Cheap Flights from St. Louis (SUS) to Knoxville (TYS)

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Find available prices by choosing your travel dates.
Flights from St. Louis (SUS) to Knoxville (TYS)
Origin airport
Spirit of St. Louis
Destination airport
McGhee Tyson
Distance
415 mi

St. Louis to Knoxville Flights

The cheapest times to fly from St. Louis to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Knoxville are during the month of . You can find some of the cheapest flights from St. Louis to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from St. Louis to Knoxville

Sunday is one of the best days to book for cheap flights from St. Louis to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from St. Louis to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Spirit of St. Louis Airport (SUS) to McGhee Tyson Airport (TYS) cost?
Discover the latest flight deals from SUS to TYS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from SUS to TYS?
The cheapest flights from SUS to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from SUS to TYS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from SUS to TYS. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Spirit of St. Louis Airport (SUS) to McGhee Tyson Airport (TYS)?
You’ll need to book a flight with a layover if you’re traveling from Spirit of St. Louis Airport (SUS) to McGhee Tyson Airport (TYS). Direct flights don’t operate daily on this route. However, just filter your search to include one or more stops to discover the best option for your trip.
What day of the week has the most flights from SUS to TYS?
You’ll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Spirit of St. Louis Airport (SUS) to McGhee Tyson Airport (TYS)?
Select a flight from Spirit of St. Louis Airport (SUS) to McGhee Tyson Airport (TYS) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Spirit of St. Louis Airport (SUS) to McGhee Tyson Airport (TYS) last-minute?
Booking your plane ticket from SUS to TYS right before your journey is typically more expensive. But if there’s some wiggle room with your departure times and dates, you could score a cheap last-minute fare.
Is it cheaper to book a SUS to TYS flight and hotel package?
You’ll typically save money by booking a SUS to TYS flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it’s easy to manage it all in one convenient place. After selecting your ideal accommodations and flights, consider adding extras including activities, car rentals and tours.
Can I cancel or change the date of my flight from Spirit of St. Louis Airport (SUS) to McGhee Tyson Airport (TYS)?
If you reserved your SUS to TYS flight in the last 24 hours, you may be able to cancel or modify it without fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for further details.

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*Available to One Key members.