$100 Cheap Flights from Syracuse (SYR) to Knoxville (TYS)

View $100 flight on Sat, May 31, 2025Opens in a new window

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key
Find available prices by choosing your travel dates.

Cheap Flights from Syracuse to Knoxville (SYR-TYS)

Prices were available within the past 7 days and start at $100 for one-way flights and $202 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Sat, May 24 - Sat, May 31
SYR
Syracuse
TYS
Knoxville
$202 Roundtrip, found 18 hours ago
$202
Roundtrip
found 18 hours ago
Select United flight, departing Sat, May 24 from Syracuse to Knoxville, returning Sat, May 31, priced at $202 found 18 hours ago
Delta
Wed, May 28 - Fri, May 30
SYR
Syracuse
TYS
Knoxville
$217 Roundtrip, found 16 hours ago
$217
Roundtrip
found 16 hours ago
Select Delta flight, departing Wed, May 28 from Syracuse to Knoxville, returning Fri, May 30, priced at $217 found 16 hours ago
American Airlines
Fri, May 30 - Mon, Jun 2
SYR
Syracuse
TYS
Knoxville
$224 Roundtrip, found 16 hours ago
$224
Roundtrip
found 16 hours ago
Select American Airlines flight, departing Fri, May 30 from Syracuse to Knoxville, returning Mon, Jun 2, priced at $224 found 16 hours ago
American Airlines
Wed, May 21 - Wed, May 28
SYR
Syracuse
TYS
Knoxville
$225 Roundtrip, found 12 hours ago
$225
Roundtrip
found 12 hours ago
Select American Airlines flight, departing Wed, May 21 from Syracuse to Knoxville, returning Wed, May 28, priced at $225 found 12 hours ago
Delta
Wed, May 21 - Wed, May 28
SYR
Syracuse
TYS
Knoxville
$226 Roundtrip, found 12 hours ago
$226
Roundtrip
found 12 hours ago
Select Delta flight, departing Wed, May 21 from Syracuse to Knoxville, returning Wed, May 28, priced at $226 found 12 hours ago
American Airlines
Sat, May 24 - Tue, May 27
SYR
Syracuse
TYS
Knoxville
$228 Roundtrip, found 1 day ago
$228
Roundtrip
found 1 day ago
Select American Airlines flight, departing Sat, May 24 from Syracuse to Knoxville, returning Tue, May 27, priced at $228 found 1 day ago
Delta
Wed, May 28 - Mon, Jun 2
SYR
Syracuse
TYS
Knoxville
$233 Roundtrip, found 16 hours ago
$233
Roundtrip
found 16 hours ago
Select Delta flight, departing Wed, May 28 from Syracuse to Knoxville, returning Mon, Jun 2, priced at $233 found 16 hours ago
Delta
Tue, May 27 - Fri, May 30
SYR
Syracuse
TYS
Knoxville
$234 Roundtrip, found 16 hours ago
$234
Roundtrip
found 16 hours ago
Select Delta flight, departing Tue, May 27 from Syracuse to Knoxville, returning Fri, May 30, priced at $234 found 16 hours ago
United
Wed, May 21 - Wed, May 28
SYR
Syracuse
TYS
Knoxville
$236 Roundtrip, found 12 hours ago
$236
Roundtrip
found 12 hours ago
Select United flight, departing Wed, May 21 from Syracuse to Knoxville, returning Wed, May 28, priced at $236 found 12 hours ago
United
Sat, May 24 - Sat, May 31
SYR
Syracuse
TYS
Knoxville
$237 Roundtrip, found 18 hours ago
$237
Roundtrip
found 18 hours ago
Select United flight, departing Sat, May 24 from Syracuse to Knoxville, returning Sat, May 31, priced at $237 found 18 hours ago
Flights from Syracuse (SYR) to Knoxville (TYS)
Origin airport
Hancock Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, United
Roundtrip price
$201
Distance
656 mi

Syracuse to Knoxville Flights

The cheapest times to fly from Syracuse to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Syracuse to Knoxville are during the month of May. You can find some of the cheapest flights from Syracuse to Knoxville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Syracuse to Knoxville

Sunday is one of the best days to book for cheap flights from Syracuse to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Syracuse to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Syracuse to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $100 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Syracuse to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Syracuse to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Hancock Intl. Airport (SYR) to McGhee Tyson Airport (TYS) cost?
Discover the latest flight deals from SYR to TYS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from SYR to TYS?
The cheapest flights from SYR to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from SYR to TYS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from SYR to TYS. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Hancock Intl. Airport (SYR) to McGhee Tyson Airport (TYS)?
Nonstop flights from Hancock Intl. Airport (SYR) to McGhee Tyson Airport (TYS) aren’t available daily, so you’ll have to take a flight with a layover. Explore your options with Expedia’s filters. Enter your dates and select either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from SYR to TYS?
Usually you’ll find the most flight options available on a Friday. Tuesdays are often the quietest.* However, this can vary depending on the airline, season and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Hancock Intl. Airport (SYR) to McGhee Tyson Airport (TYS)?
Opt for a flight from Hancock Intl. Airport (SYR) to McGhee Tyson Airport (TYS) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Hancock Intl. Airport (SYR) to McGhee Tyson Airport (TYS) last-minute?
Booking your ticket from SYR to TYS right before your journey is typically more expensive. But if there’s some wiggle room with your schedule, you could bag a cheap last-minute fare.
Is it cheaper to book a SYR to TYS flight and hotel package?
You can save money by booking a SYR to TYS flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it’s easy to manage it all in one convenient place. After selecting your preferred accommodations and flights, consider adding extras including car rentals, activities and tours.
Can I cancel or change the date of my flight from Hancock Intl. Airport (SYR) to McGhee Tyson Airport (TYS)?
In most cases, you’re able to cancel or reschedule your SYR to TYS flight. However, additional charges may apply, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline’s fees and policies on flight changes, or if you need more information, visit our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.