$144 Cheap Flights from Jacksonville (JAX) to Knoxville (TYS)

View $144 flight on Sat, Jun 21, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Jacksonville to Knoxville (JAX-TYS)

Prices were available within the past 7 days and start at $144 for one-way flights and $221 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, May 13 - Wed, May 21
JAX
Jacksonville
TYS
Knoxville
$221 Roundtrip, found 2 days ago
$221
Roundtrip
found 2 days ago
Select American Airlines flight, departing Tue, May 13 from Jacksonville to Knoxville, returning Wed, May 21, priced at $221 found 2 days ago
Delta
Tue, May 13 - Wed, May 21
JAX
Jacksonville
TYS
Knoxville
$221 Roundtrip, found 2 days ago
$221
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, May 13 from Jacksonville to Knoxville, returning Wed, May 21, priced at $221 found 2 days ago
Delta
Fri, May 9 - Tue, May 20
JAX
Jacksonville
TYS
Knoxville
$236 Roundtrip, found 5 days ago
$236
Roundtrip
found 5 days ago
Select Delta flight, departing Fri, May 9 from Jacksonville to Knoxville, returning Tue, May 20, priced at $236 found 5 days ago
Delta
Wed, May 14 - Tue, May 20
JAX
Jacksonville
TYS
Knoxville
$246 Roundtrip, just found
$246
Roundtrip
just found
Select Delta flight, departing Wed, May 14 from Jacksonville to Knoxville, returning Tue, May 20, priced at $246 just found
Delta
Tue, May 13 - Mon, May 19
JAX
Jacksonville
TYS
Knoxville
$250 Roundtrip, found 3 days ago
$250
Roundtrip
found 3 days ago
Select Delta flight, departing Tue, May 13 from Jacksonville to Knoxville, returning Mon, May 19, priced at $250 found 3 days ago
Delta
Sat, May 17 - Tue, May 20
JAX
Jacksonville
TYS
Knoxville
$254 Roundtrip, found 3 hours ago
$254
Roundtrip
found 3 hours ago
Select Delta flight, departing Sat, May 17 from Jacksonville to Knoxville, returning Tue, May 20, priced at $254 found 3 hours ago
American Airlines
Wed, May 14 - Tue, May 20
JAX
Jacksonville
TYS
Knoxville
$271 Roundtrip, just found
$271
Roundtrip
just found
Select American Airlines flight, departing Wed, May 14 from Jacksonville to Knoxville, returning Tue, May 20, priced at $271 just found
Delta
Tue, May 6 - Mon, May 19
JAX
Jacksonville
TYS
Knoxville
$275 Roundtrip, found 2 days ago
$275
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, May 6 from Jacksonville to Knoxville, returning Mon, May 19, priced at $275 found 2 days ago
Delta
Tue, May 13 - Wed, May 21
JAX
Jacksonville
TYS
Knoxville
$279 Roundtrip, found 2 days ago
$279
Roundtrip
found 2 days ago
Select Delta flight, departing Tue, May 13 from Jacksonville to Knoxville, returning Wed, May 21, priced at $279 found 2 days ago
United
Wed, Jun 18 - Wed, Jun 25
JAX
Jacksonville
TYS
Knoxville
$287 Roundtrip, found 4 hours ago
$287
Roundtrip
found 4 hours ago
Select United flight, departing Wed, Jun 18 from Jacksonville to Knoxville, returning Wed, Jun 25, priced at $287 found 4 hours ago
Flights from Jacksonville (JAX) to Knoxville (TYS)
Origin airport
Jacksonville Intl.
Destination airport
McGhee Tyson
Airlines serving
American Airlines, Delta, United
Roundtrip price
$220
Distance
390 mi

Jacksonville to Knoxville Flights

The cheapest times to fly from Jacksonville to Knoxville

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Jacksonville to Knoxville are during the month of May. You can find some of the cheapest flights from Jacksonville to Knoxville with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Jacksonville to Knoxville

Sunday is one of the best days to book for cheap flights from Jacksonville to Knoxville: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Jacksonville to Knoxville

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Jacksonville to Knoxville in 2025. You can also book with separate airlines for your outbound and return journeys, from $144 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Jacksonville to Knoxville flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Jacksonville to Knoxville airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS) cost?
Discover the latest flight deals from JAX to TYS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from JAX to TYS?
The cheapest flights from JAX to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from JAX to TYS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from JAX to TYS. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS)?
On average, you can take your pick of 2 direct flights taking off from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS) weekly. If you can’t find one that suits your schedule, think about hopping on a flight that includes a layover. Filter your search results on Expedia to include one or two stops and choose the best alternative.
What are the most popular departure times for flights from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS)?
The 5 PM departures from JAX to TYS are the most sought after. They can also be more expensive. If you want to save on your fare, choose a less crowded time to fly.
What day of the week has the most flights from JAX to TYS?
If you depart on a Friday, you’ll get the largest range of choices for flights from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS).
What is the earliest flight from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS)?
Hop on the earliest flight at around 5:19PM UTC-5, leaving from Jacksonville Intl. Airport (JAX). You’ll be in the air for about 1h 34m, arriving at McGhee Tyson Airport (TYS) at approximately 6:53PM UTC-5.
How long does it take to fly from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS)?
Flights from JAX to TYS have an average travel time of 1 hour and 34 minutes. The total distance between the two is 390 mi.
What is the best time to fly from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS)?
To land at McGhee Tyson Airport (TYS) on schedule, choose a flight that takes off from Jacksonville Intl. Airport (JAX) before 3 PM. The chance of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for Knoxville from Jacksonville Intl. Airport (JAX)?
Browse your flight options from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS). This is the only airport in Knoxville you can jet into if you’re taking a direct flight.
Is it cheaper to buy a plane ticket from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS) last-minute?
Waiting until just before your trip to book your flight from JAX to TYS often results in higher prices. Although you may find some last-minute discounts, they aren’t always guaranteed. Allow some flexibility in your schedule for a better chance of snagging a bargain.
Is it cheaper to book a JAX to TYS flight and hotel package?
Compared with arranging hotels and flights separately, booking a JAX to TYS flight and hotel package with Expedia could lead to significant savings. Better yet, managing everything in one place takes the hassle out of travel planning. Just secure your flights and choose from our extensive range of stays, then customize your trip with extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Jacksonville Intl. Airport (JAX) to McGhee Tyson Airport (TYS)?
If you reserved your JAX to TYS flight in the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, go to our Customer Service portal for more information.

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*Available to One Key members.