$161 Cheap Flights from Medellín (MDE) to Panama City (PTY)

View $161 flight on Wed, May 7, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)

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Find available prices by choosing your travel dates.

Cheap Flights from Medellín to Panama City (MDE-PTY)

Prices were available within the past 7 days and start at $161 for one-way flights and $259 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Wed, May 7 - Wed, May 14
MDE
Medellin
PTY
Panama City
$259 Roundtrip, found 4 hours ago
$259
Roundtrip
found 4 hours ago
Select Copa flight, departing Wed, May 7 from Medellin to Panama City, returning Wed, May 14, priced at $259 found 4 hours ago
Copa
Wed, May 7 - Wed, May 14
MDE
Medellin
PTY
Panama City
$270 Roundtrip, found 4 hours ago
$270
Roundtrip
found 4 hours ago
Select Copa flight, departing Wed, May 7 from Medellin to Panama City, returning Wed, May 14, priced at $270 found 4 hours ago
avianca
Fri, May 2 - Mon, May 5
MDE
Medellin
PTY
Panama City
$281 Roundtrip, found 1 day ago
$281
Roundtrip
found 1 day ago
Select avianca flight, departing Fri, May 2 from Medellin to Panama City, returning Mon, May 5, priced at $281 found 1 day ago
Copa
Fri, Aug 15 - Mon, Aug 18
MDE
Medellin
PTY
Panama City
$283 Roundtrip, found 1 hour ago
$283
Roundtrip
found 1 hour ago
Select Copa flight, departing Fri, Aug 15 from Medellin to Panama City, returning Mon, Aug 18, priced at $283 found 1 hour ago
Copa
Sun, May 18 - Tue, May 27
MDE
Medellin
PTY
Panama City
$293 Roundtrip, found 3 hours ago
$293
Roundtrip
found 3 hours ago
Select Copa flight, departing Sun, May 18 from Medellin to Panama City, returning Tue, May 27, priced at $293 found 3 hours ago
Copa
Sat, Jul 5 - Wed, Jul 9
MDE
Medellin
PTY
Panama City
$294 Roundtrip, found 3 hours ago
$294
Roundtrip
found 3 hours ago
Select Copa flight, departing Sat, Jul 5 from Medellin to Panama City, returning Wed, Jul 9, priced at $294 found 3 hours ago
Copa
Sun, May 18 - Tue, May 27
MDE
Medellin
PTY
Panama City
$296 Roundtrip, found 3 hours ago
$296
Roundtrip
found 3 hours ago
Select Copa flight, departing Sun, May 18 from Medellin to Panama City, returning Tue, May 27, priced at $296 found 3 hours ago
Copa
Wed, May 7 - Sat, May 10
MDE
Medellin
PTY
Panama City
$301 Roundtrip, found 4 hours ago
$301
Roundtrip
found 4 hours ago
Select Copa flight, departing Wed, May 7 from Medellin to Panama City, returning Sat, May 10, priced at $301 found 4 hours ago
avianca
Fri, May 9 - Sun, May 11
MDE
Medellin
PTY
Panama City
$302 Roundtrip, found 2 days ago
$302
Roundtrip
found 2 days ago
Select avianca flight, departing Fri, May 9 from Medellin to Panama City, returning Sun, May 11, priced at $302 found 2 days ago
Aeromexico
Sat, Jun 21 - Wed, Jun 25
MDE
Medellin
PTY
Panama City
$539 Roundtrip, found 2 days ago
$539
Roundtrip
found 2 days ago
Select Aeromexico flight, departing Sat, Jun 21 from Medellin to Panama City, returning Wed, Jun 25, priced at $539 found 2 days ago
Flights from Medellín (MDE) to Panama City (PTY)
Origin airport
José María Córdova Intl.
Destination airport
Tocumen Intl.
Airlines serving
Aeromexico, Copa, avianca
Roundtrip price
$259
Distance
336 mi

Medellín to Panama City Flights

The cheapest times to fly from Medellín to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to Panama City are during the month of May. You can find some of the cheapest flights from Medellín to Panama City with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Medellín to Panama City

Sunday is one of the best days to book for cheap flights from Medellín to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Medellín to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $161 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) cost?
Cheap round-trip flights from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) start from $281. This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Avianca flight leaving MDE on May 17 2025 and touching down at PTY. The price was last updated on April 22 2025 and has not changed since.
What is the cheapest month to fly from MDE to PTY?
The cheapest flights from MDE to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
When setting off from Jose Maria Cordova Intl. Airport (MDE), you can hop on a direct flight to Tocumen Intl. Airport (PTY) with Copa Airlines.
What is the cheapest airline that flies from MDE to PTY?
Right now, the cheapest carrier operating one-way flights from MDE to PTY is Avianca. You can take off on this route from $161. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from MDE on May 28 2025. Prices were last updated on April 22 2025 and have not changed since.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
With, on average, 9 direct flights that operate from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) each day, you’ll be soaring through the skies in no time.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
More passengers fly between MDE and PTY at 11 AM than at any other point in the day. Looking for a quieter experience? Consider flying outside peak hours and you’re likely to save on your fare as well.
What day of the week has the most flights from MDE to PTY?
Depart on a Friday if you’re looking for the largest selection of flights from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY).
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
Hop on the earliest flight at around 5:05AM UTC-5, departing from Jose Maria Cordova Intl. Airport (MDE). You’ll be in the air for around 1h 29m, arriving at Tocumen Intl. Airport (PTY) at approximately 6:34AM UTC-5.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
The average flight time from MDE to PTY is 1 hour and 27 minutes, covering a distance of 340 mi.
What airline has the least delays from MDE to PTY?
With 91% of flights generally landing on schedule, Copa Airlines has the best on-time performance for direct flights from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY). To keep track of your flight status and get notifications if anything changes, use the Expedia App.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
Book a flight from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this hour are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Panama City from Jose Maria Cordova Intl. Airport (MDE)?
You can touch down at Tocumen Intl. Airport (PTY) or Panama Pacifico Intl. Airport (BLB) when traveling to Panama City on a direct flight from Jose Maria Cordova Intl. Airport (MDE).
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY) last-minute?
Holding off until right before your break to book a flight from MDE to PTY often results in higher prices. While you may find some last-minute deals, there’s no guarantee. Keep your travel schedule open for the best chance of landing a bargain.
Is it cheaper to book a MDE to PTY flight and hotel package?
Opting for a MDE to PTY flight and hotel package tends to be cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Pick from our extensive range of hotels and then add activities, car rentals and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
Typically, you’re able to cancel or reschedule your MDE to PTY flight. However, there may be additional charges, especially if your booking was made more than 24 hours ago. Check your itinerary for the airline’s policies and fees on flight changes, or if you need more details, head to our Customer Service portal.

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*Available to One Key members.