
How many flights per day from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
When taking off from McGhee Tyson Airport (TYS), you’ll have a choice from an average of 5 daily nonstop flights to O’Hare Intl. Airport (ORD).
What are the most popular departure times for flights from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
Flights between TYS and ORD are busiest at 1 PM. If you’re after a more relaxed experience and potentially cheaper tickets, choose a departure outside the usual busy windows.
What day of the week has the most flights from TYS to ORD?
Friday offers the most flights from McGhee Tyson Airport (TYS) to O’Hare Intl. Airport (ORD). Consider taking off on this day and you’ll have a greater chance of finding a departure that fits your itinerary.
What is the earliest flight from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
Hop on the earliest flight at around 6:20AM UTC-5, leaving from McGhee Tyson Airport (TYS). You’ll be traveling for approximately 2h 7m, arriving at O’Hare Intl. Airport (ORD) at approximately 7:27AM UTC-6.
How long does it take to fly from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
It takes roughly 1 hour and 58 minutes to travel the 480 mi from TYS to ORD.
What airline has the least delays from TYS to ORD?
Alaska Airlines has the best performance for on-time direct flights from McGhee Tyson Airport (TYS) to O’Hare Intl. Airport (ORD), with an on-time score of 90%. Use the Expedia App to see your flight status before you leave and get real-time updates about any trip changes.
What is the best time to fly from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
Book a flight from McGhee Tyson Airport (TYS) to O’Hare Intl. Airport (ORD) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Chicago from McGhee Tyson Airport (TYS)?
If you’re flying on a direct flight from McGhee Tyson Airport (TYS) to Chicago, O’Hare Intl. Airport (ORD) is the only airport you can land at.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD) last-minute?
Booking your flight from TYS to ORD shortly before your getaway is usually more expensive. However, if you’re flexible with your schedule, you could score a cheap last-minute fare.
Is it cheaper to book a TYS to ORD flight and hotel package?
You’ll typically save money by booking a TYS to ORD flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it’s easy to manage it all in one place. Once you’ve selected your ideal flights and accommodations, you can add extras like car rentals, tours and activities.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to O'Hare Intl. Airport (ORD)?
If you booked your TYS to ORD flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more details.

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*Available to One Key members.