$129 Cheap Flights from Myrtle Beach (MYR) to Buffalo (BUF)

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Cheap Flights from Myrtle Beach to Buffalo (MYR-BUF)

Prices were available within the past 7 days and start at $129 for one-way flights and $257 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
United
American Airlines
American Airlines
Delta
Southwest Airlines
Delta
Southwest Airlines
Southwest Airlines
United
Flights from Myrtle Beach (MYR) to Buffalo (BUF)
Origin airport
Myrtle Beach Intl.
Destination airport
Buffalo Niagara Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$256
Distance
639 mi

Myrtle Beach to Buffalo Flights

The cheapest times to fly from Myrtle Beach to Buffalo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Myrtle Beach to Buffalo are during the month of July. You can find some of the cheapest flights from Myrtle Beach to Buffalo with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Myrtle Beach to Buffalo

Sunday is one of the best days to book for cheap flights from Myrtle Beach to Buffalo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Myrtle Beach to Buffalo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Myrtle Beach to Buffalo in 2025. You can also book with separate airlines for your outbound and return journeys, from $129 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Myrtle Beach to Buffalo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Myrtle Beach to Buffalo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

Is it cheaper to buy a plane ticket from Myrtle Beach Intl. Airport (MYR) to BUF last minute?
When it’s time to book your flights, being prepared pays off. While it’s possible to score a last-minute deal on a Myrtle Beach Intl. Airport (MYR) to Buffalo Niagara Intl. Airport (BUF) flight, tickets usually don’t get cheaper as the date of departure nears. Based on flight pricing and demand studies in 2022, we have found that the sweet spot to book a domestic flight is between 28 – 35 days in advance. For international flights it’s between three and four months.
What airports do you fly into for Buffalo from Myrtle Beach?
From Myrtle Beach, you can connect to Buffalo via Buffalo Niagara Intl. Airport (BUF), Billy Bishop Toronto City Airport (YTZ) and Chautauqua County Airport (JHW). It’s wise to check which hub is more convenient for you before you make a decision. If you choose Buffalo Niagara Intl. Airport (BUF), it’s about 8 mi northeast of the downtown area. Use the money you save when booking your airfare with Expedia to enjoy the city’s well-known sights, such as KeyBank Center and Buffalo and Erie County Naval and Military Park.
Can I change the date of my flight from MYR to BUF?
It’s a piece of cake to make amendments to your Myrtle Beach Intl. Airport to BUF journey yourself. Simply log in to the Expedia Trips portal and select “change flight.” Look for new flights and book the one that better fits your plans. You’ll get an estimate of any flight change costs. Alternatively, use our Customer Service portal to connect with our Virtual Agent and quickly get answers to your questions.

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*Available to One Key members.