$826 Cheap Flights from Lyon (LYS) to St. Louis (STL)

View $826 flight on Sun, Oct 12, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Lyon to St. Louis (LYS-STL)

Prices were available within the past 7 days and start at $826 for one-way flights and $714 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Thu, Jun 5 - Mon, Jun 23
LYS
Lyon
STL
St. Louis
$714 Roundtrip, found 13 hours ago
$714
Roundtrip
found 13 hours ago
Select United flight, departing Thu, Jun 5 from Lyon to St. Louis, returning Mon, Jun 23, priced at $714 found 13 hours ago
United
Wed, Jun 4 - Tue, Jun 17
LYS
Lyon
STL
St. Louis
$714 Roundtrip, found 13 hours ago
$714
Roundtrip
found 13 hours ago
Select United flight, departing Wed, Jun 4 from Lyon to St. Louis, returning Tue, Jun 17, priced at $714 found 13 hours ago
United
Thu, Jun 5 - Wed, Jun 25
LYS
Lyon
STL
St. Louis
$724 Roundtrip, found 13 hours ago
$724
Roundtrip
found 13 hours ago
Select United flight, departing Thu, Jun 5 from Lyon to St. Louis, returning Wed, Jun 25, priced at $724 found 13 hours ago
United
Mon, Jun 16 - Mon, Jun 30
LYS
Lyon
STL
St. Louis
$726 Roundtrip, found 13 hours ago
$726
Roundtrip
found 13 hours ago
Select United flight, departing Mon, Jun 16 from Lyon to St. Louis, returning Mon, Jun 30, priced at $726 found 13 hours ago
United
Wed, Jun 4 - Fri, Jun 13
LYS
Lyon
STL
St. Louis
$728 Roundtrip, found 13 hours ago
$728
Roundtrip
found 13 hours ago
Select United flight, departing Wed, Jun 4 from Lyon to St. Louis, returning Fri, Jun 13, priced at $728 found 13 hours ago
United
Wed, May 21 - Wed, Jun 4
LYS
Lyon
STL
St. Louis
$731 Roundtrip, found 13 hours ago
$731
Roundtrip
found 13 hours ago
Select United flight, departing Wed, May 21 from Lyon to St. Louis, returning Wed, Jun 4, priced at $731 found 13 hours ago
Air Canada
Mon, May 26 - Tue, Jun 10
LYS
Lyon
STL
St. Louis
$737 Roundtrip, found 13 hours ago
$737
Roundtrip
found 13 hours ago
Select Air Canada flight, departing Mon, May 26 from Lyon to St. Louis, returning Tue, Jun 10, priced at $737 found 13 hours ago
Delta
Thu, Jun 5 - Sat, Jun 21
LYS
Lyon
STL
St. Louis
$745 Roundtrip, found 13 hours ago
$745
Roundtrip
found 13 hours ago
Select Delta flight, departing Thu, Jun 5 from Lyon to St. Louis, returning Sat, Jun 21, priced at $745 found 13 hours ago
American Airlines
Sat, Jun 7 - Sat, Jun 21
LYS
Lyon
STL
St. Louis
$746 Roundtrip, found 13 hours ago
$746
Roundtrip
found 13 hours ago
Select American Airlines flight, departing Sat, Jun 7 from Lyon to St. Louis, returning Sat, Jun 21, priced at $746 found 13 hours ago
British Airways
Sat, Jun 14 - Wed, Jul 2
LYS
Lyon
STL
St. Louis
$783 Roundtrip, found 13 hours ago
$783
Roundtrip
found 13 hours ago
Select British Airways flight, departing Sat, Jun 14 from Lyon to St. Louis, returning Wed, Jul 2, priced at $783 found 13 hours ago
Flights from Lyon (LYS) to St. Louis (STL)
Origin airport
Saint-Exupery
Destination airport
Lambert-St. Louis Intl.
Airlines serving
Aer Lingus, Air Canada, Air France, American Airlines, British Airways, Delta, Iberia, KLM, Lufthansa, Turkish Airlines, United
Roundtrip price
$714
Distance
4604 mi

Lyon to St. Louis Flights

The cheapest times to fly from Lyon to St. Louis

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Lyon to St. Louis are during the month of June. You can find some of the cheapest flights from Lyon to St. Louis with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Lyon to St. Louis

Sunday is one of the best days to book for cheap flights from Lyon to St. Louis: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Lyon to St. Louis

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Lyon to St. Louis in 2025. You can also book with separate airlines for your outbound and return journeys, from $826 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Lyon to St. Louis flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Lyon to St. Louis airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Saint-Exupery Airport (LYS) to Lambert-St. Louis Intl. Airport (STL) cost?
Discover the latest flight deals from LYS to STL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from LYS to STL?
The cheapest flights from LYS to STL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from LYS to STL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from LYS to STL. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Saint-Exupery Airport (LYS) to Lambert-St. Louis Intl. Airport (STL)?
There aren’t any daily direct flights departing from Saint-Exupery Airport (LYS) to Lambert-St. Louis Intl. Airport (STL). But you can opt for flights with layovers. Filter your search results on Expedia to include one or two stops, and you’ll be cruising above the clouds in no time.
What day of the week has the most flights from LYS to STL?
Typically you’ll find the widest variety of flight choices on a Friday. Tuesdays are often the quietest.* But this can vary based on the time of year, carrier and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Saint-Exupery Airport (LYS) to Lambert-St. Louis Intl. Airport (STL)?
Opt for a flight from Saint-Exupery Airport (LYS) to Lambert-St. Louis Intl. Airport (STL) that takes off before 3 PM to reduce the risk of delays and cancellations. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Saint-Exupery Airport (LYS) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Last-minute fares from LYS to STL are generally more expensive. To secure the lowest rates, start looking for flights ahead of time. That being said, if you’re flexible with your travel dates, it’s possible to land a cheap fare right before your journey.
Is it cheaper to book a LYS to STL flight and hotel package?
Opting for a LYS to STL flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels in one place. Choose from our impressive range of hotels and then add flights, activities and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Saint-Exupery Airport (LYS) to Lambert-St. Louis Intl. Airport (STL)?
If you booked your LYS to STL flight in the last 24 hours, you may be able to modify or cancel it without fees. Depending on the airline and the ticket type you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.