$106 Cheap Flights from Louisville (SDF) to Des Moines (DSM)

View $106 flight on Thu, May 29, 2025Opens in a new window

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key
Find available prices by choosing your travel dates.

Cheap Flights from Louisville to Des Moines (SDF-DSM)

Prices were available within the past 7 days and start at $106 for one-way flights and $229 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Sat, May 24 - Tue, May 27
SDF
Louisville
DSM
Des Moines
$229 Roundtrip, found 3 hours ago
$229
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Sat, May 24 from Louisville to Des Moines, returning Tue, May 27, priced at $229 found 3 hours ago
Delta
Sat, May 24 - Tue, May 27
SDF
Louisville
DSM
Des Moines
$229 Roundtrip, found 3 hours ago
$229
Roundtrip
found 3 hours ago
Select Delta flight, departing Sat, May 24 from Louisville to Des Moines, returning Tue, May 27, priced at $229 found 3 hours ago
Delta
Sat, May 24 - Tue, May 27
SDF
Louisville
DSM
Des Moines
$232 Roundtrip, found 3 hours ago
$232
Roundtrip
found 3 hours ago
Select Delta flight, departing Sat, May 24 from Louisville to Des Moines, returning Tue, May 27, priced at $232 found 3 hours ago
Delta
Wed, May 21 - Thu, May 29
SDF
Louisville
DSM
Des Moines
$238 Roundtrip, found 7 hours ago
$238
Roundtrip
found 7 hours ago
Select Delta flight, departing Wed, May 21 from Louisville to Des Moines, returning Thu, May 29, priced at $238 found 7 hours ago
Southwest Airlines
Wed, Jul 2 - Mon, Jul 7
SDF
Louisville
DSM
Des Moines
$239 Roundtrip, found 2 days ago
$239
Roundtrip
found 2 days ago
Select Southwest Airlines flight, departing Wed, Jul 2 from Louisville to Des Moines, returning Mon, Jul 7, priced at $239 found 2 days ago
Delta
Tue, Jul 1 - Tue, Jul 22
SDF
Louisville
DSM
Des Moines
$240 Roundtrip, found 7 hours ago
$240
Roundtrip
found 7 hours ago
Select Delta flight, departing Tue, Jul 1 from Louisville to Des Moines, returning Tue, Jul 22, priced at $240 found 7 hours ago
Southwest Airlines
Tue, Aug 19 - Fri, Aug 22
SDF
Louisville
DSM
Des Moines
$240 Roundtrip, found 3 days ago
$240
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, Aug 19 from Louisville to Des Moines, returning Fri, Aug 22, priced at $240 found 3 days ago
American Airlines
Wed, Jun 4 - Sat, Jun 7
SDF
Louisville
DSM
Des Moines
$242 Roundtrip, found 2 days ago
$242
Roundtrip
found 2 days ago
Select American Airlines flight, departing Wed, Jun 4 from Louisville to Des Moines, returning Sat, Jun 7, priced at $242 found 2 days ago
United
Sat, May 24 - Tue, May 27
SDF
Louisville
DSM
Des Moines
$243 Roundtrip, found 3 hours ago
$243
Roundtrip
found 3 hours ago
Select United flight, departing Sat, May 24 from Louisville to Des Moines, returning Tue, May 27, priced at $243 found 3 hours ago
United
Sat, May 24 - Tue, May 27
SDF
Louisville
DSM
Des Moines
$246 Roundtrip, found 3 hours ago
$246
Roundtrip
found 3 hours ago
Select United flight, departing Sat, May 24 from Louisville to Des Moines, returning Tue, May 27, priced at $246 found 3 hours ago
Flights from Louisville (SDF) to Des Moines (DSM)
Origin airport
Louisville Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$228
Distance
478 mi

Louisville to Des Moines Flights

The cheapest times to fly from Louisville to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Louisville to Des Moines are during the month of May. You can find some of the cheapest flights from Louisville to Des Moines with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Louisville to Des Moines

Sunday is one of the best days to book for cheap flights from Louisville to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Louisville to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Louisville to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $106 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Louisville to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Louisville to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from SDF to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from SDF to DSM?
The cheapest flights from SDF to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from SDF to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from SDF to DSM. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM)?
There aren’t any daily nonstop flights from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you’ll be soaring above the clouds in no time.
What day of the week has the most flights from SDF to DSM?
Friday is usually the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary based on a number of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM)?
To avoid potential delays on the Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM) route, fly before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until right before your break to book a flight from SDF to DSM generally means paying more. While you may find some last-minute discounts, they’re not always guaranteed. Keep your travel schedule open for the best chance of scoring a bargain.
Is it cheaper to book a SDF to DSM flight and hotel package?
Compared with arranging flights and hotels separately, booking a SDF to DSM flight and hotel package with Expedia could lead to significant savings. Better still, having it all in one place will take the stress out of travel planning. Just pick your flights and select from our wide range of hotels, then personalize your trip with extras like car rentals and activities.
Can I cancel or change the date of my flight from Louisville Intl. Airport (SDF) to Des Moines Intl. Airport (DSM)?
If you booked your SDF to DSM flight within the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of fare you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more information.

Explore a world of travel with Expedia

*Available to One Key members.