$107 Cheap Flights from Mexico City (MEX) to Santo Domingo (SDQ)

View $107 flight on Wed, Oct 22, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Mexico City to Santo Domingo (MEX-SDQ)

Prices were available within the past 7 days and start at $107 for one-way flights and $229 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Arajet
Mon, Dec 1 - Mon, Dec 8
NLU
Mexico City
SDQ
Santo Domingo
$229 Roundtrip, found 1 day ago
$229
Roundtrip
found 1 day ago
Select Arajet flight, departing Mon, Dec 1 from Mexico City to Santo Domingo, returning Mon, Dec 8, priced at $229 found 1 day ago
Arajet
Mon, Dec 1 - Mon, Dec 8
NLU
Mexico City
SDQ
Santo Domingo
$273 Roundtrip, found 1 day ago
$273
Roundtrip
found 1 day ago
Select Arajet flight, departing Mon, Dec 1 from Mexico City to Santo Domingo, returning Mon, Dec 8, priced at $273 found 1 day ago
Arajet
Wed, Dec 10 - Mon, Dec 15
NLU
Mexico City
SDQ
Santo Domingo
$273 Roundtrip, found 13 hours ago
$273
Roundtrip
found 13 hours ago
Select Arajet flight, departing Wed, Dec 10 from Mexico City to Santo Domingo, returning Mon, Dec 15, priced at $273 found 13 hours ago
Arajet
Wed, Aug 27 - Fri, Sep 26
NLU
Mexico City
SDQ
Santo Domingo
$281 Roundtrip, found 4 hours ago
$281
Roundtrip
found 4 hours ago
Select Arajet flight, departing Wed, Aug 27 from Mexico City to Santo Domingo, returning Fri, Sep 26, priced at $281 found 4 hours ago
Arajet
Fri, Jul 11 - Thu, Jul 17
NLU
Mexico City
SDQ
Santo Domingo
$288 Roundtrip, found 1 day ago
$288
Roundtrip
found 1 day ago
Select Arajet flight, departing Fri, Jul 11 from Mexico City to Santo Domingo, returning Thu, Jul 17, priced at $288 found 1 day ago
Arajet
Thu, Jun 19 - Thu, Jun 26
NLU
Mexico City
SDQ
Santo Domingo
$291 Roundtrip, found 3 days ago
$291
Roundtrip
found 3 days ago
Select Arajet flight, departing Thu, Jun 19 from Mexico City to Santo Domingo, returning Thu, Jun 26, priced at $291 found 3 days ago
BEK AIR
Wed, Sep 24 - Wed, Oct 1
NLU
Mexico City
SDQ
Santo Domingo
$310 Roundtrip, found 1 day ago
$310
Roundtrip
found 1 day ago
Select BEK AIR flight, departing Wed, Sep 24 from Mexico City to Santo Domingo, returning Wed, Oct 1, priced at $310 found 1 day ago
Aeromexico
Mon, Aug 25 - Mon, Sep 22
MEX
Mexico City
SDQ
Santo Domingo
$330 Roundtrip, found 4 hours ago
$330
Roundtrip
found 4 hours ago
Select Aeromexico flight, departing Mon, Aug 25 from Mexico City to Santo Domingo, returning Mon, Sep 22, priced at $330 found 4 hours ago
Copa
Mon, Nov 10 - Fri, Nov 21
MEX
Mexico City
SDQ
Santo Domingo
$332 Roundtrip, found 4 hours ago
$332
Roundtrip
found 4 hours ago
Select Copa flight, departing Mon, Nov 10 from Mexico City to Santo Domingo, returning Fri, Nov 21, priced at $332 found 4 hours ago
avianca
Fri, Aug 15 - Sat, Aug 23
MEX
Mexico City
SDQ
Santo Domingo
$371 Roundtrip, found 2 hours ago
$371
Roundtrip
found 2 hours ago
Select avianca flight, departing Fri, Aug 15 from Mexico City to Santo Domingo, returning Sat, Aug 23, priced at $371 found 2 hours ago
Flights from Santa Lucía (NLU) to Santo Domingo (SDQ)
Origin airport
Felipe Ángeles Intl.
Destination airport
Las Americas Intl.
Airlines serving
Aeromexico, American Airlines, British Airways, Copa, Delta, Iberia, United, avianca
Roundtrip price
$228
Distance
1916 mi

