$269 Cheap Flights from Medellín (MDE) to São Paulo (GRU)

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Cheap Flights from Medellín to São Paulo (MDE-GRU)

Prices were available within the past 7 days and start at $269 for one-way flights and $394 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, May 22 - Tue, May 27
MDE
Medellin
GRU
Sao Paulo
$394 Roundtrip, found 5 hours ago
$394
Roundtrip
found 5 hours ago
Select Copa flight, departing Thu, May 22 from Medellin to Sao Paulo, returning Tue, May 27, priced at $394 found 5 hours ago
Copa
Thu, Jan 22 - Mon, Jan 26
MDE
Medellin
GRU
Sao Paulo
$405 Roundtrip, found 12 hours ago
$405
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, Jan 22 from Medellin to Sao Paulo, returning Mon, Jan 26, priced at $405 found 12 hours ago
Copa
Thu, Jan 22 - Mon, Jan 26
MDE
Medellin
GRU
Sao Paulo
$422 Roundtrip, found 12 hours ago
$422
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, Jan 22 from Medellin to Sao Paulo, returning Mon, Jan 26, priced at $422 found 12 hours ago
Copa
Thu, Jan 22 - Mon, Jan 26
MDE
Medellin
GRU
Sao Paulo
$438 Roundtrip, found 12 hours ago
$438
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, Jan 22 from Medellin to Sao Paulo, returning Mon, Jan 26, priced at $438 found 12 hours ago
Copa
Sun, May 25 - Wed, May 28
MDE
Medellin
GRU
Sao Paulo
$442 Roundtrip, found 13 hours ago
$442
Roundtrip
found 13 hours ago
Select Copa flight, departing Sun, May 25 from Medellin to Sao Paulo, returning Wed, May 28, priced at $442 found 13 hours ago
avianca
Mon, Aug 4 - Sun, Aug 10
MDE
Medellin
GRU
Sao Paulo
$446 Roundtrip, found 1 hour ago
$446
Roundtrip
found 1 hour ago
Select avianca flight, departing Mon, Aug 4 from Medellin to Sao Paulo, returning Sun, Aug 10, priced at $446 found 1 hour ago
avianca
Thu, Jun 5 - Wed, Jun 11
MDE
Medellin
GRU
Sao Paulo
$446 Roundtrip, found 10 hours ago
$446
Roundtrip
found 10 hours ago
Select avianca flight, departing Thu, Jun 5 from Medellin to Sao Paulo, returning Wed, Jun 11, priced at $446 found 10 hours ago
Copa
Thu, Jan 22 - Mon, Jan 26
MDE
Medellin
GRU
Sao Paulo
$448 Roundtrip, found 12 hours ago
$448
Roundtrip
found 12 hours ago
Select Copa flight, departing Thu, Jan 22 from Medellin to Sao Paulo, returning Mon, Jan 26, priced at $448 found 12 hours ago
LATAM Airlines Group
Wed, May 21 - Sat, May 24
MDE
Medellin
GRU
Sao Paulo
$506 Roundtrip, found 10 hours ago
$506
Roundtrip
found 10 hours ago
Select LATAM Airlines Group flight, departing Wed, May 21 from Medellin to Sao Paulo, returning Sat, May 24, priced at $506 found 10 hours ago
GOL Linhas Aereas S.A.
Mon, Aug 4 - Sun, Aug 10
MDE
Medellin
GRU
Sao Paulo
$800 Roundtrip, found 1 hour ago
$800
Roundtrip
found 1 hour ago
Select GOL Linhas Aereas S.A. flight, departing Mon, Aug 4 from Medellin to Sao Paulo, returning Sun, Aug 10, priced at $800 found 1 hour ago
Flights from Medellín (MDE) to São Paulo (GRU)
Origin airport
José María Córdova Intl.
Destination airport
Guarulhos - Governor André Franco Montoro Intl.
Airlines serving
Copa, GOL Linhas Aereas S.A., LATAM Airlines Group, avianca
Roundtrip price
$394
Distance
2827 mi

Medellín to São Paulo Flights

The cheapest times to fly from Medellín to São Paulo

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Medellín to São Paulo are during the month of May. You can find some of the cheapest flights from Medellín to São Paulo with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Medellín to São Paulo

Sunday is one of the best days to book for cheap flights from Medellín to São Paulo: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Medellín to São Paulo

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Medellín to São Paulo in 2025. You can also book with separate airlines for your outbound and return journeys, from $269 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Medellín to São Paulo flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Medellín to São Paulo airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) cost?
Discover the latest flight deals from MDE to GRU by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from MDE to GRU?
The cheapest flights from MDE to GRU are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
When departing from Jose Maria Cordova Intl. Airport (MDE), you can board a direct flight to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) with AVIANCA.
What is the cheapest airline that flies from MDE to GRU?
With prices as low as $274 for a one-way flight from MDE to GRU, Avianca is currently the cheapest carrier for this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from MDE on June 12 2025. Prices were last updated on April 24 2025 and have not changed since.
How many flights per day from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
On average, Jose Maria Cordova Intl. Airport (MDE) has 3 direct flights to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) each week. If you’re looking for more options, use Expedia’s filters to discover flights with one or two stops. Squeeze in a quick visit to another location or simply break up your trip.
What are the most popular departure times for flights from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
Flights between MDE and GRU are busiest at 5 PM. If you’re after a more relaxed trip and potentially cheaper fares, look for a time when demand is lower.
What day of the week has the most flights from MDE to GRU?
Thursday has the most flights from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU). Consider jetting off on this day and you’ll have the best chance of finding a departure that fits your schedule.
What is the earliest flight from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
Jose Maria Cordova Intl. Airport (MDE)’s earliest flight to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) takes off at approximately 5:45PM UTC-5. With a total flight time of 6h 10m, you’ll land at around 1:55AM UTC-3.
How long does it take to fly from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
Flights from MDE to GRU have an average travel time of 6 hours and 10 minutes. The distance between the two is 2,800 mi.
What is the best time to fly from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
To touch down at Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) on time, opt for a flight that takes off from Jose Maria Cordova Intl. Airport (MDE) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Sao Paulo from Jose Maria Cordova Intl. Airport (MDE)?
If you’ve booked a direct flight from Jose Maria Cordova Intl. Airport (MDE) to Sao Paulo, Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) is the only airport you can land at.
Is it cheaper to buy a plane ticket from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU) last-minute?
Booking your flight from MDE to GRU right before your trip is typically more expensive. However, if there’s some wiggle room with your schedule, you could grab a cheap last-minute fare.
Is it cheaper to book a MDE to GRU flight and hotel package?
You’ll typically save money by securing a MDE to GRU flight and hotel package compared to booking separately. In fact, you could save hundreds of dollars by bundling with Expedia. And it’s simple to manage it all in one place. Once you’ve selected your preferred flights and accommodations, consider other add-ons like tours, activities and car rentals.
Can I cancel or change the date of my flight from Jose Maria Cordova Intl. Airport (MDE) to Guarulhos - Governor Andre Franco Montoro Intl. Airport (GRU)?
Typically, you’re able to cancel or reschedule your MDE to GRU flight. However, there may be additional charges, especially if you booked over 24 hours ago. Double-check your itinerary for the airline’s guidelines and fees on flight changes, or if you’d like more details, go to our Customer Service portal.

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*Available to One Key members.