$189 Cheap Flights from Panama City (PTY) to Santo Domingo (SDQ)

View $189 flight on Tue, Sep 30, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ)

Find available prices by choosing your travel dates.

Cheap Flights from Panama City to Santo Domingo (PTY-SDQ)

Prices were available within the past 7 days and start at $189 for one-way flights and $336 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Fri, Apr 25 - Tue, Apr 29
PTY
Panama City
SDQ
Santo Domingo
$336 Roundtrip, just found
$336
Roundtrip
just found
Select avianca flight, departing Fri, Apr 25 from Panama City to Santo Domingo, returning Tue, Apr 29, priced at $336 just found
avianca
Wed, Aug 20 - Tue, Aug 26
PTY
Panama City
SDQ
Santo Domingo
$375 Roundtrip, found 15 hours ago
$375
Roundtrip
found 15 hours ago
Select avianca flight, departing Wed, Aug 20 from Panama City to Santo Domingo, returning Tue, Aug 26, priced at $375 found 15 hours ago
avianca
Fri, Apr 25 - Tue, Apr 29
PTY
Panama City
SDQ
Santo Domingo
$412 Roundtrip, just found
$412
Roundtrip
just found
Select avianca flight, departing Fri, Apr 25 from Panama City to Santo Domingo, returning Tue, Apr 29, priced at $412 just found
avianca
Fri, Jul 25 - Wed, Jul 30
PTY
Panama City
SDQ
Santo Domingo
$422 Roundtrip, found 2 hours ago
$422
Roundtrip
found 2 hours ago
Select avianca flight, departing Fri, Jul 25 from Panama City to Santo Domingo, returning Wed, Jul 30, priced at $422 found 2 hours ago
Copa
Thu, Aug 7 - Mon, Aug 11
PTY
Panama City
SDQ
Santo Domingo
$429 Roundtrip, just found
$429
Roundtrip
just found
Select Copa flight, departing Thu, Aug 7 from Panama City to Santo Domingo, returning Mon, Aug 11, priced at $429 just found
avianca
Sun, May 4 - Tue, May 6
PTY
Panama City
SDQ
Santo Domingo
$438 Roundtrip, found 9 hours ago
$438
Roundtrip
found 9 hours ago
Select avianca flight, departing Sun, May 4 from Panama City to Santo Domingo, returning Tue, May 6, priced at $438 found 9 hours ago
Copa
Sun, Apr 27 - Wed, May 28
PTY
Panama City
SDQ
Santo Domingo
$458 Roundtrip, found 15 hours ago
$458
Roundtrip
found 15 hours ago
Select Copa flight, departing Sun, Apr 27 from Panama City to Santo Domingo, returning Wed, May 28, priced at $458 found 15 hours ago
American Airlines
Fri, Jul 11 - Mon, Jul 21
PTY
Panama City
SDQ
Santo Domingo
$511 Roundtrip, just found
$511
Roundtrip
just found
Select American Airlines flight, departing Fri, Jul 11 from Panama City to Santo Domingo, returning Mon, Jul 21, priced at $511 just found
Aeromexico
Fri, Feb 6 - Mon, Feb 16
PTY
Panama City
SDQ
Santo Domingo
$609 Roundtrip, just found
$609
Roundtrip
just found
Select Aeromexico flight, departing Fri, Feb 6 from Panama City to Santo Domingo, returning Mon, Feb 16, priced at $609 just found
United
Fri, Jun 6 - Mon, Jun 9
PTY
Panama City
SDQ
Santo Domingo
$788 Roundtrip, found 4 hours ago
$788
Roundtrip
found 4 hours ago
Select United flight, departing Fri, Jun 6 from Panama City to Santo Domingo, returning Mon, Jun 9, priced at $788 found 4 hours ago
Flights from Panama City (PTY) to Santo Domingo (SDQ)
Origin airport
Tocumen Intl.
Destination airport
Las Americas Intl.
Airlines serving
Aeromexico, American Airlines, Copa, Delta, Iberia, United, avianca
Roundtrip price
$336
Distance
917 mi
Average flight time
3 hours 29 mins

Panama City to Santo Domingo Flights

The cheapest times to fly from Panama City to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Santo Domingo are during the month of April. You can find some of the cheapest flights from Panama City to Santo Domingo with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Panama City to Santo Domingo

Sunday is one of the best days to book for cheap flights from Panama City to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Panama City to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $189 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How long does it take to fly from Tocumen Intl. Airport (PTY) to Santo Domingo Airport?
Book a trip with Copa Airlines and you’ll be traveling for approximately 2 hours and 32 minutes. This well-known airline has a direct flight that sets off at 9:27PM from Panama Airport and gets to SDQ at 12:59AM. Expedia has some amazing flight deals, so find out what’s available on this route today.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to SDQ last minute?
Booking your journey from Tocumen Intl. Airport (PTY) to Las Americas Intl. Airport (SDQ) last minute could save you a nice sum if you get lucky and find a real steal. However, fares don’t usually get cheaper as the departure date nears. If you wait, flights could also be booked solid or the best seats taken (because who wants the middle seat?). If you’d rather not hedge your bets, book well ahead of your departure date. In fact, some of the best deals are available on Expedia up to a year in advance. If your favorite airline hasn’t released tickets yet, check back regularly as offers are constantly updated on Expedia.
What airline has the least delays from PTY to Santo Domingo Airport?
If you don’t want to be stuck at your gate for hours — or worse, have your vacation plans ruined due to a flight delay — opt for Copa Airlines. Around 90% of its PTY to Santo Domingo Airport services touch down on time. You can check your flight status before making your way to the airport through the free Expedia App. It also delivers real-time notifications about other useful things, such as gate number changes and how to reach your hotel. All the details you need are in your pocket with this all-in-one travel companion.
What airports do you fly into for Santo Domingo from Panama City?
Las Americas Intl. Airport (SDQ), La Romana Intl. Airport (LRM) and El Catey Intl. Airport (AZS) are your choices when flying from Panama City to Santo Domingo. Around 15 mi east of the heart of Santo Domingo, Las Americas Intl. Airport (SDQ) is the city’s main hub. Take into account factors like flight arrival and departure times and the distance to your hotel before choosing an airport. Centro Olimpico and Quisqueya Stadium are a couple of top attractions to check out when you arrive at your destination.
What are the most popular departure times for flights from Panama Airport to SDQ?
For Copa Airlines flights jetting from Tocumen Intl. Airport (PTY) to SDQ, the peak period is between 7:00 AM - 8:00 AM. If you’d like to avoid any holdups, book a morning flight. This way you’re likely to miss the air traffic that accumulates as the day goes by.
Can I change the date of my flight from Panama Airport to SDQ?
You can easily make changes to your Panama Airport to SDQ journey through the Expedia Trips portal. But before you make any amendments, read over the conditions in your itinerary to see what the carrier will allow you to do and if change fees apply. Some carriers have a change fee per person, on top of any difference in ticket prices. But if you booked in the last 24 hours, you may be able to cancel for free and arrange new flights. You can also visit our Customer Service portal for more handy information and to chat with our Virtual Agent.

Explore a world of travel with Expedia

*Available to One Key members.