$110 Cheap Flights from Jacksonville (JAX) to St. Louis (STL)

View $110 flight on Thu, Jul 10, 2025Opens in a new window

Popular airlines from Jacksonville International Airport (JAX) to St. Louis Lambert Intl. Airport (STL)

Find available prices by choosing your travel dates.

Cheap Flights from Jacksonville to St. Louis (JAX-STL)

Prices were available within the past 7 days and start at $110 for one-way flights and $214 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
Tue, Jun 3 - Wed, Jun 4
JAX
Jacksonville
STL
St. Louis
$214 Roundtrip, found 2 days ago
$214
Roundtrip
found 2 days ago
Select United flight, departing Tue, Jun 3 from Jacksonville to St. Louis, returning Wed, Jun 4, priced at $214 found 2 days ago
American Airlines
Thu, Jul 10 - Thu, Jul 17
JAX
Jacksonville
STL
St. Louis
$219 Roundtrip, just found
$219
Roundtrip
just found
Select American Airlines flight, departing Thu, Jul 10 from Jacksonville to St. Louis, returning Thu, Jul 17, priced at $219 just found
Delta
Thu, Jul 10 - Thu, Jul 17
JAX
Jacksonville
STL
St. Louis
$219 Roundtrip, just found
$219
Roundtrip
just found
Select Delta flight, departing Thu, Jul 10 from Jacksonville to St. Louis, returning Thu, Jul 17, priced at $219 just found
Delta
Fri, Jun 6 - Wed, Jun 11
JAX
Jacksonville
STL
St. Louis
$220 Roundtrip, found 1 hour ago
$220
Roundtrip
found 1 hour ago
Select Delta flight, departing Fri, Jun 6 from Jacksonville to St. Louis, returning Wed, Jun 11, priced at $220 found 1 hour ago
Delta
Thu, Jul 10 - Thu, Jul 17
JAX
Jacksonville
STL
St. Louis
$222 Roundtrip, just found
$222
Roundtrip
just found
Select Delta flight, departing Thu, Jul 10 from Jacksonville to St. Louis, returning Thu, Jul 17, priced at $222 just found
United
Sat, Oct 25 - Tue, Oct 28
JAX
Jacksonville
STL
St. Louis
$224 Roundtrip, found 1 day ago
$224
Roundtrip
found 1 day ago
Select United flight, departing Sat, Oct 25 from Jacksonville to St. Louis, returning Tue, Oct 28, priced at $224 found 1 day ago
United
Tue, Sep 16 - Sat, Sep 20
JAX
Jacksonville
STL
St. Louis
$227 Roundtrip, found 3 days ago
$227
Roundtrip
found 3 days ago
Select United flight, departing Tue, Sep 16 from Jacksonville to St. Louis, returning Sat, Sep 20, priced at $227 found 3 days ago
Southwest Airlines
Wed, May 28 - Mon, Jun 2
JAX
Jacksonville
STL
St. Louis
$234 Roundtrip, found 4 hours ago
$234
Roundtrip
found 4 hours ago
Select Southwest Airlines flight, departing Wed, May 28 from Jacksonville to St. Louis, returning Mon, Jun 2, priced at $234 found 4 hours ago
Delta
Wed, May 28 - Mon, Jun 2
JAX
Jacksonville
STL
St. Louis
$237 Roundtrip, found 4 hours ago
$237
Roundtrip
found 4 hours ago
Select Delta flight, departing Wed, May 28 from Jacksonville to St. Louis, returning Mon, Jun 2, priced at $237 found 4 hours ago
American Airlines
Thu, Jul 10 - Thu, Jul 17
JAX
Jacksonville
STL
St. Louis
$239 Roundtrip, just found
$239
Roundtrip
just found
Select American Airlines flight, departing Thu, Jul 10 from Jacksonville to St. Louis, returning Thu, Jul 17, priced at $239 just found

Frequently asked questions

How much does a flight from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL) cost?
Pick up cheap return flights starting from $263 from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL). This information is based on the cheapest price found on Expedia for this return journey departing within the next three months. This airfare is for a Southwest Airlines flight leaving JAX on May 12 2025 and touching down at STL. The price was last updated on April 23 2025 and has not changed since.
What is the cheapest month to fly from JAX to STL?
The cheapest flights from JAX to STL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL)?
If you’re departing from Jacksonville Intl. Airport (JAX), you can jump on a nonstop flight to Lambert-St. Louis Intl. Airport (STL) with Southwest Airlines.
What is the cheapest airline that flies from JAX to STL?
With prices as low as $125 for a one-way journey from JAX to STL, Southwest Airlines is currently the cheapest carrier for this route. This fare is based on the lowest price found on Expedia departing within the next three months. The flight takes off from JAX on May 27 2025. Prices were last updated on April 23 2025 and have not changed since.
How many flights per day from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL)?
On average, Jacksonville Intl. Airport (JAX) has 3 direct flights to Lambert-St. Louis Intl. Airport (STL) per week. For more options, take advantage of Expedia’s filters to look for flights with one or more stops. Fit in a quick visit to another destination or just break up your journey.
What are the most popular departure times for flights from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL)?
More travelers fly between JAX and STL at 11 AM than at any other time. Rather go when it’s quieter? Consider flying outside peak hours and you could save on your fare as well.
What day of the week has the most flights from JAX to STL?
If you travel on a Friday, you’ll get the greatest range of choices for flights from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL).
What is the earliest flight from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL)?
Hop on the earliest flight at around 11:50AM UTC-5, heading out of Jacksonville Intl. Airport (JAX). You’ll be in the air for about 2h 20m, arriving at Lambert-St. Louis Intl. Airport (STL) at approximately 1:10PM UTC-6.
How long does it take to fly from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL)?
Flights from JAX to STL have an average travel time of 2 hours and 20 minutes. The total distance between the two is 750 mi.
What is the best time to fly from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL)?
To arrive at Lambert-St. Louis Intl. Airport (STL) on schedule, pick a flight that leaves Jacksonville Intl. Airport (JAX) before 3 PM. The likelihood of cancellations is 22% higher, on average, for departures after this time.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
What airports do you fly into for St. Louis from Jacksonville Intl. Airport (JAX)?
Compare your flight options from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL). This is the only airport in St. Louis you can land at if you’re taking a direct flight.
Is it cheaper to buy a plane ticket from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL) last-minute?
Waiting until just before your departure to book a flight from JAX to STL often results in higher prices. While you might find some last-minute deals, they’re not always guaranteed. Be flexible with your travel plans to maximize your chances of getting a bargain.
Is it cheaper to book a JAX to STL flight and hotel package?
Compared with arranging hotels and flights separately, booking a JAX to STL flight and hotel package with Expedia could result in significant savings. Better still, managing everything in one place will take the hassle out of planning your trip. Just pick your flights and choose from our wide range of hotels, then customize your trip with other add-ons like tours and car rentals.
Can I cancel or change the date of my flight from Jacksonville Intl. Airport (JAX) to Lambert-St. Louis Intl. Airport (STL)?
If you booked your JAX to STL flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you purchased, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, visit our Customer Service portal for more details.
*Available to One Key members.