$154 Cheap Flights from St. Louis (STL) to Panama City (PTY)

View $154 flight on Sun, Aug 10, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from St. Louis to Panama City (STL-PTY)

Prices were available within the past 7 days and start at $154 for one-way flights and $373 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, Aug 20 - Mon, Aug 25
STL
St. Louis
PTY
Panama City
$373 Roundtrip, found 9 hours ago
$373
Roundtrip
found 9 hours ago
Select Delta flight, departing Wed, Aug 20 from St. Louis to Panama City, returning Mon, Aug 25, priced at $373 found 9 hours ago
United
Mon, Aug 4 - Thu, Aug 7
STL
St. Louis
PTY
Panama City
$373 Roundtrip, found 9 hours ago
$373
Roundtrip
found 9 hours ago
Select United flight, departing Mon, Aug 4 from St. Louis to Panama City, returning Thu, Aug 7, priced at $373 found 9 hours ago
American Airlines
Wed, Jul 9 - Thu, Jul 17
STL
St. Louis
PTY
Panama City
$378 Roundtrip, found 14 hours ago
$378
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Wed, Jul 9 from St. Louis to Panama City, returning Thu, Jul 17, priced at $378 found 14 hours ago
Delta
Sun, Jun 22 - Tue, Jul 1
STL
St. Louis
PTY
Panama City
$380 Roundtrip, just found
$380
Roundtrip
just found
Select Delta flight, departing Sun, Jun 22 from St. Louis to Panama City, returning Tue, Jul 1, priced at $380 just found
United
Wed, Aug 20 - Mon, Aug 25
STL
St. Louis
PTY
Panama City
$381 Roundtrip, found 9 hours ago
$381
Roundtrip
found 9 hours ago
Select United flight, departing Wed, Aug 20 from St. Louis to Panama City, returning Mon, Aug 25, priced at $381 found 9 hours ago
United
Wed, Jul 9 - Thu, Jul 17
STL
St. Louis
PTY
Panama City
$386 Roundtrip, found 14 hours ago
$386
Roundtrip
found 14 hours ago
Select United flight, departing Wed, Jul 9 from St. Louis to Panama City, returning Thu, Jul 17, priced at $386 found 14 hours ago
American Airlines
Mon, Jun 2 - Mon, Jun 9
STL
St. Louis
PTY
Panama City
$387 Roundtrip, found 5 days ago
$387
Roundtrip
found 5 days ago
Select American Airlines flight, departing Mon, Jun 2 from St. Louis to Panama City, returning Mon, Jun 9, priced at $387 found 5 days ago
American Airlines
Wed, Aug 20 - Mon, Aug 25
STL
St. Louis
PTY
Panama City
$390 Roundtrip, found 9 hours ago
$390
Roundtrip
found 9 hours ago
Select American Airlines flight, departing Wed, Aug 20 from St. Louis to Panama City, returning Mon, Aug 25, priced at $390 found 9 hours ago
avianca
Tue, May 6 - Tue, May 13
STL
St. Louis
PTY
Panama City
$979 Roundtrip, found 2 days ago
$979
Roundtrip
found 2 days ago
Select avianca flight, departing Tue, May 6 from St. Louis to Panama City, returning Tue, May 13, priced at $979 found 2 days ago
Copa
Sun, Aug 24 - Sat, Aug 30
STL
St. Louis
PTY
Panama City
$1,241 Roundtrip, found 1 day ago
$1,241
Roundtrip
found 1 day ago
Select Copa flight, departing Sun, Aug 24 from St. Louis to Panama City, returning Sat, Aug 30, priced at $1,241 found 1 day ago
Flights from St. Louis (STL) to Panama City (PTY)
Origin airport
Lambert-St. Louis Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$373
Distance
2160 mi

St. Louis to Panama City Flights

The cheapest times to fly from St. Louis to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from St. Louis to Panama City are during the month of August. You can find some of the cheapest flights from St. Louis to Panama City with Expedia's search tool and vast selection of airlines.

The best time to book a flight from St. Louis to Panama City

Sunday is one of the best days to book for cheap flights from St. Louis to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from St. Louis to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from St. Louis to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $154 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap St. Louis to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your St. Louis to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from STL to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from STL to PTY?
The cheapest flights from STL to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from STL to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from STL to PTY. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY)?
Direct flights from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY) aren’t available daily, so you’ll have to take a flight with a layover. Explore your options with Expedia’s filter tool. Enter your dates and pick either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from STL to PTY?
Friday is typically the busiest day for flights, while Tuesday is often the quietest.* Keep in mind that flight schedules can vary based on a range of factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY)?
To land at Tocumen Intl. Airport (PTY) without delays, choose a flight that leaves from Lambert-St. Louis Intl. Airport (STL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY) last-minute?
Waiting until just before your departure to book a ticket from STL to PTY generally means paying more. While it’s possible to find some last-minute discounts, they aren’t always guaranteed. Keep your travel schedule open to boost your chances of snagging a bargain.
Is it cheaper to book a STL to PTY flight and hotel package?
Securing a STL to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our impressive range of stays and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Lambert-St. Louis Intl. Airport (STL) to Tocumen Intl. Airport (PTY)?
If you booked your STL to PTY flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

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*Available to One Key members.