$353 Cheap Flights from Panama City (PTY) to Santiago (SCL)

View $353 flight on Fri, Nov 28, 2025Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Santiago Intl. Airport (SCL)

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Find available prices by choosing your travel dates.

Cheap Flights from Panama City to Santiago (PTY-SCL)

Prices were available within the past 7 days and start at $353 for one-way flights and $579 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Fri, Oct 31 - Fri, Nov 7
PTY
Panama City
SCL
Santiago
$579 Roundtrip, found 12 hours ago
$579
Roundtrip
found 12 hours ago
Select Copa flight, departing Fri, Oct 31 from Panama City to Santiago, returning Fri, Nov 7, priced at $579 found 12 hours ago
Copa
Sun, Aug 31 - Sun, Sep 7
PTY
Panama City
SCL
Santiago
$630 Roundtrip, found 4 hours ago
$630
Roundtrip
found 4 hours ago
Select Copa flight, departing Sun, Aug 31 from Panama City to Santiago, returning Sun, Sep 7, priced at $630 found 4 hours ago
Copa
Fri, May 16 - Mon, May 26
PTY
Panama City
SCL
Santiago
$643 Roundtrip, found 17 hours ago
$643
Roundtrip
found 17 hours ago
Select Copa flight, departing Fri, May 16 from Panama City to Santiago, returning Mon, May 26, priced at $643 found 17 hours ago
avianca
Thu, May 8 - Thu, May 15
PTY
Panama City
SCL
Santiago
$656 Roundtrip, found 2 days ago
$656
Roundtrip
found 2 days ago
Select avianca flight, departing Thu, May 8 from Panama City to Santiago, returning Thu, May 15, priced at $656 found 2 days ago
Copa
Sat, Nov 8 - Sat, Nov 15
PTY
Panama City
SCL
Santiago
$659 Roundtrip, found 1 day ago
$659
Roundtrip
found 1 day ago
Select Copa flight, departing Sat, Nov 8 from Panama City to Santiago, returning Sat, Nov 15, priced at $659 found 1 day ago
Copa
Thu, May 22 - Sun, Jun 1
PTY
Panama City
SCL
Santiago
$662 Roundtrip, found 12 hours ago
$662
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, May 22 from Panama City to Santiago, returning Sun, Jun 1, priced at $662 found 12 hours ago
avianca
Thu, Sep 18 - Mon, Sep 22
PTY
Panama City
SCL
Santiago
$679 Roundtrip, found 1 hour ago
$679
Roundtrip
found 1 hour ago
Select avianca flight, departing Thu, Sep 18 from Panama City to Santiago, returning Mon, Sep 22, priced at $679 found 1 hour ago
Copa
Sun, Aug 31 - Sun, Sep 7
PTY
Panama City
SCL
Santiago
$680 Roundtrip, found 4 hours ago
$680
Roundtrip
found 4 hours ago
Select Copa flight, departing Sun, Aug 31 from Panama City to Santiago, returning Sun, Sep 7, priced at $680 found 4 hours ago
Aeromexico
Sun, Nov 23 - Mon, Dec 1
PTY
Panama City
SCL
Santiago
$989 Roundtrip, found 1 day ago
$989
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Sun, Nov 23 from Panama City to Santiago, returning Mon, Dec 1, priced at $989 found 1 day ago
American Airlines
Sun, Aug 31 - Sun, Sep 7
PTY
Panama City
SCL
Santiago
$1,551 Roundtrip, found 4 hours ago
$1,551
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sun, Aug 31 from Panama City to Santiago, returning Sun, Sep 7, priced at $1,551 found 4 hours ago

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) cost?
Cheap round-trip flights from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) start at $630. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving PTY on May 16 2025 and touching down at SCL. The price was last updated on April 24 2025 and has not changed since.
What is the cheapest month to fly from PTY to SCL?
The cheapest flights from PTY to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
If you’re departing from Tocumen Intl. Airport (PTY), you can board a direct flight to Arturo Merino Benitez Airport (SCL) with Copa Airlines.
What is the cheapest airline that flies from PTY to SCL?
Journey from PTY to SCL with Copa. This carrier currently offers the lowest one-way fare for this route, starting from $1077. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from PTY on May 27 2025. Prices were last updated on April 24 2025 and have not changed since.
How many flights per day from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
When taking off from Tocumen Intl. Airport (PTY), you can pick from an average of 5 daily nonstop flights to Arturo Merino Benitez Airport (SCL).
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Flights between PTY and SCL are their busiest at 3 PM. For a quieter experience and possibly cheaper tickets, choose a departure that’s outside typical rush times.
What day of the week has the most flights from PTY to SCL?
Friday offers the most flights from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL). Consider jetting off on this day and you’ll have a greater chance of finding a departure that fits your plans.
What is the earliest flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Catch the earliest flight at around 11:47AM UTC-5, leaving from Tocumen Intl. Airport (PTY). You’ll be flying for around 6h 32m, landing at Arturo Merino Benitez Airport (SCL) at approximately 8:19PM UTC-3.
How long does it take to fly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
The average flight time from PTY to SCL is 6 hours and 35 minutes, covering a total distance of 3,000 mi.
What airline has the least delays from PTY to SCL?
Consider traveling with American Airlines if you’d like to go straight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) without any delays. This airline has the best track record for punctuality, with an on-time score of 100%. Want real-time updates? You can check your flight status using the Expedia App.
What is the best time to fly from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Opt for a flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Santiago from Tocumen Intl. Airport (PTY)?
Arturo Merino Benitez Airport (SCL) is the only airport in Santiago with direct flights from Tocumen Intl. Airport (PTY). Consider the options and discover cheap fares on Expedia.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL) last-minute?
Last-minute fares from PTY to SCL are generally more expensive. To secure the lowest rates, start looking for flights as early as possible. That said, if you can play around with your travel dates, you may land a cheap fare right before your trip.
Is it cheaper to book a PTY to SCL flight and hotel package?
Compared with arranging flights and hotels separately, booking a PTY to SCL flight and hotel package with Expedia could lead to significant savings. Better yet, having it all in one place takes the hassle out of travel planning. Simply secure your flights and select from our wide range of stays, then customize your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to Arturo Merino Benitez Airport (SCL)?
Typically, you’re able to cancel or reschedule your PTY to SCL flight. However, there may be additional fees, especially if your booking was made over 24 hours ago. Double-check your itinerary for the airline’s fees and guidelines on flight changes, or if you need further details, visit our Customer Service portal.
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