$316 Cheap Flights from Panama City (PTY) to Chicago (ORD)

View $316 flight on Tue, Apr 21, 2026Opens in a new window

Popular airlines from Tocumen Intl. Airport (PTY) to Chicago O'Hare Intl. Airport (ORD)

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Cheap Flights from Panama City to Chicago (PTY-ORD)

Prices were available within the past 7 days and start at $316 for one-way flights and $580 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, Apr 1 - Mon, Apr 6
PTY
Panama City
ORD
Chicago
$580 Roundtrip, just found
$580
Roundtrip
just found
Select Copa flight, departing Wed, Apr 1 from Panama City to Chicago, returning Mon, Apr 6, priced at $580 just found
Copa
Fri, Feb 20 - Thu, Mar 12
PTY
Panama City
ORD
Chicago
$582 Roundtrip, found 3 hours ago
$582
Roundtrip
found 3 hours ago
Select Copa flight, departing Fri, Feb 20 from Panama City to Chicago, returning Thu, Mar 12, priced at $582 found 3 hours ago
Aeromexico
Wed, Feb 18 - Sat, Feb 28
PTY
Panama City
ORD
Chicago
$588 Roundtrip, found 5 hours ago
$588
Roundtrip
found 5 hours ago
Select Aeromexico flight, departing Wed, Feb 18 from Panama City to Chicago, returning Sat, Feb 28, priced at $588 found 5 hours ago
American Airlines
Thu, Apr 23 - Tue, Apr 28
PTY
Panama City
ORD
Chicago
$594 Roundtrip, found 6 hours ago
$594
Roundtrip
found 6 hours ago
Select American Airlines flight, departing Thu, Apr 23 from Panama City to Chicago, returning Tue, Apr 28, priced at $594 found 6 hours ago
United
Wed, Apr 1 - Mon, Apr 6
PTY
Panama City
ORD
Chicago
$594 Roundtrip, just found
$594
Roundtrip
just found
Select United flight, departing Wed, Apr 1 from Panama City to Chicago, returning Mon, Apr 6, priced at $594 just found
Aeromexico
Thu, Feb 5 - Mon, Feb 9
PTY
Panama City
ORD
Chicago
$595 Roundtrip, found 1 day ago
$595
Roundtrip
found 1 day ago
Select Aeromexico flight, departing Thu, Feb 5 from Panama City to Chicago, returning Mon, Feb 9, priced at $595 found 1 day ago
United
Fri, Feb 20 - Thu, Mar 12
PTY
Panama City
ORD
Chicago
$596 Roundtrip, found 3 hours ago
$596
Roundtrip
found 3 hours ago
Select United flight, departing Fri, Feb 20 from Panama City to Chicago, returning Thu, Mar 12, priced at $596 found 3 hours ago
Copa
Fri, Feb 20 - Thu, Mar 12
PTY
Panama City
ORD
Chicago
$598 Roundtrip, found 3 hours ago
$598
Roundtrip
found 3 hours ago
Select Copa flight, departing Fri, Feb 20 from Panama City to Chicago, returning Thu, Mar 12, priced at $598 found 3 hours ago
American Airlines
Mon, Apr 27 - Thu, Apr 30
PTY
Panama City
ORD
Chicago
$599 Roundtrip, found 1 day ago
$599
Roundtrip
found 1 day ago
Select American Airlines flight, departing Mon, Apr 27 from Panama City to Chicago, returning Thu, Apr 30, priced at $599 found 1 day ago
avianca
Fri, Feb 20 - Thu, Mar 12
PTY
Panama City
ORD
Chicago
$621 Roundtrip, found 3 hours ago
$621
Roundtrip
found 3 hours ago
Select avianca flight, departing Fri, Feb 20 from Panama City to Chicago, returning Thu, Mar 12, priced at $621 found 3 hours ago

Find the cheapest month to fly from Panama City (PTY) to Chicago (ORD)

October is typically the cheapest month to fly

From $396 - $719 per traveler.

