$177 Cheap Flights from Santiago (SCL) to Medellín (MDE)

View $177 flight on Wed, Dec 3, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Santiago to Medellín (SCL-MDE)

Prices were available within the past 7 days and start at $177 for one-way flights and $319 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Jetsmart SPA
Fri, May 9 - Tue, May 13
SCL
Santiago
MDE
Medellin
$319 Roundtrip, found 3 days ago
$319
Roundtrip
found 3 days ago
Select Jetsmart SPA flight, departing Fri, May 9 from Santiago to Medellin, returning Tue, May 13, priced at $319 found 3 days ago
Jetsmart SPA
Sat, Aug 9 - Sat, Aug 23
SCL
Santiago
MDE
Medellin
$329 Roundtrip, found 2 days ago
$329
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Sat, Aug 9 from Santiago to Medellin, returning Sat, Aug 23, priced at $329 found 2 days ago
Jetsmart SPA
Mon, Aug 11 - Sat, Aug 23
SCL
Santiago
MDE
Medellin
$334 Roundtrip, found 2 days ago
$334
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Mon, Aug 11 from Santiago to Medellin, returning Sat, Aug 23, priced at $334 found 2 days ago
Jetsmart SPA
Tue, Aug 5 - Sat, Aug 23
SCL
Santiago
MDE
Medellin
$339 Roundtrip, found 2 days ago
$339
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Tue, Aug 5 from Santiago to Medellin, returning Sat, Aug 23, priced at $339 found 2 days ago
Jetsmart SPA
Mon, Aug 11 - Fri, Aug 22
SCL
Santiago
MDE
Medellin
$344 Roundtrip, found 2 days ago
$344
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Mon, Aug 11 from Santiago to Medellin, returning Fri, Aug 22, priced at $344 found 2 days ago
Jetsmart SPA
Sat, Aug 16 - Fri, Aug 29
SCL
Santiago
MDE
Medellin
$349 Roundtrip, found 1 day ago
$349
Roundtrip
found 1 day ago
Select Jetsmart SPA flight, departing Sat, Aug 16 from Santiago to Medellin, returning Fri, Aug 29, priced at $349 found 1 day ago
Jetsmart SPA
Mon, Aug 11 - Tue, Aug 26
SCL
Santiago
MDE
Medellin
$354 Roundtrip, found 2 days ago
$354
Roundtrip
found 2 days ago
Select Jetsmart SPA flight, departing Mon, Aug 11 from Santiago to Medellin, returning Tue, Aug 26, priced at $354 found 2 days ago
Copa
Wed, Jun 11 - Mon, Jul 7
SCL
Santiago
MDE
Medellin
$380 Roundtrip, found 3 days ago
$380
Roundtrip
found 3 days ago
Select Copa flight, departing Wed, Jun 11 from Santiago to Medellin, returning Mon, Jul 7, priced at $380 found 3 days ago
avianca
Wed, Jul 16 - Sat, Jul 26
SCL
Santiago
MDE
Medellin
$410 Roundtrip, found 6 days ago
$410
Roundtrip
found 6 days ago
Select avianca flight, departing Wed, Jul 16 from Santiago to Medellin, returning Sat, Jul 26, priced at $410 found 6 days ago
LATAM Airlines Group
Mon, May 26 - Mon, Jun 2
SCL
Santiago
MDE
Medellin
$461 Roundtrip, found 3 hours ago
$461
Roundtrip
found 3 hours ago
Select LATAM Airlines Group flight, departing Mon, May 26 from Santiago to Medellin, returning Mon, Jun 2, priced at $461 found 3 hours ago
Flights from Santiago (SCL) to Medellín (MDE)
Origin airport
Arturo Merino Benitez
Destination airport
José María Córdova Intl.
Airlines serving
Copa, Jetsmart SPA, LATAM Airlines Group, avianca
Roundtrip price
$319
Distance
2750 mi

Santiago to Medellín Flights

The cheapest times to fly from Santiago to Medellín

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Santiago to Medellín are during the month of May. You can find some of the cheapest flights from Santiago to Medellín with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Santiago to Medellín

Sunday is one of the best days to book for cheap flights from Santiago to Medellín: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Santiago to Medellín

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Santiago to Medellín in 2025. You can also book with separate airlines for your outbound and return journeys, from $177 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Santiago to Medellín flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Santiago to Medellín airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE) cost?
Discover the latest flight deals from SCL to MDE by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from SCL to MDE?
The cheapest flights from SCL to MDE are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE)?
Hop on a nonstop flight with AVIANCA and go straight from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE).
What is the cheapest airline that flies from SCL to MDE?
With tickets starting at $210 for a one-way journey from SCL to MDE, Avianca is currently the cheapest airline for this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from SCL on June 9 2025. Prices were last updated on April 27 2025 and have not changed since.
How many flights per day from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE)?
On average, Arturo Merino Benitez Airport (SCL) only has 1 direct flight to Jose Maria Cordova Intl. Airport (MDE) every day. To explore more options, try Expedia’s easy-to-use filter tool. Simply enter your travel details, then click on “1 Stop” or “2+ Stops” to discover flights offering layovers.
What are the most popular departure times for flights from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE)?
More passengers fly between SCL and MDE at 3 AM than at any other time. Prefer a quieter experience? Pick a flight outside the busiest times and it’s possible you’ll save on your ticket as well.
What day of the week has the most flights from SCL to MDE?
Travel on a Monday if you’re after the largest selection of flights from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE).
What is the earliest flight from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE)?
Catch the earliest flight at around 3:05AM UTC-3, heading out of Arturo Merino Benitez Airport (SCL). You’ll be in the air for about 5h 50m, touching down at Jose Maria Cordova Intl. Airport (MDE) at approximately 6:55AM UTC-5.
How long does it take to fly from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE)?
The average flight time from SCL to MDE is 6 hours and 7 minutes, covering a total distance of 2,800 mi.
What airline has the least delays from SCL to MDE?
With 90% of journeys typically landing on time, JetSMART has the best on-time performance for direct flights from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE). To monitor your flight status and get notified if anything changes, simply head to the Expedia App.
What is the best time to fly from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE)?
To land at Jose Maria Cordova Intl. Airport (MDE) without delays, select a flight that leaves from Arturo Merino Benitez Airport (SCL) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Medellin from Arturo Merino Benitez Airport (SCL)?
If you’re flying on a direct flight from Arturo Merino Benitez Airport (SCL) to Medellin, Jose Maria Cordova Intl. Airport (MDE) is the only airport you can touch down at.
Is it cheaper to buy a plane ticket from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE) last-minute?
Waiting until right before your break to book a flight from SCL to MDE often results in higher prices. While it’s possible to find some last-minute deals, they aren’t always guaranteed. Allow some flexibility in your schedule to boost your chances of scoring a bargain.
Is it cheaper to book a SCL to MDE flight and hotel package?
You’ll typically save money by securing a SCL to MDE flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it’s easy to manage it all in one place. Once you’ve selected your preferred accommodations and flights, consider other add-ons like car rentals, activities and tours.
Can I cancel or change the date of my flight from Arturo Merino Benitez Airport (SCL) to Jose Maria Cordova Intl. Airport (MDE)?
It’s generally possible to reschedule or cancel your SCL to MDE flight. However, if the booking was made more than 24 hours ago, additional fees may apply. Check your airline’s policies in your itinerary to see what changes are allowed and if any costs are involved. You’ll also find more details on our Customer Service portal.

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*Available to One Key members.