$144 Cheap Flights from Knoxville (TYS) to Gainesville (GNV)

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Cheap Flights from Knoxville to Gainesville (TYS-GNV)

Prices were available within the past 7 days and start at $144 for one-way flights and $317 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Delta
Delta
American Airlines
Delta
Delta
American Airlines
Delta
American Airlines
Delta
Flights from Knoxville (TYS) to Gainesville (GNV)
Origin airport
McGhee Tyson
Destination airport
Gainesville Regional
Airlines serving
American Airlines, Delta
Roundtrip price
$316
Distance
434 mi

Knoxville to Gainesville Flights

The cheapest times to fly from Knoxville to Gainesville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Gainesville are during the month of July. You can find some of the cheapest flights from Knoxville to Gainesville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Knoxville to Gainesville

Sunday is one of the best days to book for cheap flights from Knoxville to Gainesville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Knoxville to Gainesville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Gainesville in 2025. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Gainesville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Gainesville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Gainesville Regional Airport last minute?
Booking your journey from McGhee Tyson Airport (TYS) to Gainesville Regional Airport (GNV) at the last minute could save you dollars if you hit the jackpot and find a real bargain. However, tickets usually don’t get cheaper as the date of departure nears. If you hold off, flights could also be booked up or the best seats taken. If you’d rather err on the side of caution, book well in advance of the date you want to leave. Remember that some of the most awesome deals can be found up to 12 months in advance. If your preferred airline hasn’t released its airfares yet, check back regularly as deals are constantly updated on Expedia.
What airports do you fly into for Gainesville from Knoxville?
From Knoxville, you can travel to Gainesville via Gainesville Regional Airport (GNV), Ocala, FL (OCF-Ocala Intl.) and Cecil Airport (VQQ). It’s wise to check which airport is the right option for you before making your decision. If you decide to land at Gainesville Regional Airport (GNV), it’s approximately 4 mi northeast of the center of the city. Use the dollars you save when booking your seat with Expedia to discover the city’s well-known sights, such as University of Florida and Florida Museum of Natural History.
Can I change the date of my flight from Knoxville Airport to Gainesville Regional Airport (GNV)?
Expedia makes it a breeze to make changes to your McGhee Tyson Airport (TYS) to Gainesville Regional Airport (GNV) trip yourself. Access your details via the Expedia Trips portal and choose “change flight.” Browse around for new flights and book the one that better suits your plans. You’ll see an estimate of applicable flight change fees. Alternatively, head to our Customer Service portal to connect with our Virtual Agent and get answers to your questions.

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*Available to One Key members.