Alternative airports near Chicago

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to O'Hare Intl. ORD. Cheapest option available. Average driving time to city center is 23 minutes. Flights from $694
ORD
O'Hare Intl.
Cheapest
Average driving time to city center23 min
Flights from $694
Flights from Panama City (PTY) to Chicago (ORD)
Origin airport
Tocumen Intl.
Destination airport
O'Hare Intl.
Airlines serving
Aeromexico, American Airlines, Copa, Delta, United, avianca
Roundtrip price
$579
Distance
2332 mi
Average flight time
4 hours 48 mins

Panama City to Chicago Flights

The cheapest times to fly from Panama City to Chicago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Panama City to Chicago are during the month of April. You can find some of the cheapest flights from Panama City to Chicago with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Panama City to Chicago

Sunday is one of the best days to book for cheap flights from Panama City to Chicago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Panama City to Chicago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Panama City to Chicago in 2026. You can also book with separate airlines for your outbound and return journeys, from $316 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Panama City to Chicago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Panama City to Chicago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD) cost?
Lock in a cheap one-way flight from $316 or cheap return flight from $580 from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
Planning your trip for April can help you save, as it's the cheapest month for flights between PTY and ORD. You'll usually find the lowest prices during the off-season.
Which airlines fly direct from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
Hop on a direct flight with Copa Airlines and journey straight from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD).
What is the cheapest airline that flies from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
To find the cheapest airline flying from PTY to ORD, use Expedia's filter tool. Customize your search based on what matters most to you, such as preferred carriers and ideal departure window. You can then sort your results by "Price (lowest to highest)" to list the most affordable options first.
How many flights per day from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
On average, there is just 1 direct flight operating from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD) per day. If this isn't convenient for you, check out flights with layovers. Just customize your search results on Expedia to include one or two stops to find the next best option.
What are the most popular departure times for flights from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
More travelers fly between PTY and ORD at 6 PM than at any other time. Rather go when it's quieter? Travel outside of rush hours and it's possible you'll save on your ticket as well.
What day of the week has the most flights from PTY to ORD?
Fly on a Friday if you're after the largest selection of flights from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD).
What is the earliest flight from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
Tocumen Intl. Airport (PTY)'s earliest flight to O'Hare Intl. Airport (ORD) is at approximately 6:45PM UTC-5. With a total travel time of 5h 42m, you'll arrive at around 11:27PM UTC-6.
How long does it take to fly from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
The average flight time from PTY to ORD is 5 hours and 42 minutes, covering a total distance of 2,300 mi.
What airline has the least delays from PTY to ORD?
United Airlines has the best track record for on-time direct flights from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD), with an on-time score of 93%. Use the Expedia App to view your flight schedule before you head off and get immediate updates about any changes.
What is the best time to fly from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
Choose a flight from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
What airports do you fly into for Chicago from Tocumen Intl. Airport (PTY)?
If you're on a direct flight from Tocumen Intl. Airport (PTY) to Chicago, O'Hare Intl. Airport (ORD) is the only airport you can touch down at.
Is it cheaper to buy a plane ticket from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD) last-minute?
Last-minute bookings from PTY to ORD are typically more expensive. For the cheapest rates, start searching for flights early. That being said, if you can play around with your travel dates, it's possible to land a cheap fare right before your trip.
Is it cheaper to book a PTY to ORD flight and hotel package?
Compared with arranging hotels and flights separately, booking a PTY to ORD flight and hotel package with Expedia could lead to significant savings. Better still, managing everything in one place will take the hassle out of travel planning. Simply pick your flights and choose from our extensive range of stays, then customize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Tocumen Intl. Airport (PTY) to O'Hare Intl. Airport (ORD)?
If you reserved your PTY to ORD flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal if you want more information.

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*Available to One Key members.