$310 Cheap Flights from San Francisco (SFO) to Santiago (SCL)

View $310 flight on Wed, Aug 13, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from San Francisco to Santiago (SFO-SCL)

Prices were available within the past 7 days and start at $310 for one-way flights and $664 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, Nov 24 - Wed, Dec 3
SFO
San Francisco
SCL
Santiago
$664 Roundtrip, just found
$664
Roundtrip
just found
Select American Airlines flight, departing Mon, Nov 24 from San Francisco to Santiago, returning Wed, Dec 3, priced at $664 just found
Delta
Mon, Nov 24 - Wed, Dec 3
SFO
San Francisco
SCL
Santiago
$664 Roundtrip, just found
$664
Roundtrip
just found
Select Delta flight, departing Mon, Nov 24 from San Francisco to Santiago, returning Wed, Dec 3, priced at $664 just found
United
Wed, Feb 4 - Wed, Feb 25
SFO
San Francisco
SCL
Santiago
$664 Roundtrip, found 12 hours ago
$664
Roundtrip
found 12 hours ago
Select United flight, departing Wed, Feb 4 from San Francisco to Santiago, returning Wed, Feb 25, priced at $664 found 12 hours ago
American Airlines
Mon, Nov 24 - Wed, Dec 3
SFO
San Francisco
SCL
Santiago
$668 Roundtrip, just found
$668
Roundtrip
just found
Select American Airlines flight, departing Mon, Nov 24 from San Francisco to Santiago, returning Wed, Dec 3, priced at $668 just found
American Airlines
Sun, Nov 23 - Tue, Dec 2
SFO
San Francisco
SCL
Santiago
$674 Roundtrip, just found
$674
Roundtrip
just found
Select American Airlines flight, departing Sun, Nov 23 from San Francisco to Santiago, returning Tue, Dec 2, priced at $674 just found
Delta
Mon, Mar 2 - Mon, Mar 9
SFO
San Francisco
SCL
Santiago
$677 Roundtrip, found 1 hour ago
$677
Roundtrip
found 1 hour ago
Select Delta flight, departing Mon, Mar 2 from San Francisco to Santiago, returning Mon, Mar 9, priced at $677 found 1 hour ago
American Airlines
Mon, Nov 24 - Wed, Dec 3
SFO
San Francisco
SCL
Santiago
$677 Roundtrip, just found
$677
Roundtrip
just found
Select American Airlines flight, departing Mon, Nov 24 from San Francisco to Santiago, returning Wed, Dec 3, priced at $677 just found
Copa
Sun, Jun 22 - Thu, Jul 3
SFO
San Francisco
SCL
Santiago
$678 Roundtrip, found 4 hours ago
$678
Roundtrip
found 4 hours ago
Select Copa flight, departing Sun, Jun 22 from San Francisco to Santiago, returning Thu, Jul 3, priced at $678 found 4 hours ago
American Airlines
Mon, Nov 24 - Wed, Dec 3
SFO
San Francisco
SCL
Santiago
$682 Roundtrip, just found
$682
Roundtrip
just found
Select American Airlines flight, departing Mon, Nov 24 from San Francisco to Santiago, returning Wed, Dec 3, priced at $682 just found
LATAM Airlines Group
Mon, Nov 24 - Wed, Dec 3
SFO
San Francisco
SCL
Santiago
$716 Roundtrip, just found
$716
Roundtrip
just found
Select LATAM Airlines Group flight, departing Mon, Nov 24 from San Francisco to Santiago, returning Wed, Dec 3, priced at $716 just found

Frequently asked questions

How much does a flight from San Francisco Intl. Airport (SFO) to Arturo Merino Benitez Airport (SCL) cost?
Discover the latest flight deals from SFO to SCL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from SFO to SCL?
The cheapest flights from SFO to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from SFO to SCL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from SFO to SCL. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from San Francisco Intl. Airport (SFO) to Arturo Merino Benitez Airport (SCL)?
Nonstop flights from San Francisco Intl. Airport (SFO) to Arturo Merino Benitez Airport (SCL) aren’t available daily, so you’ll need to take a flight with a layover. Explore your options with our filter tool. Enter your dates and click on either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from SFO to SCL?
Generally you’ll find the greatest selection of flight options on a Friday. Tuesdays are often the quietest.* However, this can change based on the time of year, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from San Francisco Intl. Airport (SFO) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the San Francisco Intl. Airport (SFO) to Arturo Merino Benitez Airport (SCL) route, travel before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from San Francisco Intl. Airport (SFO) to Arturo Merino Benitez Airport (SCL) last-minute?
Holding off until right before your break to book a flight from SFO to SCL generally means paying more. While you might find some last-minute discounts, they’re not always guaranteed. Keep your travel plans flexible to maximize your chances of snagging a bargain.
Is it cheaper to book a SFO to SCL flight and hotel package?
You’ll typically save money by booking a SFO to SCL flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it’s simple to manage it all in one place. After choosing your preferred accommodations and flights, you can add extras like activities, car rentals and tours.
Can I cancel or change the date of my flight from San Francisco Intl. Airport (SFO) to Arturo Merino Benitez Airport (SCL)?
Generally, it’s possible to reschedule or cancel your SFO to SCL flight. However, if it’s been more than 24 hours since booking, additional fees may apply. Check your airline’s policies in your itinerary to see what changes are possible and whether any costs are involved. You’ll also find further details on our Customer Service portal.
*Available to One Key members.