$100 Cheap Flights from Madison (MSN) to Des Moines (DSM)

View $100 flight on Sun, May 25, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Madison to Des Moines (MSN-DSM)

Prices were available within the past 7 days and start at $100 for one-way flights and $209 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, May 21 - Sun, May 25
MSN
Madison
DSM
Des Moines
$209 Roundtrip, found 1 day ago
$209
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, May 21 from Madison to Des Moines, returning Sun, May 25, priced at $209 found 1 day ago
Frontier Airlines
Sun, Apr 27 - Wed, Apr 30
MSN
Madison
DSM
Des Moines
$211 Roundtrip, found 1 day ago
$211
Roundtrip
found 1 day ago
Select Frontier Airlines flight, departing Sun, Apr 27 from Madison to Des Moines, returning Wed, Apr 30, priced at $211 found 1 day ago
Delta
Tue, Jul 1 - Tue, Jul 29
MSN
Madison
DSM
Des Moines
$218 Roundtrip, found 3 days ago
$218
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Jul 1 from Madison to Des Moines, returning Tue, Jul 29, priced at $218 found 3 days ago
Frontier Airlines
Sun, May 4 - Wed, May 7
MSN
Madison
DSM
Des Moines
$218 Roundtrip, found 18 hours ago
$218
Roundtrip
found 18 hours ago
Select Frontier Airlines flight, departing Sun, May 4 from Madison to Des Moines, returning Wed, May 7, priced at $218 found 18 hours ago
American Airlines
Fri, Jun 6 - Mon, Jun 9
MSN
Madison
DSM
Des Moines
$219 Roundtrip, found 1 hour ago
$219
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Fri, Jun 6 from Madison to Des Moines, returning Mon, Jun 9, priced at $219 found 1 hour ago
United
Sat, Oct 18 - Sun, Oct 19
MSN
Madison
DSM
Des Moines
$219 Roundtrip, found 1 day ago
$219
Roundtrip
found 1 day ago
Select United flight, departing Sat, Oct 18 from Madison to Des Moines, returning Sun, Oct 19, priced at $219 found 1 day ago
Frontier Airlines
Sun, May 4 - Wed, May 21
MSN
Madison
DSM
Des Moines
$220 Roundtrip, found 2 hours ago
$220
Roundtrip
found 2 hours ago
Select Frontier Airlines flight, departing Sun, May 4 from Madison to Des Moines, returning Wed, May 21, priced at $220 found 2 hours ago
Delta
Mon, May 5 - Wed, May 21
MSN
Madison
DSM
Des Moines
$229 Roundtrip, found 2 hours ago
$229
Roundtrip
found 2 hours ago
Select Delta flight, departing Mon, May 5 from Madison to Des Moines, returning Wed, May 21, priced at $229 found 2 hours ago
United
Sat, Oct 18 - Sun, Oct 19
MSN
Madison
DSM
Des Moines
$230 Roundtrip, found 1 day ago
$230
Roundtrip
found 1 day ago
Select United flight, departing Sat, Oct 18 from Madison to Des Moines, returning Sun, Oct 19, priced at $230 found 1 day ago
Frontier Airlines
Sun, Apr 27 - Wed, Apr 30
MSN
Madison
DSM
Des Moines
$231 Roundtrip, found 2 days ago
$231
Roundtrip
found 2 days ago
Select Frontier Airlines flight, departing Sun, Apr 27 from Madison to Des Moines, returning Wed, Apr 30, priced at $231 found 2 days ago
Flights from Madison (MSN) to Des Moines (DSM)
Origin airport
Dane County Regional
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Frontier Airlines, United
Roundtrip price
$208
Distance
246 mi

Madison to Des Moines Flights

The cheapest times to fly from Madison to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Madison to Des Moines are during the month of May. You can find some of the cheapest flights from Madison to Des Moines with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Madison to Des Moines

Sunday is one of the best days to book for cheap flights from Madison to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Madison to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Madison to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $100 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Madison to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Madison to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Dane County Regional Airport (MSN) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from MSN to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MSN to DSM?
The cheapest flights from MSN to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MSN to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from MSN to DSM. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Dane County Regional Airport (MSN) to Des Moines Intl. Airport (DSM)?
You’ll have to book a flight with a layover if you’re traveling from Dane County Regional Airport (MSN) to Des Moines Intl. Airport (DSM). There are no daily direct flights on this route. However, just filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from MSN to DSM?
You’ll generally find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Dane County Regional Airport (MSN) to Des Moines Intl. Airport (DSM)?
To arrive at Des Moines Intl. Airport (DSM) without delays, select a flight that leaves Dane County Regional Airport (MSN) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Dane County Regional Airport (MSN) to Des Moines Intl. Airport (DSM) last-minute?
Waiting until right before your break to book your flight from MSN to DSM generally means paying more. Although you may find some last-minute discounts, they’re not always guaranteed. Allow some flexibility in your schedule to boost your chances of snagging a bargain.
Is it cheaper to book a MSN to DSM flight and hotel package?
Compared with arranging flights and hotels separately, booking a MSN to DSM flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one easy place takes the hassle out of planning your trip. Just pick your flights and choose from our extensive range of stays, then customize your trip with other add-ons like car rentals and activities.
Can I cancel or change the date of my flight from Dane County Regional Airport (MSN) to Des Moines Intl. Airport (DSM)?
If you booked your MSN to DSM flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you’d like more information.

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*Available to One Key members.