$144 Cheap Flights from San Diego (SAN) to Greenville (GSP)

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Find available prices by choosing your travel dates.

Cheap Flights from San Diego to Greenville (SAN-GSP)

Prices were available within the past 7 days and start at $144 for one-way flights and $282 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
American Airlines
American Airlines
American Airlines
Southwest Airlines
Delta
Delta
Delta
United
Alaska Airlines
Flights from San Diego (SAN) to Greenville (GSP)
Origin airport
San Diego Intl.
Destination airport
Greenville-Spartanburg Intl.
Airlines serving
Alaska Airlines, American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$282
Distance
2003 mi

San Diego to Greenville Flights

The cheapest times to fly from San Diego to Greenville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from San Diego to Greenville are during the month of May. You can find some of the cheapest flights from San Diego to Greenville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from San Diego to Greenville

Sunday is one of the best days to book for cheap flights from San Diego to Greenville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from San Diego to Greenville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from San Diego to Greenville in 2025. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap San Diego to Greenville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your San Diego to Greenville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

Is it cheaper to buy a plane ticket from San Diego Intl. Airport (SAN) to GSP last minute?
Booking your journey from San Diego Airport to Greenville-Spartanburg Intl. Airport (GSP) last minute could help you save if you hit the jackpot and find an amazing deal. However, tickets generally don’t get cheaper as the date of departure nears. If you take a wait-and-see approach, flights could also be booked solid or the best seats gone (because no one wants the middle seat). If you’d rather not hedge your bets, book well in advance of the date you want to leave. Don’t forget that some of the biggest bargains can be found up to a year in advance. If your favorite airline hasn’t released its airfares yet, check back regularly as deals are constantly updated on Expedia.
What airports do you fly into for Greenville from San Diego?
With Greenville-Spartanburg Intl. Airport (GSP), Asheville Regional Airport (AVL) and Greenville, SC (GMU-Greenville Downtown) to select from, flying from San Diego to Greenville is a snap. The city’s main hub, Greenville-Spartanburg Intl. Airport (GSP), is about 11 mi east of the center. Along with ticket costs, consider things like the ease of getting from the airport and the distance to your hotel when deciding where to fly into. Get your Greenville vacation off to a superb start by visiting Haywood Mall and Furman University.
Can I change the date of my flight from San Diego Intl. Airport (SAN) to Roger Milliken Field?
Life can throw a spanner in your plans, so Expedia is here to help make amending your journey as easy as possible. To start, access your SAN to GSP itinerary through the Expedia Trips portal and read the fare rules and restrictions about what changes are allowed. If you purchased your ticket in the last 24 hours, some airlines will let you cancel for free and book new flights. If you bought your fare more than 24 hours ago, contact us via our Customer Service portal to see how we can assist.

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*Available to One Key members.