$64 Cheap Flights from Tampa (TPA) to St. Louis (STL)

View $64 flight on Thu, May 22, 2025Opens in a new window

Popular airlines from Tampa Intl. Airport (TPA) to St. Louis Lambert Intl. Airport (STL)

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key
Find available prices by choosing your travel dates.

Cheap Flights from Tampa to St. Louis (TPA-STL)

Prices were available within the past 7 days and start at $64 for one-way flights and $137 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Spirit Airlines
Thu, May 15 - Sat, May 17
TPA
Tampa
STL
St. Louis
$137 Roundtrip, found 1 day ago
$137
Roundtrip
found 1 day ago
Select Spirit Airlines flight, departing Thu, May 15 from Tampa to St. Louis, returning Sat, May 17, priced at $137 found 1 day ago
Spirit Airlines
Sat, May 10 - Sat, May 17
TPA
Tampa
STL
St. Louis
$157 Roundtrip, found 4 hours ago
$157
Roundtrip
found 4 hours ago
Select Spirit Airlines flight, departing Sat, May 10 from Tampa to St. Louis, returning Sat, May 17, priced at $157 found 4 hours ago
Spirit Airlines
Thu, May 8 - Sat, May 17
TPA
Tampa
STL
St. Louis
$162 Roundtrip, found 10 hours ago
$162
Roundtrip
found 10 hours ago
Select Spirit Airlines flight, departing Thu, May 8 from Tampa to St. Louis, returning Sat, May 17, priced at $162 found 10 hours ago
Spirit Airlines
Sat, May 24 - Sat, May 31
TPA
Tampa
STL
St. Louis
$164 Roundtrip, found 2 hours ago
$164
Roundtrip
found 2 hours ago
Select Spirit Airlines flight, departing Sat, May 24 from Tampa to St. Louis, returning Sat, May 31, priced at $164 found 2 hours ago
Spirit Airlines
Thu, May 22 - Sun, May 25
TPA
Tampa
STL
St. Louis
$164 Roundtrip, found 9 hours ago
$164
Roundtrip
found 9 hours ago
Select Spirit Airlines flight, departing Thu, May 22 from Tampa to St. Louis, returning Sun, May 25, priced at $164 found 9 hours ago
Spirit Airlines
Sat, May 24 - Sat, Jun 7
TPA
Tampa
STL
St. Louis
$167 Roundtrip, found 5 days ago
$167
Roundtrip
found 5 days ago
Select Spirit Airlines flight, departing Sat, May 24 from Tampa to St. Louis, returning Sat, Jun 7, priced at $167 found 5 days ago
Frontier Airlines
Thu, May 8 - Sat, May 17
TPA
Tampa
STL
St. Louis
$180 Roundtrip, found 10 hours ago
$180
Roundtrip
found 10 hours ago
Select Frontier Airlines flight, departing Thu, May 8 from Tampa to St. Louis, returning Sat, May 17, priced at $180 found 10 hours ago
United
Wed, May 14 - Sat, May 17
TPA
Tampa
STL
St. Louis
$194 Roundtrip, found 5 hours ago
$194
Roundtrip
found 5 hours ago
Select United flight, departing Wed, May 14 from Tampa to St. Louis, returning Sat, May 17, priced at $194 found 5 hours ago
Delta
Wed, May 14 - Sat, May 17
TPA
Tampa
STL
St. Louis
$199 Roundtrip, found 5 hours ago
$199
Roundtrip
found 5 hours ago
Select Delta flight, departing Wed, May 14 from Tampa to St. Louis, returning Sat, May 17, priced at $199 found 5 hours ago
Southwest Airlines
Wed, May 14 - Sat, May 17
TPA
Tampa
STL
St. Louis
$205 Roundtrip, found 5 hours ago
$205
Roundtrip
found 5 hours ago
Select Southwest Airlines flight, departing Wed, May 14 from Tampa to St. Louis, returning Sat, May 17, priced at $205 found 5 hours ago
Flights from Tampa (TPA) to St. Louis (STL)
Origin airport
Tampa Intl.
Destination airport
Lambert-St. Louis Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, Southwest Airlines, Spirit Airlines, United
Roundtrip price
$137
Distance
869 mi

Tampa to St. Louis Flights

The cheapest times to fly from Tampa to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Tampa to St. Louis are during the month of May. You can find some of the cheapest flights from Tampa to St. Louis with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Tampa to St. Louis

Sunday is one of the best days to book for cheap flights from Tampa to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Tampa to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Tampa to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $64 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Tampa to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Tampa to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL) cost?
Cheap round-trip fares from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL) start at $287. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Southwest Airlines flight leaving TPA on May 13 2025 and touching down at STL. The price was last updated on April 22 2025 and has not changed since.
What is the cheapest month to fly from TPA to STL?
The cheapest flights from TPA to STL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL)?
When jetting out of Tampa Intl. Airport (TPA), you can jump on a direct flight to Lambert-St. Louis Intl. Airport (STL) with Southwest Airlines.
What is the cheapest airline that flies from TPA to STL?
Fly from TPA to STL with Southwest Airlines. This airline currently offers the lowest one-way fare on this route, starting from $144. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from TPA on June 10 2025. Prices were last updated on April 22 2025 and have not changed since.
How many flights per day from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL)?
Each day, an average of 3 nonstop flights take off from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL). Select the departure date that best fits your schedule.
What are the most popular departure times for flights from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL)?
More people fly between TPA and STL at 8 AM than at any other time. Looking for a quieter experience? Travel outside of rush hours and you could save on your fare as well.
What day of the week has the most flights from TPA to STL?
Depart on a Friday if you’re looking for the largest selection of flights from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL).
What is the earliest flight from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL)?
Tampa Intl. Airport (TPA)’s earliest flight to Lambert-St. Louis Intl. Airport (STL) leaves at approximately 6:55AM UTC-5. With a travel duration of 2h 35m, you’ll arrive at around 8:30AM UTC-6.
How long does it take to fly from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL)?
Flights from TPA to STL have an average travel time of 2 hours and 33 minutes. The distance between the two is 870 mi.
What is the best time to fly from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL)?
To arrive at Lambert-St. Louis Intl. Airport (STL) without delays, select a flight that leaves Tampa Intl. Airport (TPA) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for St. Louis from Tampa Intl. Airport (TPA)?
Lambert-St. Louis Intl. Airport (STL) is the only airport in St. Louis with direct flights from Tampa Intl. Airport (TPA). Consider the available options and find affordable fares on Expedia.
Is it cheaper to buy a plane ticket from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Booking your plane ticket from TPA to STL right before your trip is generally more expensive. However, if you’re flexible with your travel times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a TPA to STL flight and hotel package?
Opting for a TPA to STL flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Pick from our impressive range of stays and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Tampa Intl. Airport (TPA) to Lambert-St. Louis Intl. Airport (STL)?
Typically, you can cancel or reschedule your TPA to STL flight. However, additional charges may apply, especially if you booked more than 24 hours ago. Check your itinerary for the airline’s policies and fees on flight changes, or if you want further information, go to our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.