$260 Cheap Flights from Santo Domingo (SDQ) to San Francisco (SFO)

View $260 flight on Thu, Jun 5, 2025Opens in a new window
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Cheap Flights from Santo Domingo to San Francisco (SDQ-SFO)

Prices were available within the past 7 days and start at $260 for one-way flights and $476 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Tue, May 20 - Sun, May 25
SDQ
Santo Domingo
SFO
San Francisco
$476 Roundtrip, found 2 days ago
$476
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Tue, May 20 from Santo Domingo to San Francisco, returning Sun, May 25, priced at $476 found 2 days ago
JetBlue Airways
Fri, May 23 - Sun, May 25
SDQ
Santo Domingo
SFO
San Francisco
$496 Roundtrip, found 2 days ago
$496
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Fri, May 23 from Santo Domingo to San Francisco, returning Sun, May 25, priced at $496 found 2 days ago
JetBlue Airways
Thu, May 29 - Tue, Aug 26
SDQ
Santo Domingo
SFO
San Francisco
$504 Roundtrip, found 3 days ago
$504
Roundtrip
found 3 days ago
Select JetBlue Airways flight, departing Thu, May 29 from Santo Domingo to San Francisco, returning Tue, Aug 26, priced at $504 found 3 days ago
Frontier Airlines
Thu, Jun 5 - Mon, Jul 28
SDQ
Santo Domingo
SFO
San Francisco
$505 Roundtrip, found 3 days ago
$505
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, Jun 5 from Santo Domingo to San Francisco, returning Mon, Jul 28, priced at $505 found 3 days ago
Frontier Airlines
Thu, Jun 5 - Wed, Jul 23
SDQ
Santo Domingo
SFO
San Francisco
$506 Roundtrip, found 3 days ago
$506
Roundtrip
found 3 days ago
Select Frontier Airlines flight, departing Thu, Jun 5 from Santo Domingo to San Francisco, returning Wed, Jul 23, priced at $506 found 3 days ago
Frontier Airlines
Thu, Jun 5 - Wed, Jun 11
SDQ
Santo Domingo
SFO
San Francisco
$508 Roundtrip, found 6 days ago
$508
Roundtrip
found 6 days ago
Select Frontier Airlines flight, departing Thu, Jun 5 from Santo Domingo to San Francisco, returning Wed, Jun 11, priced at $508 found 6 days ago
Frontier Airlines
Thu, Jul 3 - Fri, Jul 18
SDQ
Santo Domingo
SFO
San Francisco
$513 Roundtrip, found 5 hours ago
$513
Roundtrip
found 5 hours ago
Select Frontier Airlines flight, departing Thu, Jul 3 from Santo Domingo to San Francisco, returning Fri, Jul 18, priced at $513 found 5 hours ago
Copa
Tue, Sep 23 - Tue, Sep 30
SDQ
Santo Domingo
SFO
San Francisco
$560 Roundtrip, found 2 hours ago
$560
Roundtrip
found 2 hours ago
Select Copa flight, departing Tue, Sep 23 from Santo Domingo to San Francisco, returning Tue, Sep 30, priced at $560 found 2 hours ago
American Airlines
Tue, Sep 9 - Tue, Sep 16
SDQ
Santo Domingo
SFO
San Francisco
$690 Roundtrip, just found
$690
Roundtrip
just found
Select American Airlines flight, departing Tue, Sep 9 from Santo Domingo to San Francisco, returning Tue, Sep 16, priced at $690 just found
Delta
Tue, Sep 9 - Tue, Sep 16
SDQ
Santo Domingo
SFO
San Francisco
$690 Roundtrip, just found
$690
Roundtrip
just found
Select Delta flight, departing Tue, Sep 9 from Santo Domingo to San Francisco, returning Tue, Sep 16, priced at $690 just found
Flights from Santo Domingo (SDQ) to San Francisco (SFO)
Origin airport
Las Americas Intl.
Destination airport
San Francisco Intl.
Airlines serving
Aeromexico, American Airlines, Copa, Delta, Frontier Airlines, JetBlue Airways, United, avianca
Roundtrip price
$475
Distance
3426 mi

Santo Domingo to San Francisco Flights

The cheapest times to fly from Santo Domingo to San Francisco

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santo Domingo to San Francisco are during the month of May. You can find some of the cheapest flights from Santo Domingo to San Francisco with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Santo Domingo to San Francisco

Sunday is one of the best days to book for cheap flights from Santo Domingo to San Francisco: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Santo Domingo to San Francisco

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santo Domingo to San Francisco in 2025. You can also book with separate airlines for your outbound and return journeys, from $260 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santo Domingo to San Francisco flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santo Domingo to San Francisco airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Las Americas Intl. Airport (SDQ) to San Francisco Intl. Airport (SFO) cost?
Discover the latest flight deals from SDQ to SFO by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from SDQ to SFO?
The cheapest flights from SDQ to SFO are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from SDQ to SFO?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from SDQ to SFO. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Las Americas Intl. Airport (SDQ) to San Francisco Intl. Airport (SFO)?
There aren’t any daily direct flights departing from Las Americas Intl. Airport (SDQ) to San Francisco Intl. Airport (SFO). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you’ll be soaring above the clouds in no time.
What day of the week has the most flights from SDQ to SFO?
You’ll usually find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Las Americas Intl. Airport (SDQ) to San Francisco Intl. Airport (SFO)?
To land at San Francisco Intl. Airport (SFO) without delays, select a flight that leaves from Las Americas Intl. Airport (SDQ) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Las Americas Intl. Airport (SDQ) to San Francisco Intl. Airport (SFO) last-minute?
Holding off until just before your trip to book a flight from SDQ to SFO often results in higher prices. Although you may find some last-minute deals, there’s no guarantee. Keep your travel schedule open for the best chance of landing a bargain.
Is it cheaper to book a SDQ to SFO flight and hotel package?
Compared with arranging flights and hotels separately, booking a SDQ to SFO flight and hotel package with Expedia could lead to significant savings. What’s more, having it all in one place takes the hassle out of travel planning. Just secure your flights and select from our extensive range of stays, then tailor your trip with extras like activities and car rentals.
Can I cancel or change the date of my flight from Las Americas Intl. Airport (SDQ) to San Francisco Intl. Airport (SFO)?
If you reserved your SDQ to SFO flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of fare you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal if you want more information.

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*Available to One Key members.