$115 Cheap Flights from Milwaukee (MKE) to Des Moines (DSM)

View $115 flight on Wed, May 21, 2025Opens in a new window

Popular airlines from General Mitchell Intl. Airport (MKE) to Des Moines International Airport (DSM)

Find available prices by choosing your travel dates.

Cheap Flights from Milwaukee to Des Moines (MKE-DSM)

Prices were available within the past 7 days and start at $115 for one-way flights and $229 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Wed, May 21 - Sun, May 25
MKE
Milwaukee
DSM
Des Moines
$229 Roundtrip, found 1 day ago
$229
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, May 21 from Milwaukee to Des Moines, returning Sun, May 25, priced at $229 found 1 day ago
Delta
Sat, May 17 - Sun, May 25
MKE
Milwaukee
DSM
Des Moines
$240 Roundtrip, found 1 day ago
$240
Roundtrip
found 1 day ago
Select Delta flight, departing Sat, May 17 from Milwaukee to Des Moines, returning Sun, May 25, priced at $240 found 1 day ago
Delta
Wed, May 21 - Mon, May 26
MKE
Milwaukee
DSM
Des Moines
$242 Roundtrip, found 1 day ago
$242
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, May 21 from Milwaukee to Des Moines, returning Mon, May 26, priced at $242 found 1 day ago
Delta
Fri, May 30 - Tue, Jun 17
MKE
Milwaukee
DSM
Des Moines
$244 Roundtrip, found 5 days ago
$244
Roundtrip
found 5 days ago
Select Delta flight, departing Fri, May 30 from Milwaukee to Des Moines, returning Tue, Jun 17, priced at $244 found 5 days ago
American Airlines
Sat, Jul 12 - Tue, Jul 15
MKE
Milwaukee
DSM
Des Moines
$253 Roundtrip, found 4 days ago
$253
Roundtrip
found 4 days ago
Select American Airlines flight, departing Sat, Jul 12 from Milwaukee to Des Moines, returning Tue, Jul 15, priced at $253 found 4 days ago
American Airlines
Tue, Jun 3 - Thu, Jun 5
MKE
Milwaukee
DSM
Des Moines
$255 Roundtrip, found 1 day ago
$255
Roundtrip
found 1 day ago
Select American Airlines flight, departing Tue, Jun 3 from Milwaukee to Des Moines, returning Thu, Jun 5, priced at $255 found 1 day ago
Southwest Airlines
Sat, Jul 12 - Tue, Jul 15
MKE
Milwaukee
DSM
Des Moines
$256 Roundtrip, found 4 days ago
$256
Roundtrip
found 4 days ago
Select Southwest Airlines flight, departing Sat, Jul 12 from Milwaukee to Des Moines, returning Tue, Jul 15, priced at $256 found 4 days ago
United
Tue, Jun 3 - Thu, Jun 5
MKE
Milwaukee
DSM
Des Moines
$258 Roundtrip, found 1 day ago
$258
Roundtrip
found 1 day ago
Select United flight, departing Tue, Jun 3 from Milwaukee to Des Moines, returning Thu, Jun 5, priced at $258 found 1 day ago
Southwest Airlines
Tue, May 20 - Thu, May 22
MKE
Milwaukee
DSM
Des Moines
$260 Roundtrip, found 3 days ago
$260
Roundtrip
found 3 days ago
Select Southwest Airlines flight, departing Tue, May 20 from Milwaukee to Des Moines, returning Thu, May 22, priced at $260 found 3 days ago
Delta
Wed, May 21 - Fri, May 23
MKE
Milwaukee
DSM
Des Moines
$261 Roundtrip, found 1 day ago
$261
Roundtrip
found 1 day ago
Select Delta flight, departing Wed, May 21 from Milwaukee to Des Moines, returning Fri, May 23, priced at $261 found 1 day ago
Flights from Milwaukee (MKE) to Des Moines (DSM)
Origin airport
General Mitchell Intl.
Destination airport
Des Moines Intl.
Airlines serving
American Airlines, Delta, Southwest Airlines, United
Roundtrip price
$228
Distance
309 mi

Milwaukee to Des Moines Flights

The cheapest times to fly from Milwaukee to Des Moines

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Milwaukee to Des Moines are during the month of May. You can find some of the cheapest flights from Milwaukee to Des Moines with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Milwaukee to Des Moines

Sunday is one of the best days to book for cheap flights from Milwaukee to Des Moines: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Milwaukee to Des Moines

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Milwaukee to Des Moines in 2025. You can also book with separate airlines for your outbound and return journeys, from $115 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Milwaukee to Des Moines flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Milwaukee to Des Moines airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from General Mitchell Intl. Airport (MKE) to Des Moines Intl. Airport (DSM) cost?
Discover the latest flight deals from MKE to DSM by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MKE to DSM?
The cheapest flights from MKE to DSM are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MKE to DSM?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from MKE to DSM. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from General Mitchell Intl. Airport (MKE) to Des Moines Intl. Airport (DSM)?
Nonstop flights from General Mitchell Intl. Airport (MKE) to Des Moines Intl. Airport (DSM) aren’t available daily, so you’ll need to take a flight with a layover. Explore your options with Expedia’s filters. Enter your travel dates and select either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from MKE to DSM?
You’ll usually find Tuesday the quietest day for flights, while Fridays are often the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from General Mitchell Intl. Airport (MKE) to Des Moines Intl. Airport (DSM)?
To touch down at Des Moines Intl. Airport (DSM) on time, book a flight that leaves General Mitchell Intl. Airport (MKE) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this hour.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from General Mitchell Intl. Airport (MKE) to Des Moines Intl. Airport (DSM) last-minute?
Booking your ticket from MKE to DSM shortly before your journey is typically more expensive. But if there’s some wiggle room with your travel dates and times, you could grab a cheap last-minute fare.
Is it cheaper to book a MKE to DSM flight and hotel package?
Booking a MKE to DSM flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Pick from our impressive range of hotels and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from General Mitchell Intl. Airport (MKE) to Des Moines Intl. Airport (DSM)?
In most cases, you can cancel or reschedule your MKE to DSM flight. However, additional charges may apply, especially if you booked over 24 hours ago. Double-check your itinerary for the airline’s fees and policies on flight changes, or if you need more details, head to our Customer Service portal.

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*Available to One Key members.