$450 Cheap Flights from New Orleans (MSY) to Santiago (SCL)

View $450 flight on Mon, Mar 2, 2026Opens in a new window

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key
Find available prices by choosing your travel dates.

Cheap Flights from New Orleans to Santiago (MSY-SCL)

Prices were available within the past 7 days and start at $450 for one-way flights and $704 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Mon, Oct 13 - Mon, Oct 20
MSY
New Orleans
SCL
Santiago
$704 Roundtrip, found 2 hours ago
$704
Roundtrip
found 2 hours ago
Select Delta flight, departing Mon, Oct 13 from New Orleans to Santiago, returning Mon, Oct 20, priced at $704 found 2 hours ago
American Airlines
Thu, Aug 28 - Tue, Sep 9
MSY
New Orleans
SCL
Santiago
$708 Roundtrip, found 1 day ago
$708
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 28 from New Orleans to Santiago, returning Tue, Sep 9, priced at $708 found 1 day ago
Delta
Thu, Aug 28 - Tue, Sep 9
MSY
New Orleans
SCL
Santiago
$711 Roundtrip, found 1 day ago
$711
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Aug 28 from New Orleans to Santiago, returning Tue, Sep 9, priced at $711 found 1 day ago
American Airlines
Thu, Aug 28 - Tue, Sep 9
MSY
New Orleans
SCL
Santiago
$717 Roundtrip, found 1 day ago
$717
Roundtrip
found 1 day ago
Select American Airlines flight, departing Thu, Aug 28 from New Orleans to Santiago, returning Tue, Sep 9, priced at $717 found 1 day ago
Delta
Thu, Aug 28 - Tue, Sep 9
MSY
New Orleans
SCL
Santiago
$724 Roundtrip, found 1 day ago
$724
Roundtrip
found 1 day ago
Select Delta flight, departing Thu, Aug 28 from New Orleans to Santiago, returning Tue, Sep 9, priced at $724 found 1 day ago
Delta
Sat, Oct 11 - Mon, Oct 20
MSY
New Orleans
SCL
Santiago
$744 Roundtrip, found 2 hours ago
$744
Roundtrip
found 2 hours ago
Select Delta flight, departing Sat, Oct 11 from New Orleans to Santiago, returning Mon, Oct 20, priced at $744 found 2 hours ago
Delta
Sun, Oct 12 - Mon, Oct 20
MSY
New Orleans
SCL
Santiago
$748 Roundtrip, found 2 hours ago
$748
Roundtrip
found 2 hours ago
Select Delta flight, departing Sun, Oct 12 from New Orleans to Santiago, returning Mon, Oct 20, priced at $748 found 2 hours ago
LATAM Airlines Group
Wed, Sep 3 - Wed, Sep 10
MSY
New Orleans
SCL
Santiago
$769 Roundtrip, found 1 day ago
$769
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Wed, Sep 3 from New Orleans to Santiago, returning Wed, Sep 10, priced at $769 found 1 day ago
United
Mon, Dec 1 - Sun, Dec 14
MSY
New Orleans
SCL
Santiago
$941 Roundtrip, found 1 day ago
$941
Roundtrip
found 1 day ago
Select United flight, departing Mon, Dec 1 from New Orleans to Santiago, returning Sun, Dec 14, priced at $941 found 1 day ago
Air Canada
Wed, Dec 24 - Tue, Jan 6
MSY
New Orleans
SCL
Santiago
$1,437 Roundtrip, found 2 days ago
$1,437
Roundtrip
found 2 days ago
Select Air Canada flight, departing Wed, Dec 24 from New Orleans to Santiago, returning Tue, Jan 6, priced at $1,437 found 2 days ago
Flights from New Orleans (MSY) to Santiago (SCL)
Origin airport
Louis Armstrong New Orleans Intl.
Destination airport
Arturo Merino Benitez
Airlines serving
Air Canada, American Airlines, Delta, LATAM Airlines Group
Roundtrip price
$703
Distance
4560 mi

New Orleans to Santiago Flights

The cheapest times to fly from New Orleans to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from New Orleans to Santiago are during the month of October. You can find some of the cheapest flights from New Orleans to Santiago with Expedia's search tool and vast selection of airlines.

The best time to book a flight from New Orleans to Santiago

Sunday is one of the best days to book for cheap flights from New Orleans to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from New Orleans to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from New Orleans to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $450 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap New Orleans to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your New Orleans to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Louis Armstrong New Orleans Intl. Airport (MSY) to Arturo Merino Benitez Airport (SCL) cost?
Discover the latest flight deals from MSY to SCL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MSY to SCL?
The cheapest flights from MSY to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MSY to SCL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from MSY to SCL. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Louis Armstrong New Orleans Intl. Airport (MSY) to Arturo Merino Benitez Airport (SCL)?
You’ll have to catch a flight with a layover if you’re traveling from Louis Armstrong New Orleans Intl. Airport (MSY) to Arturo Merino Benitez Airport (SCL). Direct flights don’t operate daily on this route. However, just filter your search to include one or more stops to discover an option that works for you.
What day of the week has the most flights from MSY to SCL?
You’ll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during public holidays or peak travel times.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Louis Armstrong New Orleans Intl. Airport (MSY) to Arturo Merino Benitez Airport (SCL)?
Select a flight from Louis Armstrong New Orleans Intl. Airport (MSY) to Arturo Merino Benitez Airport (SCL) that leaves before 3 PM to reduce the risk of cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Louis Armstrong New Orleans Intl. Airport (MSY) to Arturo Merino Benitez Airport (SCL) last-minute?
Last-minute fares from MSY to SCL are typically more expensive. To secure the cheapest rates, start looking for flights as soon as possible. That being said, if your travel plans are flexible, you may land a cheap ticket right before your journey.
Is it cheaper to book a MSY to SCL flight and hotel package?
Booking a MSY to SCL flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our wide range of accommodations and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Louis Armstrong New Orleans Intl. Airport (MSY) to Arturo Merino Benitez Airport (SCL)?
Typically, you can cancel or modify your MSY to SCL flight. However, there may be additional fees, especially if you made your booking more than 24 hours ago. Double-check your itinerary for the airline’s policies and fees on flight changes, or if you want further details, go to our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.