$458 Cheap Flights from Chicago (MDW) to Santiago (SCL)

View $458 flight on Tue, Jul 15, 2025Opens in a new window

Popular airlines from Chicago Midway Airport (MDW) to Santiago Intl. Airport (SCL)

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Find available prices by choosing your travel dates.

Cheap Flights from Chicago to Santiago (MDW-SCL)

Prices were available within the past 7 days and start at $458 for one-way flights and $804 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, Sep 9 - Tue, Sep 23
MDW
Chicago
SCL
Santiago
$804 Roundtrip, found 2 hours ago
$804
Roundtrip
found 2 hours ago
Select Delta flight, departing Tue, Sep 9 from Chicago to Santiago, returning Tue, Sep 23, priced at $804 found 2 hours ago
Delta
Thu, Sep 11 - Thu, Sep 18
MDW
Chicago
SCL
Santiago
$808 Roundtrip, found 4 hours ago
$808
Roundtrip
found 4 hours ago
Select Delta flight, departing Thu, Sep 11 from Chicago to Santiago, returning Thu, Sep 18, priced at $808 found 4 hours ago
Delta
Tue, Nov 11 - Tue, Nov 25
MDW
Chicago
SCL
Santiago
$812 Roundtrip, found 3 days ago
$812
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, Nov 11 from Chicago to Santiago, returning Tue, Nov 25, priced at $812 found 3 days ago
Delta
Wed, Oct 8 - Wed, Oct 15
MDW
Chicago
SCL
Santiago
$815 Roundtrip, found 6 days ago
$815
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Oct 8 from Chicago to Santiago, returning Wed, Oct 15, priced at $815 found 6 days ago
Delta
Tue, Dec 2 - Thu, Dec 11
MDW
Chicago
SCL
Santiago
$817 Roundtrip, found 5 days ago
$817
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Dec 2 from Chicago to Santiago, returning Thu, Dec 11, priced at $817 found 5 days ago
Delta
Tue, Dec 2 - Thu, Dec 11
MDW
Chicago
SCL
Santiago
$820 Roundtrip, found 5 days ago
$820
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Dec 2 from Chicago to Santiago, returning Thu, Dec 11, priced at $820 found 5 days ago
Delta
Wed, Oct 8 - Wed, Oct 15
MDW
Chicago
SCL
Santiago
$823 Roundtrip, found 6 days ago
$823
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Oct 8 from Chicago to Santiago, returning Wed, Oct 15, priced at $823 found 6 days ago
Delta
Tue, Dec 2 - Thu, Dec 11
MDW
Chicago
SCL
Santiago
$824 Roundtrip, found 5 days ago
$824
Roundtrip
found 5 days ago
Select Delta flight, departing Tue, Dec 2 from Chicago to Santiago, returning Thu, Dec 11, priced at $824 found 5 days ago
Delta
Wed, Oct 8 - Wed, Oct 15
MDW
Chicago
SCL
Santiago
$831 Roundtrip, found 6 days ago
$831
Roundtrip
found 6 days ago
Select Delta flight, departing Wed, Oct 8 from Chicago to Santiago, returning Wed, Oct 15, priced at $831 found 6 days ago
LATAM Airlines Group
Mon, Jan 5 - Mon, Jan 26
MDW
Chicago
SCL
Santiago
$847 Roundtrip, found 1 day ago
$847
Roundtrip
found 1 day ago
Select LATAM Airlines Group flight, departing Mon, Jan 5 from Chicago to Santiago, returning Mon, Jan 26, priced at $847 found 1 day ago

Frequently asked questions

How much does a flight from Midway Intl. Airport (MDW) to Arturo Merino Benitez Airport (SCL) cost?
Discover the latest flight deals from MDW to SCL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MDW to SCL?
The cheapest flights from MDW to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from MDW to SCL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from MDW to SCL. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Midway Intl. Airport (MDW) to Arturo Merino Benitez Airport (SCL)?
There aren’t any daily nonstop flights from Midway Intl. Airport (MDW) to Arturo Merino Benitez Airport (SCL). But you can book flights with layovers. Filter your search on Expedia to include one or more stops, and you’ll be on your way in no time at all.
What day of the week has the most flights from MDW to SCL?
Friday is generally the busiest day for flights, while Tuesday tends to be the quietest.* Remember that flight schedules can change based on various factors, such as the season and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Midway Intl. Airport (MDW) to Arturo Merino Benitez Airport (SCL)?
Book a flight from Midway Intl. Airport (MDW) to Arturo Merino Benitez Airport (SCL) that leaves before 3 PM to reduce the likelihood of delays and cancellations. Departures later than this have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Midway Intl. Airport (MDW) to Arturo Merino Benitez Airport (SCL) last-minute?
Booking your ticket from MDW to SCL right before your trip is usually more expensive. But if there’s some wiggle room with your departure times and dates, you could grab a cheap last-minute fare.
Is it cheaper to book a MDW to SCL flight and hotel package?
Opting for a MDW to SCL flight and hotel package is generally cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip in one place. Choose from our wide range of accommodations and then add car rentals, activities and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Midway Intl. Airport (MDW) to Arturo Merino Benitez Airport (SCL)?
If you reserved your MDW to SCL flight in the last 24 hours, you may be able to cancel or modify it at no cost. Depending on the airline and the fare type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal for more details.
*Available to One Key members.