$230 Cheap Flights from Monroe (MLU) to Knoxville (TYS)

View $230 flight on Thu, Jan 15, 2026Opens in a new window

Popular airlines from Monroe, LA (MLU-Monroe Regional) to McGhee Tyson Airport (TYS)

  • notification illustration

    Be in the know

    Get alerts if flight prices drop or rise*
  • deals illustration

    Book smarter

    Save up to 30% on select hotels after you book a flight*
  • trophy illustration

    Earn twice

    Earn your airline miles on top of our OneKeyCash
    Learn about One Key

Cheap Flights from Monroe to Knoxville (MLU-TYS)

Prices were available within the past 7 days and start at $230 for one-way flights and $258 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Feb 17 - Sun, Mar 1
MLU
Monroe
TYS
Knoxville
$258 Roundtrip, found 4 days ago
$258
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 17 from Monroe to Knoxville, returning Sun, Mar 1, priced at $258 found 4 days ago
Delta
Wed, Jan 28 - Tue, Feb 3
MLU
Monroe
TYS
Knoxville
$273 Roundtrip, found 6 days ago
$273
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Jan 28 from Monroe to Knoxville, returning Tue, Feb 3, priced at $273 found 6 days ago
American Airlines
Mon, Feb 2 - Sun, Feb 8
MLU
Monroe
TYS
Knoxville
$278 Roundtrip, found 10 hours ago
$278
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Mon, Feb 2 from Monroe to Knoxville, returning Sun, Feb 8, priced at $278 found 10 hours ago
Delta
Tue, Feb 17 - Tue, Mar 3
MLU
Monroe
TYS
Knoxville
$303 Roundtrip, found 4 days ago
$303
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 17 from Monroe to Knoxville, returning Tue, Mar 3, priced at $303 found 4 days ago
Delta
Wed, Feb 11 - Wed, Feb 18
MLU
Monroe
TYS
Knoxville
$313 Roundtrip, found 1 day ago
$313
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, Feb 11 from Monroe to Knoxville, returning Wed, Feb 18, priced at $313 found 1 day ago
American Airlines
Sat, Feb 21 - Thu, Mar 5
MLU
Monroe
TYS
Knoxville
$328 Roundtrip, found 4 days ago
$328
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Feb 21 from Monroe to Knoxville, returning Thu, Mar 5, priced at $328 found 4 days ago
Delta
Tue, Feb 17 - Mon, Mar 2
MLU
Monroe
TYS
Knoxville
$333 Roundtrip, found 4 days ago
$333
Roundtrip
found 4 days ago
Select Delta flight, departing Tue, Feb 17 from Monroe to Knoxville, returning Mon, Mar 2, priced at $333 found 4 days ago
American Airlines
Fri, Oct 30 - Sun, Nov 1
MLU
Monroe
TYS
Knoxville
$338 Roundtrip, found 3 days ago
$338
Roundtrip
found 3 days ago
Select American Airlines flight, departing Fri, Oct 30 from Monroe to Knoxville, returning Sun, Nov 1, priced at $338 found 3 days ago
American Airlines
Sat, Feb 21 - Sun, Feb 22
MLU
Monroe
TYS
Knoxville
$343 Roundtrip, found 4 days ago
$343
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Feb 21 from Monroe to Knoxville, returning Sun, Feb 22, priced at $343 found 4 days ago
American Airlines
Mon, Feb 2 - Sun, Feb 8
MLU
Monroe
TYS
Knoxville
$348 Roundtrip, found 10 hours ago
$348
Roundtrip
found 10 hours ago
Select American Airlines flight, departing Mon, Feb 2 from Monroe to Knoxville, returning Sun, Feb 8, priced at $348 found 10 hours ago

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city center is 22 minutes. Flights from $398
TYS
McGhee Tyson
CheapestClosest
Average driving time to city center22 min
Flights from $398
Flights from Monroe (MLU) to Knoxville (TYS)
Origin airport
Monroe Regional
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta
Roundtrip price
$258
Distance
513 mi

Monroe to Knoxville Flights

The cheapest times to fly from Monroe to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Monroe to Knoxville are during the month of February. You can find some of the cheapest flights from Monroe to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Monroe to Knoxville

Sunday is one of the best days to book for cheap flights from Monroe to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Monroe to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Monroe to Knoxville in 2026. You can also book with separate airlines for your outbound and return journeys, from $230 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Monroe to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Monroe to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS) cost?
Get a cheap one-way flight from $230 or cheap return flight from $258 from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS) with Expedia. Enter your travel dates and sort by "Price (lowest to highest)" to see our cheapest flight offers on this route.
What is the cheapest month to fly from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS)?
The cheapest month to fly from MLU to TYS is February, when demand is low. Off-peak season is usually when you'll find cheap fares for travel between these airports.
What is the cheapest airline that flies from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS)?
Use the filters on Expedia to compare airlines and find the cheapest carrier that'll take you from MLU to TYS. Then, sort your results by "Price (lowest to highest)" to score the best deal available.
How many flights per day from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS)?
There aren't any daily nonstop flights from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you'll be soaring above the clouds in no time.
What day of the week has the most flights from MLU to TYS?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can vary depending on various factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS)?
Opt for a flight from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the risk of delays and cancellations. Later departures are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG's global flight data platform.
Is it cheaper to buy a plane ticket from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS) last-minute?
Waiting until just before your departure to book a ticket from MLU to TYS generally means paying more. Although you may find some last-minute deals, they're not always guaranteed. Allow some flexibility in your schedule for the best chance of snagging a bargain.
Is it cheaper to book a MLU to TYS flight and hotel package?
Compared with arranging flights and hotels separately, booking a MLU to TYS flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place takes the hassle out of planning your trip. Just pick your flights and select from our wide range of stays, then personalize your trip with extras like activities, tours and car rentals.
Can I cancel or change the date of my flight from Monroe Regional Airport (MLU) to McGhee Tyson Airport (TYS)?
Usually, it's possible to reschedule or cancel your MLU to TYS flight. However, if the booking was made more than 24 hours ago, additional charges may apply. Check your airline's policies in your itinerary to see what changes are possible and whether any costs are involved. You'll also find more information on our Customer Service portal.

Explore a world of travel with Expedia

*Available to One Key members.