$126 Cheap Flights from Knoxville (TYS) to Key West (EYW)

View $126 flight on Tue, May 27, 2025Opens in a new window
Find available prices by choosing your travel dates.

Cheap Flights from Knoxville to Key West (TYS-EYW)

Prices were available within the past 7 days and start at $126 for one-way flights and $199 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, May 28 - Fri, May 30
TYS
Knoxville
EYW
Key West
$199 Roundtrip, found 2 days ago
$199
Roundtrip
found 2 days ago
Select Delta flight, departing Wed, May 28 from Knoxville to Key West, returning Fri, May 30, priced at $199 found 2 days ago
Delta
Tue, Jul 1 - Thu, Jul 10
TYS
Knoxville
EYW
Key West
$224 Roundtrip, found 16 hours ago
$224
Roundtrip
found 16 hours ago
Select Delta flight, departing Tue, Jul 1 from Knoxville to Key West, returning Thu, Jul 10, priced at $224 found 16 hours ago
American Airlines
Tue, May 27 - Thu, May 29
TYS
Knoxville
EYW
Key West
$228 Roundtrip, found 6 days ago
$228
Roundtrip
found 6 days ago
Select American Airlines flight, departing Tue, May 27 from Knoxville to Key West, returning Thu, May 29, priced at $228 found 6 days ago
American Airlines
Mon, Sep 8 - Sat, Sep 13
TYS
Knoxville
EYW
Key West
$249 Roundtrip, found 9 hours ago
$249
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Mon, Sep 8 from Knoxville to Key West, returning Sat, Sep 13, priced at $249 found 9 hours ago
Delta
Tue, Aug 26 - Wed, Aug 27
TYS
Knoxville
EYW
Key West
$251 Roundtrip, found 7 hours ago
$251
Roundtrip
found 7 hours ago
Select Delta flight, departing Tue, Aug 26 from Knoxville to Key West, returning Wed, Aug 27, priced at $251 found 7 hours ago
Delta
Sun, May 11 - Wed, May 21
TYS
Knoxville
EYW
Key West
$254 Roundtrip, found 1 day ago
$254
Roundtrip
found 1 day ago
Select Delta flight, departing Sun, May 11 from Knoxville to Key West, returning Wed, May 21, priced at $254 found 1 day ago
American Airlines
Sat, Sep 13 - Sat, Sep 20
TYS
Knoxville
EYW
Key West
$254 Roundtrip, found 4 days ago
$254
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Sep 13 from Knoxville to Key West, returning Sat, Sep 20, priced at $254 found 4 days ago
Delta
Thu, May 29 - Fri, May 30
TYS
Knoxville
EYW
Key West
$259 Roundtrip, found 2 days ago
$259
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, May 29 from Knoxville to Key West, returning Fri, May 30, priced at $259 found 2 days ago
Delta
Tue, May 27 - Thu, May 29
TYS
Knoxville
EYW
Key West
$263 Roundtrip, found 6 days ago
$263
Roundtrip
found 6 days ago
Select Delta flight, departing Tue, May 27 from Knoxville to Key West, returning Thu, May 29, priced at $263 found 6 days ago
United
Thu, Jul 31 - Mon, Aug 4
TYS
Knoxville
EYW
Key West
$386 Roundtrip, found 7 hours ago
$386
Roundtrip
found 7 hours ago
Select United flight, departing Thu, Jul 31 from Knoxville to Key West, returning Mon, Aug 4, priced at $386 found 7 hours ago

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW) cost?
Discover the latest flight deals from TYS to EYW by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from TYS to EYW?
The cheapest flights from TYS to EYW are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from TYS to EYW?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from TYS to EYW. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?
Nonstop flights from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW) aren’t available daily, so you’ll have to take a flight with a layover. Explore your options with our filter tool. Enter your dates and select either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from TYS to EYW?
Usually you’ll find the largest variety of flight choices on a Friday. Tuesdays tend to be the quietest.* But this can change depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?
To land at Key West Intl. Airport (EYW) on time, pick a flight that leaves McGhee Tyson Airport (TYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW) last-minute?
Holding off until right before your break to book a flight from TYS to EYW generally means paying more. While you may come across some last-minute offers, there’s no guarantee. Keep your travel plans flexible for the best chance of snagging a bargain.
Is it cheaper to book a TYS to EYW flight and hotel package?
You can save money by booking a TYS to EYW flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it’s simple to manage everything in one convenient place. Once you’ve chosen your preferred accommodations and flights, you can add extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Key West Intl. Airport (EYW)?
If you reserved your TYS to EYW flight within the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.
*Available to One Key members.