$304 Cheap Flights from Mexico City (MEX) to Knoxville (TYS)

View $304 flight on Mon, Jun 2, 2025Opens in a new window

Popular airlines from Benito Juarez International Airport (MEX) to McGhee Tyson Airport (TYS)

  • Plan, book, fly with confidence

  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 30% on select hotels after you book a flight*
  • one key icon
    Earn twice
    Earn your airline miles on top of our OneKeyCash
    Learn about One Key
Find available prices by choosing your travel dates.

Cheap Flights from Mexico City to Knoxville (MEX-TYS)

Prices were available within the past 7 days and start at $304 for one-way flights and $497 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Fri, May 23 - Mon, Jun 2
MEX
Mexico City
TYS
Knoxville
$497 Roundtrip, found 3 hours ago
$497
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, May 23 from Mexico City to Knoxville, returning Mon, Jun 2, priced at $497 found 3 hours ago
American Airlines
Fri, May 23 - Mon, Jun 2
MEX
Mexico City
TYS
Knoxville
$504 Roundtrip, found 3 hours ago
$504
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, May 23 from Mexico City to Knoxville, returning Mon, Jun 2, priced at $504 found 3 hours ago
American Airlines
Fri, May 23 - Mon, Jun 2
MEX
Mexico City
TYS
Knoxville
$507 Roundtrip, found 3 hours ago
$507
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, May 23 from Mexico City to Knoxville, returning Mon, Jun 2, priced at $507 found 3 hours ago
Aeromexico
Fri, May 9 - Tue, May 13
MEX
Mexico City
TYS
Knoxville
$510 Roundtrip, found 2 days ago
$510
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Fri, May 9 from Mexico City to Knoxville, returning Tue, May 13, priced at $510 found 2 days ago
Delta
Fri, May 23 - Mon, Jun 2
MEX
Mexico City
TYS
Knoxville
$510 Roundtrip, found 3 hours ago
$510
Roundtrip
found 3 hours ago
Select Delta flight, departing Fri, May 23 from Mexico City to Knoxville, returning Mon, Jun 2, priced at $510 found 3 hours ago
United
Fri, May 23 - Mon, Jun 2
MEX
Mexico City
TYS
Knoxville
$510 Roundtrip, found 3 hours ago
$510
Roundtrip
found 3 hours ago
Select United flight, departing Fri, May 23 from Mexico City to Knoxville, returning Mon, Jun 2, priced at $510 found 3 hours ago
United
Fri, May 23 - Mon, Jun 2
MEX
Mexico City
TYS
Knoxville
$515 Roundtrip, found 3 hours ago
$515
Roundtrip
found 3 hours ago
Select United flight, departing Fri, May 23 from Mexico City to Knoxville, returning Mon, Jun 2, priced at $515 found 3 hours ago
American Airlines
Fri, May 23 - Mon, Jun 2
MEX
Mexico City
TYS
Knoxville
$517 Roundtrip, found 3 hours ago
$517
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, May 23 from Mexico City to Knoxville, returning Mon, Jun 2, priced at $517 found 3 hours ago
American Airlines
Fri, May 23 - Mon, Jun 2
MEX
Mexico City
TYS
Knoxville
$520 Roundtrip, found 3 hours ago
$520
Roundtrip
found 3 hours ago
Select American Airlines flight, departing Fri, May 23 from Mexico City to Knoxville, returning Mon, Jun 2, priced at $520 found 3 hours ago
Air Canada
Fri, May 23 - Sat, Jul 12
MEX
Mexico City
TYS
Knoxville
$1,091 Roundtrip, found 5 days ago
$1,091
Roundtrip
found 5 days ago
Select Air Canada flight, departing Fri, May 23 from Mexico City to Knoxville, returning Sat, Jul 12, priced at $1,091 found 5 days ago
Flights from Mexico City (MEX) to Knoxville (TYS)
Origin airport
Mexico City Intl.
Destination airport
McGhee Tyson
Airlines serving
Aeromexico, Air Canada, American Airlines, Delta, United
Roundtrip price
$497
Distance
1456 mi

Mexico City to Knoxville Flights

The cheapest times to fly from Mexico City to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mexico City to Knoxville are during the month of May. You can find some of the cheapest flights from Mexico City to Knoxville with Expedia's search tool and vast selection of airlines.

 

The best time to book a flight from Mexico City to Knoxville

Sunday is one of the best days to book for cheap flights from Mexico City to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

 

How to find cheap round-trip tickets from Mexico City to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mexico City to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $304 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

 

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mexico City to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

 

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mexico City to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

 

*Terms apply.

 

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

 

Frequently asked questions

How much does a flight from Mexico City Intl. Airport (MEX) to McGhee Tyson Airport (TYS) cost?
Discover the latest flight deals from MEX to TYS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MEX to TYS?
The cheapest flights from MEX to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MEX to TYS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from MEX to TYS. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Mexico City Intl. Airport (MEX) to McGhee Tyson Airport (TYS)?
Direct flights from Mexico City Intl. Airport (MEX) to McGhee Tyson Airport (TYS) aren’t available daily, so you’ll need to take a flight with a layover. Explore your options with Expedia’s filter tool. Enter your travel details and click on either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from MEX to TYS?
Friday is typically the busiest day for flights, while Tuesday tends to be the quietest.* Keep in mind that flight schedules can vary depending on a number of factors, such as the time of year and carrier.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Mexico City Intl. Airport (MEX) to McGhee Tyson Airport (TYS)?
To avoid potential delays on the Mexico City Intl. Airport (MEX) to McGhee Tyson Airport (TYS) route, travel before 3 PM. Flights after this time have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Mexico City Intl. Airport (MEX) to McGhee Tyson Airport (TYS) last-minute?
Booking your ticket from MEX to TYS right before your trip is typically more expensive. But if there’s some wiggle room with your itinerary, you could land a cheap last-minute fare.
Is it cheaper to book a MEX to TYS flight and hotel package?
Compared with arranging hotels and flights separately, booking a MEX to TYS flight and hotel package with Expedia could result in significant savings. Better still, having it all in one place will take the stress out of planning your trip. Simply secure your flights and select from our wide range of hotels, then customize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Mexico City Intl. Airport (MEX) to McGhee Tyson Airport (TYS)?
If you booked your MEX to TYS flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the ticket type you purchased, additional charges may apply for changes after that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more details.

Explore a world of travel with Expedia

*Available to One Key members.