$144 Cheap Flights from Knoxville (TYS) to Jacksonville (JAX)

View $144 flight on Sun, Aug 31, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Knoxville to Jacksonville (TYS-JAX)

Prices were available within the past 7 days and start at $144 for one-way flights and $221 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, May 14 - Tue, May 20
TYS
Knoxville
JAX
Jacksonville
$221 Roundtrip, found 23 hours ago
$221
Roundtrip
found 23 hours ago
Select Delta flight, departing Wed, May 14 from Knoxville to Jacksonville, returning Tue, May 20, priced at $221 found 23 hours ago
American Airlines
Wed, May 7 - Wed, May 14
TYS
Knoxville
JAX
Jacksonville
$246 Roundtrip, found 12 hours ago
$246
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Wed, May 7 from Knoxville to Jacksonville, returning Wed, May 14, priced at $246 found 12 hours ago
Delta
Tue, May 20 - Wed, Jun 11
TYS
Knoxville
JAX
Jacksonville
$254 Roundtrip, found 14 hours ago
$254
Roundtrip
found 14 hours ago
Select Delta flight, departing Tue, May 20 from Knoxville to Jacksonville, returning Wed, Jun 11, priced at $254 found 14 hours ago
American Airlines
Wed, May 7 - Wed, May 14
TYS
Knoxville
JAX
Jacksonville
$271 Roundtrip, found 12 hours ago
$271
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Wed, May 7 from Knoxville to Jacksonville, returning Wed, May 14, priced at $271 found 12 hours ago
Delta
Tue, May 6 - Tue, May 13
TYS
Knoxville
JAX
Jacksonville
$275 Roundtrip, found 2 days ago
$275
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, May 6 from Knoxville to Jacksonville, returning Tue, May 13, priced at $275 found 2 days ago
Delta
Wed, May 7 - Sat, May 17
TYS
Knoxville
JAX
Jacksonville
$279 Roundtrip, found 13 hours ago
$279
Roundtrip
found 13 hours ago
Select Delta flight, departing Wed, May 7 from Knoxville to Jacksonville, returning Sat, May 17, priced at $279 found 13 hours ago
United
Wed, Jun 4 - Sat, Jun 7
TYS
Knoxville
JAX
Jacksonville
$287 Roundtrip, found 3 days ago
$287
Roundtrip
found 3 days ago
Select United flight, departing Wed, Jun 4 from Knoxville to Jacksonville, returning Sat, Jun 7, priced at $287 found 3 days ago
Delta
Sat, Jun 28 - Wed, Jul 2
TYS
Knoxville
JAX
Jacksonville
$289 Roundtrip, found 2 days ago
$289
Roundtrip
found 2 days ago
Select Delta flight, departing Sat, Jun 28 from Knoxville to Jacksonville, returning Wed, Jul 2, priced at $289 found 2 days ago
Delta
Wed, Jun 11 - Tue, Jun 17
TYS
Knoxville
JAX
Jacksonville
$291 Roundtrip, found 3 hours ago
$291
Roundtrip
found 3 hours ago
Select Delta flight, departing Wed, Jun 11 from Knoxville to Jacksonville, returning Tue, Jun 17, priced at $291 found 3 hours ago
Delta
Tue, May 20 - Mon, Jun 9
TYS
Knoxville
JAX
Jacksonville
$294 Roundtrip, found 14 hours ago
$294
Roundtrip
found 14 hours ago
Select Delta flight, departing Tue, May 20 from Knoxville to Jacksonville, returning Mon, Jun 9, priced at $294 found 14 hours ago
Flights from Knoxville (TYS) to Jacksonville (JAX)
Origin airport
McGhee Tyson
Destination airport
Jacksonville Intl.
Airlines serving
American Airlines, Delta, United
Roundtrip price
$220
Distance
390 mi

Knoxville to Jacksonville Flights

The cheapest times to fly from Knoxville to Jacksonville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Jacksonville are during the month of May. You can find some of the cheapest flights from Knoxville to Jacksonville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Knoxville to Jacksonville

Sunday is one of the best days to book for cheap flights from Knoxville to Jacksonville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Knoxville to Jacksonville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Jacksonville in 2025. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Jacksonville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Jacksonville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX) cost?
Discover the latest flight deals from TYS to JAX by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from TYS to JAX?
The cheapest flights from TYS to JAX are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from TYS to JAX?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from TYS to JAX. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX)?
On average, you can take your pick of 2 nonstop flights departing from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX) every week. If you don’t find one that fits your schedule, consider hopping on a flight with a layover. Filter your search results on Expedia to include one or two stops and opt for the best alternative.
What are the most popular departure times for flights from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX)?
More people fly between TYS and JAX at 8 AM than at any other time. Rather go when it’s quieter? Try choosing a quieter departure window and you could save on your ticket as well.
What day of the week has the most flights from TYS to JAX?
Depart on a Friday if you’re searching for the best selection of flights from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX).
What is the earliest flight from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX)?
McGhee Tyson Airport (TYS)’s first flight to Jacksonville Intl. Airport (JAX) takes off at approximately 8:30AM UTC-5. With a flight time of 1h 34m, you’ll touch down at around 10:04AM UTC-5.
How long does it take to fly from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX)?
The average flight time from TYS to JAX is 1 hour and 34 minutes, covering a total distance of 390 mi.
What airline has the least delays from TYS to JAX?
Delta Air Lines has the best track record for on-time direct flights from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX), with an on-time rating of 100%. Use the Expedia App to view your journey status before you jet off and get real-time updates about any trip changes.
What is the best time to fly from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX)?
Book a flight from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures after this time have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Jacksonville from McGhee Tyson Airport (TYS)?
If you’re traveling on a direct flight from McGhee Tyson Airport (TYS) to Jacksonville, Jacksonville Intl. Airport (JAX) is the only airport you can touch down at.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX) last-minute?
Waiting until just before your trip to book your flight from TYS to JAX often results in higher prices. While you may find some last-minute offers, they’re not always guaranteed. Keep your travel schedule open for the best chance of landing a bargain.
Is it cheaper to book a TYS to JAX flight and hotel package?
Compared with arranging flights and hotels separately, booking a TYS to JAX flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one easy place will take the hassle out of planning your trip. Simply secure your flights and select from our wide range of hotels, then customize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Jacksonville Intl. Airport (JAX)?
If you booked your TYS to JAX flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you’d like more information.

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*Available to One Key members.