
Popular airlines from Chicago O'Hare Intl. Airport (ORD) to Santiago del Estero (SDE-Vicecomodoro Angel de la Paz Aragones)
- American Airlines
American Airlines
- United
United
- Southwest Airlines
Southwest Airlines
- Delta
Delta
- Frontier Airlines
Frontier Airlines
- JetBlue Airways
JetBlue Airways
- Alaska Airlines
Alaska Airlines
- Plan, book, fly with confidence
- Be in the knowGet alerts if flight prices drop or rise*
- Book smarterSave up to 30% on select hotels after you book a flight*
Origin airport | O'Hare Intl. |
Destination airport | Vicecomodoro Angel de la Paz Aragones |
Distance | 5047 mi |
Chicago to Santiago del Estero Flights
The cheapest times to fly from Chicago to Santiago del Estero
On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Santiago del Estero are during the month of . You can find some of the cheapest flights from Chicago to Santiago del Estero with Expedia's search tool and vast selection of airlines.
The best time to book a flight from Chicago to Santiago del Estero
Sunday is one of the best days to book for cheap flights from Chicago to Santiago del Estero: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.
How to find cheap round-trip tickets from Chicago to Santiago del Estero
Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Santiago del Estero in 2025. You can also book with separate airlines for your outbound and return journeys, from one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.
Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Santiago del Estero flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.
You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Santiago del Estero airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.
*Terms apply.
Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.
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Lodging
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Packages
- Casa de Gobierno
- Visit Santiago del Estero
- Santiago del Estero Vacations
- Bicentenario Cultural Center
- Visit Santiago del Estero Province
- Santiago del Estero Cathedral
- Plaza Libertad
- Santiago del Estero Province Vacations
- Aguirre Park
- Visit La Banda
- La Banda Vacations
- Plaza Sarmiento
- Brisas Spa
- La Merced Convent
- Forum Convention Center
Cars
- Hertz Rental Cars in Santiago del Estero
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- Fox Rental Cars Rental Cars in Santiago del Estero Province
- Premium Car Rentals in Santiago del Estero
- Car rentals near Teatro 25 de Mayo
- Car rentals near Forum Convention Center
- Car rentals near La Merced Convent
- Car rentals near Forres