$164 Cheap Flights from Chicago (ORD) to Panama City (PTY)

View $164 flight on Sun, Jun 29, 2025Opens in a new window

Popular airlines from Chicago O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY)

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Find available prices by choosing your travel dates.

Cheap Flights from Chicago to Panama City (ORD-PTY)

Prices were available within the past 7 days and start at $164 for one-way flights and $446 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Wed, Jun 25 - Wed, Jul 2
ORD
Chicago
PTY
Panama City
$446 Roundtrip, just found
$446
Roundtrip
just found
Select avianca flight, departing Wed, Jun 25 from Chicago to Panama City, returning Wed, Jul 2, priced at $446 just found
avianca
Wed, Jun 25 - Wed, Jul 2
ORD
Chicago
PTY
Panama City
$464 Roundtrip, just found
$464
Roundtrip
just found
Select avianca flight, departing Wed, Jun 25 from Chicago to Panama City, returning Wed, Jul 2, priced at $464 just found
Copa
Fri, May 16 - Tue, May 20
ORD
Chicago
PTY
Panama City
$465 Roundtrip, found 1 hour ago
$465
Roundtrip
found 1 hour ago
Select Copa flight, departing Fri, May 16 from Chicago to Panama City, returning Tue, May 20, priced at $465 found 1 hour ago
avianca
Fri, Jan 16 - Sat, Jan 24
ORD
Chicago
PTY
Panama City
$477 Roundtrip, just found
$477
Roundtrip
just found
Select avianca flight, departing Fri, Jan 16 from Chicago to Panama City, returning Sat, Jan 24, priced at $477 just found
Delta
Thu, May 29 - Wed, Jun 4
ORD
Chicago
PTY
Panama City
$479 Roundtrip, just found
$479
Roundtrip
just found
Select Delta flight, departing Thu, May 29 from Chicago to Panama City, returning Wed, Jun 4, priced at $479 just found
United
Thu, Jul 10 - Wed, Jul 16
ORD
Chicago
PTY
Panama City
$479 Roundtrip, just found
$479
Roundtrip
just found
Select United flight, departing Thu, Jul 10 from Chicago to Panama City, returning Wed, Jul 16, priced at $479 just found
Delta
Thu, Jul 10 - Wed, Jul 16
ORD
Chicago
PTY
Panama City
$484 Roundtrip, just found
$484
Roundtrip
just found
Select Delta flight, departing Thu, Jul 10 from Chicago to Panama City, returning Wed, Jul 16, priced at $484 just found
United
Thu, May 29 - Wed, Jun 4
ORD
Chicago
PTY
Panama City
$488 Roundtrip, just found
$488
Roundtrip
just found
Select United flight, departing Thu, May 29 from Chicago to Panama City, returning Wed, Jun 4, priced at $488 just found
United
Thu, Jul 10 - Wed, Jul 16
ORD
Chicago
PTY
Panama City
$489 Roundtrip, just found
$489
Roundtrip
just found
Select United flight, departing Thu, Jul 10 from Chicago to Panama City, returning Wed, Jul 16, priced at $489 just found
American Airlines
Thu, Jul 10 - Wed, Jul 16
ORD
Chicago
PTY
Panama City
$563 Roundtrip, just found
$563
Roundtrip
just found
Select American Airlines flight, departing Thu, Jul 10 from Chicago to Panama City, returning Wed, Jul 16, priced at $563 just found
Flights from Chicago (ORD) to Panama City (PTY)
Origin airport
O'Hare Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United, avianca
Roundtrip price
$445
Distance
2332 mi

Chicago to Panama City Flights

The cheapest times to fly from Chicago to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Chicago to Panama City are during the month of June. You can find some of the cheapest flights from Chicago to Panama City with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Chicago to Panama City

Sunday is one of the best days to book for cheap flights from Chicago to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Chicago to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Chicago to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $164 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Chicago to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Chicago to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY) cost?
Grab cheap return fares starting at $597 from O’Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Copa flight leaving ORD on May 19 2025 and touching down at PTY. The price was last updated on April 22 2025 and has not changed since.
What is the cheapest month to fly from ORD to PTY?
The cheapest flights from ORD to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY)?
If you’re departing from O’Hare Intl. Airport (ORD), you can jump on a nonstop flight to Tocumen Intl. Airport (PTY) with Copa Airlines.
What is the cheapest airline that flies from ORD to PTY?
With tickets starting at $838 for a one-way journey from ORD to PTY, Copa is currently the cheapest carrier operating this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from ORD on July 1 2025. Prices were last updated on April 22 2025 and have not changed since.
How many flights per day from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY)?
On average, there’s only 1 nonstop flight leaving from O’Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY) every day. If this isn’t convenient for you, check out flights with a layover. Just customize your search results on Expedia to include one stop or more to discover the next best option.
What are the most popular departure times for flights from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY)?
Flights between ORD and PTY are busiest at 6 AM. If you’d like a quieter experience and possibly cheaper prices, choose a time outside the usual busy windows.
What day of the week has the most flights from ORD to PTY?
If you depart on a Sunday, you’ll get the largest range of options for flights from O’Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY).
What is the earliest flight from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY)?
O’Hare Intl. Airport (ORD)’s earliest flight to Tocumen Intl. Airport (PTY) takes off at approximately 6:55AM UTC-6. With a travel duration of 5h 27m, you’ll land at around 1:22PM UTC-5.
How long does it take to fly from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY)?
It takes around 5 hours and 27 minutes to cover the 2,300 mi from ORD to PTY.
What airline has the least delays from ORD to PTY?
Copa Airlines has the best performance for on-time direct flights from O’Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY), with an on-time score of 92%. Use the Expedia App to check your journey status before you jet off and receive notifications about any trip changes.
What is the best time to fly from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY)?
To avoid possible delays on the O’Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY) route, fly before 3 PM. Later flights have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Panama City from O'Hare Intl. Airport (ORD)?
If you’re traveling on a direct flight from O’Hare Intl. Airport (ORD) to Panama City, Tocumen Intl. Airport (PTY) is the only airport you can land at.
Is it cheaper to buy a plane ticket from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY) last-minute?
Waiting until just before your departure to book your flight from ORD to PTY often results in higher prices. While it’s possible to find some last-minute offers, there’s no guarantee. Be flexible with your itinerary to boost your chances of snagging a bargain.
Is it cheaper to book an ORD to PTY flight and hotel package?
Compared with arranging hotels and flights separately, booking an ORD to PTY flight and hotel package with Expedia could result in significant savings. What’s more, managing everything in one place takes the hassle out of travel planning. Simply secure your flights and choose from our wide range of stays, then customize your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from O'Hare Intl. Airport (ORD) to Tocumen Intl. Airport (PTY)?
If you reserved your ORD to PTY flight in the last 24 hours, you may be able to cancel or modify it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more information.

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*Available to One Key members.