Mexico City to Santo Domingo Flights

The cheapest times to fly from Mexico City to Santo Domingo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Mexico City to Santo Domingo are during the month of December. You can find some of the cheapest flights from Mexico City to Santo Domingo with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Mexico City to Santo Domingo

Sunday is one of the best days to book for cheap flights from Mexico City to Santo Domingo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Mexico City to Santo Domingo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Mexico City to Santo Domingo in 2025. You can also book with separate airlines for your outbound and return journeys, from $107 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Mexico City to Santo Domingo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Mexico City to Santo Domingo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ) cost?
Discover the latest flight deals from MEX to SDQ by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MEX to SDQ?
The cheapest flights from MEX to SDQ are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ)?
When departing from Mexico City Intl. Airport (MEX), you can hop on a nonstop flight to Las Americas Intl. Airport (SDQ) with Aeromexico.
What is the cheapest airline that flies from MEX to SDQ?
Take off from MEX to SDQ with Aeromexico. This carrier currently offers the cheapest one-way fare on this route, starting from $192. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from MEX on April 25 2025. Prices were last updated on April 24 2025 and have not changed since.
How many flights per day from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ)?
On average, Mexico City Intl. Airport (MEX) only offers 1 nonstop flight to Las Americas Intl. Airport (SDQ) per day. For more choices, try Expedia’s easy-to-use filter tool. Enter your travel details, then select “1 Stop” or “2+ Stops” to discover flights offering layovers.
What are the most popular departure times for flights from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ)?
The 1 AM departures from MEX to SDQ see the highest demand. They can also be more expensive. If you’re looking to save, pick a less crowded time to fly.
What day of the week has the most flights from MEX to SDQ?
If you fly on a Friday, you’ll get the widest range of options for flights from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ).
What is the earliest flight from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ)?
Catch the earliest flight at around 1:01AM UTC-6, heading out of Mexico City Intl. Airport (MEX). You’ll be flying for around 4h 17m, touching down at Las Americas Intl. Airport (SDQ) at approximately 7:18AM UTC-4.
How long does it take to fly from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ)?
It takes about 4 hours and 17 minutes to travel the 1,900 mi from MEX to SDQ.
What is the best time to fly from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ)?
To avoid possible delays on the Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ) route, travel before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Santo Domingo from Mexico City Intl. Airport (MEX)?
Browse your flight options from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ). This is the only airport in Santo Domingo you can touch down at if you’re taking a direct flight.
Is it cheaper to buy a plane ticket from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ) last-minute?
Last-minute bookings from MEX to SDQ are generally more expensive. To secure the lowest rates, start searching for flights well ahead of time. That being said, if your travel plans are flexible, you may land a cheap ticket right before your journey.
Is it cheaper to book a MEX to SDQ flight and hotel package?
Compared with arranging flights and hotels separately, booking a MEX to SDQ flight and hotel package with Expedia could lead to significant savings. Better yet, having everything in one place will take the hassle out of planning your trip. Simply pick your flights and choose from our wide range of hotels, then personalize your trip with other add-ons like activities and car rentals.
Can I cancel or change the date of my flight from Mexico City Intl. Airport (MEX) to Las Americas Intl. Airport (SDQ)?
In most instances, you can modify or cancel your MEX to SDQ flight. However, there may be additional charges, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline’s fees and policies on flight changes, or if you’d like more information, visit our Customer Service portal.

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*Available to One Key members.