$460 Cheap Flights from St. Louis (STL) to Santiago (SCL)

View $460 flight on Sun, Nov 23, 2025Opens in a new window

Popular airlines from St. Louis Lambert Intl. Airport (STL) to Santiago Intl. Airport (SCL)

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key
Find available prices by choosing your travel dates.

Cheap Flights from St. Louis to Santiago (STL-SCL)

Prices were available within the past 7 days and start at $460 for one-way flights and $804 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Sep 1 - Mon, Sep 15
STL
St. Louis
SCL
Santiago
$804 Roundtrip, found 9 hours ago
$804
Roundtrip
found 9 hours ago
Select Delta flight, departing Mon, Sep 1 from St. Louis to Santiago, returning Mon, Sep 15, priced at $804 found 9 hours ago
United
Wed, Nov 5 - Wed, Nov 19
STL
St. Louis
SCL
Santiago
$804 Roundtrip, found 14 hours ago
$804
Roundtrip
found 14 hours ago
Select United flight, departing Wed, Nov 5 from St. Louis to Santiago, returning Wed, Nov 19, priced at $804 found 14 hours ago
American Airlines
Mon, Sep 1 - Mon, Sep 15
STL
St. Louis
SCL
Santiago
$808 Roundtrip, found 9 hours ago
$808
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Mon, Sep 1 from St. Louis to Santiago, returning Mon, Sep 15, priced at $808 found 9 hours ago
Delta
Sun, Nov 2 - Mon, Nov 17
STL
St. Louis
SCL
Santiago
$812 Roundtrip, found 5 days ago
$812
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Nov 2 from St. Louis to Santiago, returning Mon, Nov 17, priced at $812 found 5 days ago
American Airlines
Mon, Sep 8 - Tue, Nov 11
STL
St. Louis
SCL
Santiago
$814 Roundtrip, found 2 days ago
$814
Roundtrip
found 2 days ago
Select American Airlines flight, departing Mon, Sep 8 from St. Louis to Santiago, returning Tue, Nov 11, priced at $814 found 2 days ago
Delta
Sun, Nov 30 - Mon, Dec 15
STL
St. Louis
SCL
Santiago
$816 Roundtrip, found 5 days ago
$816
Roundtrip
found 5 days ago
Select Delta flight, departing Sun, Nov 30 from St. Louis to Santiago, returning Mon, Dec 15, priced at $816 found 5 days ago
American Airlines
Mon, Sep 1 - Mon, Sep 15
STL
St. Louis
SCL
Santiago
$819 Roundtrip, found 9 hours ago
$819
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Mon, Sep 1 from St. Louis to Santiago, returning Mon, Sep 15, priced at $819 found 9 hours ago
Delta
Thu, Oct 2 - Tue, Nov 4
STL
St. Louis
SCL
Santiago
$819 Roundtrip, found 2 days ago
$819
Roundtrip
found 2 days ago
Select Delta flight, departing Thu, Oct 2 from St. Louis to Santiago, returning Tue, Nov 4, priced at $819 found 2 days ago
LATAM Airlines Group
Thu, Oct 2 - Tue, Nov 4
STL
St. Louis
SCL
Santiago
$855 Roundtrip, found 2 days ago
$855
Roundtrip
found 2 days ago
Select LATAM Airlines Group flight, departing Thu, Oct 2 from St. Louis to Santiago, returning Tue, Nov 4, priced at $855 found 2 days ago
Copa
Mon, Oct 6 - Wed, Jan 21
STL
St. Louis
SCL
Santiago
$1,013 Roundtrip, found 5 days ago
$1,013
Roundtrip
found 5 days ago
Select Copa flight, departing Mon, Oct 6 from St. Louis to Santiago, returning Wed, Jan 21, priced at $1,013 found 5 days ago

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL) cost?
Discover the latest flight deals from STL to SCL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from STL to SCL?
The cheapest flights from STL to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from STL to SCL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from STL to SCL. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
There are no daily direct flights departing from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL). But you can choose flights with layovers. Filter your search results on Expedia to include one or two stops, and you’ll be on your way in no time at all.
What day of the week has the most flights from STL to SCL?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can change depending on a range of factors, including the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
To touch down at Arturo Merino Benitez Airport (SCL) on schedule, pick a flight that takes off from Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your flight from STL to SCL right before your journey is usually more expensive. However, if you’re flexible with your schedule, you could score a cheap last-minute fare.
Is it cheaper to book a STL to SCL flight and hotel package?
You’ll generally save money by securing a STL to SCL flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it’s easy to manage everything in one convenient place. After selecting your preferred accommodations and flights, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Arturo Merino Benitez Airport (SCL)?
You can usually cancel or reschedule your STL to SCL flight. However, if it’s been more than 24 hours since booking, additional fees may apply. Check your airline’s policies in your itinerary to see what changes are possible and if any costs are involved. You’ll also find further details on our Customer Service portal.
*Available to One Key members.