$104 Cheap Flights from Knoxville (TYS) to Detroit (DTW)

View $104 flight on Thu, May 29, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Knoxville to Detroit (TYS-DTW)

Prices were available within the past 7 days and start at $104 for one-way flights and $220 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Frontier Airlines
Thu, May 29 - Sun, Jun 1
TYS
Knoxville
DTW
Detroit
$220 Roundtrip, found 1 hour ago
$220
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Thu, May 29 from Knoxville to Detroit, returning Sun, Jun 1, priced at $220 found 1 hour ago
Frontier Airlines
Sun, Jun 1 - Thu, Jun 5
TYS
Knoxville
DTW
Detroit
$230 Roundtrip, found 1 hour ago
$230
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Sun, Jun 1 from Knoxville to Detroit, returning Thu, Jun 5, priced at $230 found 1 hour ago
Frontier Airlines
Sun, May 25 - Thu, Jun 12
TYS
Knoxville
DTW
Detroit
$231 Roundtrip, found 12 hours ago
$231
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Sun, May 25 from Knoxville to Detroit, returning Thu, Jun 12, priced at $231 found 12 hours ago
Frontier Airlines
Thu, May 22 - Thu, Jun 12
TYS
Knoxville
DTW
Detroit
$241 Roundtrip, found 12 hours ago
$241
Roundtrip
found 12 hours ago
Select Frontier Airlines flight, departing Thu, May 22 from Knoxville to Detroit, returning Thu, Jun 12, priced at $241 found 12 hours ago
Frontier Airlines
Sun, Jul 13 - Sun, Jul 20
TYS
Knoxville
DTW
Detroit
$252 Roundtrip, found 1 day ago
$252
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, Jul 13 from Knoxville to Detroit, returning Sun, Jul 20, priced at $252 found 1 day ago
Frontier Airlines
Sun, Jun 1 - Thu, Jun 5
TYS
Knoxville
DTW
Detroit
$260 Roundtrip, found 6 days ago
$260
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Sun, Jun 1 from Knoxville to Detroit, returning Thu, Jun 5, priced at $260 found 6 days ago
American Airlines
Wed, May 14 - Wed, May 28
TYS
Knoxville
DTW
Detroit
$275 Roundtrip, found 2 days ago
$275
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, May 14 from Knoxville to Detroit, returning Wed, May 28, priced at $275 found 2 days ago
Frontier Airlines
Thu, May 29 - Sun, Jun 8
TYS
Knoxville
DTW
Detroit
$280 Roundtrip, found 1 hour ago
$280
Roundtrip
found 1 hour ago
Select Frontier Airlines flight, departing Thu, May 29 from Knoxville to Detroit, returning Sun, Jun 8, priced at $280 found 1 hour ago
Delta
Wed, May 28 - Tue, Jun 3
TYS
Knoxville
DTW
Detroit
$353 Roundtrip, found 1 hour ago
$353
Roundtrip
found 1 hour ago
Select Delta flight, departing Wed, May 28 from Knoxville to Detroit, returning Tue, Jun 3, priced at $353 found 1 hour ago
United
Thu, May 15 - Tue, May 20
TYS
Knoxville
DTW
Detroit
$375 Roundtrip, found 6 hours ago
$375
Roundtrip
found 6 hours ago
Select United flight, departing Thu, May 15 from Knoxville to Detroit, returning Tue, May 20, priced at $375 found 6 hours ago
Flights from Knoxville (TYS) to Detroit (DTW)
Origin airport
McGhee Tyson
Destination airport
Detroit Metropolitan Wayne County
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Roundtrip price
$220
Distance
444 mi

Knoxville to Detroit Flights

The cheapest times to fly from Knoxville to Detroit

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Knoxville to Detroit are during the month of May. You can find some of the cheapest flights from Knoxville to Detroit with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Knoxville to Detroit

Sunday is one of the best days to book for cheap flights from Knoxville to Detroit: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Knoxville to Detroit

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Knoxville to Detroit in 2025. You can also book with separate airlines for your outbound and return journeys, from $104 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Knoxville to Detroit flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Knoxville to Detroit airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW) cost?
You can book cheap return fares starting from $399 from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Delta flight leaving TYS on May 10 2025 and touching down at DTW. The price was last updated on April 22 2025 and has not changed since.
What is the cheapest month to fly from TYS to DTW?
The cheapest flights from TYS to DTW are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW)?
You can travel nonstop from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW) on a Delta Air Lines flight.
What is the cheapest airline that flies from TYS to DTW?
Journey from TYS to DTW with Delta. This airline currently offers the cheapest one-way fare for this route, starting from $249. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from TYS on July 17 2025. Prices were last updated on April 22 2025 and have not changed since.
How many flights per day from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW)?
On average, only 1 nonstop flight departs each day from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW). Need more options? Use Expedia’s filter tool to find flights with layovers and explore a new city along the way.
What are the most popular departure times for flights from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW)?
The 7 AM departures from TYS to DTW are the busiest. Prices can be higher for these popular slots. If you’re looking to save, choose a less crowded time to fly.
What day of the week has the most flights from TYS to DTW?
Jet off on a Friday if you’re looking for the largest selection of flights from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW).
What is the earliest flight from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW)?
The earliest flight leaving McGhee Tyson Airport (TYS) is at around 7:25AM UTC-5. Board this plane and you’ll reach Detroit Metropolitan Wayne County Airport (DTW) at approximately 9:15AM UTC-5. The total travel time is 1h 50m.
How long does it take to fly from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW)?
Flights from TYS to DTW have an average travel time of 1 hour and 50 minutes. The total distance between the two airports is 450 mi.
What airline has the least delays from TYS to DTW?
Delta Air Lines has the best track record for on-time direct flights from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW), with an on-time score of 82%. Use the Expedia App to view your flight status before you leave and get real-time alerts about any changes.
What is the best time to fly from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW)?
To reach Detroit Metropolitan Wayne County Airport (DTW) on schedule, pick a flight that leaves from McGhee Tyson Airport (TYS) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Detroit from McGhee Tyson Airport (TYS)?
Check out your flight options from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW). This is the only airport in Detroit you can arrive at if you’re taking a direct flight.
Is it cheaper to buy a plane ticket from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW) last-minute?
Booking your flight from TYS to DTW shortly before your journey is generally more expensive. However, if there’s some wiggle room with your departure dates and times, you could land a cheap last-minute fare.
Is it cheaper to book a TYS to DTW flight and hotel package?
Securing a TYS to DTW flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Pick from our impressive range of stays and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from McGhee Tyson Airport (TYS) to Detroit Metropolitan Wayne County Airport (DTW)?
Typically, you’re able to reschedule or cancel your TYS to DTW flight. However, there may be additional charges, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline’s fees and rules on flight changes, or if you’d like further information, head to our Customer Service portal.

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*Available to One Key members.