$222 Cheap Flights from Indianapolis (IND) to Panama City (PTY)

View $222 flight on Sun, Aug 24, 2025Opens in a new window

Popular airlines from Indianapolis Intl. Airport (IND) to Tocumen Intl. Airport (PTY)

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Find available prices by choosing your travel dates.

Cheap Flights from Indianapolis to Panama City (IND-PTY)

Prices were available within the past 7 days and start at $222 for one-way flights and $469 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Sep 9 - Thu, Sep 18
IND
Indianapolis
PTY
Panama City
$469 Roundtrip, found 11 hours ago
$469
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Tue, Sep 9 from Indianapolis to Panama City, returning Thu, Sep 18, priced at $469 found 11 hours ago
Delta
Tue, Sep 9 - Thu, Sep 18
IND
Indianapolis
PTY
Panama City
$469 Roundtrip, found 11 hours ago
$469
Roundtrip
found 11 hours ago
Select Delta flight, departing Tue, Sep 9 from Indianapolis to Panama City, returning Thu, Sep 18, priced at $469 found 11 hours ago
United
Thu, Nov 6 - Tue, Nov 11
IND
Indianapolis
PTY
Panama City
$469 Roundtrip, found 1 hour ago
$469
Roundtrip
found 1 hour ago
Select United flight, departing Thu, Nov 6 from Indianapolis to Panama City, returning Tue, Nov 11, priced at $469 found 1 hour ago
American Airlines
Tue, Sep 9 - Thu, Sep 18
IND
Indianapolis
PTY
Panama City
$474 Roundtrip, found 11 hours ago
$474
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Tue, Sep 9 from Indianapolis to Panama City, returning Thu, Sep 18, priced at $474 found 11 hours ago
Delta
Sun, Aug 17 - Tue, Aug 26
IND
Indianapolis
PTY
Panama City
$477 Roundtrip, found 7 hours ago
$477
Roundtrip
found 7 hours ago
Select Delta flight, departing Sun, Aug 17 from Indianapolis to Panama City, returning Tue, Aug 26, priced at $477 found 7 hours ago
United
Wed, Sep 3 - Tue, Sep 9
IND
Indianapolis
PTY
Panama City
$479 Roundtrip, found 1 day ago
$479
Roundtrip
found 1 day ago
Select United flight, departing Wed, Sep 3 from Indianapolis to Panama City, returning Tue, Sep 9, priced at $479 found 1 day ago
American Airlines
Tue, Sep 9 - Thu, Sep 18
IND
Indianapolis
PTY
Panama City
$480 Roundtrip, found 11 hours ago
$480
Roundtrip
found 11 hours ago
Select American Airlines flight, departing Tue, Sep 9 from Indianapolis to Panama City, returning Thu, Sep 18, priced at $480 found 11 hours ago
Delta
Tue, Jul 22 - Tue, Jul 29
IND
Indianapolis
PTY
Panama City
$485 Roundtrip, found 18 hours ago
$485
Roundtrip
found 18 hours ago
Select Delta flight, departing Tue, Jul 22 from Indianapolis to Panama City, returning Tue, Jul 29, priced at $485 found 18 hours ago
avianca
Fri, May 2 - Tue, May 6
IND
Indianapolis
PTY
Panama City
$979 Roundtrip, found 12 hours ago
$979
Roundtrip
found 12 hours ago
Select avianca flight, departing Fri, May 2 from Indianapolis to Panama City, returning Tue, May 6, priced at $979 found 12 hours ago
Copa
Sun, Aug 24 - Fri, Aug 29
IND
Indianapolis
PTY
Panama City
$1,133 Roundtrip, just found
$1,133
Roundtrip
just found
Select Copa flight, departing Sun, Aug 24 from Indianapolis to Panama City, returning Fri, Aug 29, priced at $1,133 just found

Frequently asked questions

How much does a flight from Indianapolis Intl. Airport (IND) to Tocumen Intl. Airport (PTY) cost?
Discover the latest flight deals from IND to PTY by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from IND to PTY?
The cheapest flights from IND to PTY are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from IND to PTY?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from IND to PTY. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Indianapolis Intl. Airport (IND) to Tocumen Intl. Airport (PTY)?
There aren’t any daily direct flights departing from Indianapolis Intl. Airport (IND) to Tocumen Intl. Airport (PTY). But you can book flights with layovers. Filter your search on Expedia to include one or two stops, and you’ll be soaring above the clouds in no time.
What day of the week has the most flights from IND to PTY?
You’ll typically find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can change from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Indianapolis Intl. Airport (IND) to Tocumen Intl. Airport (PTY)?
Choose a flight from Indianapolis Intl. Airport (IND) to Tocumen Intl. Airport (PTY) that leaves before 3 PM to reduce the risk of cancellations and delays. Departures after this hour have a 22% higher chance of being canceled, on average.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Indianapolis Intl. Airport (IND) to Tocumen Intl. Airport (PTY) last-minute?
Holding off until just before your trip to book a ticket from IND to PTY often results in higher prices. While you may find some last-minute deals, they aren’t always guaranteed. Keep your travel schedule open for a better chance of getting a bargain.
Is it cheaper to book an IND to PTY flight and hotel package?
Securing an IND to PTY flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your trip all in one place. Choose from our impressive range of accommodations and then add car rentals, activities and flights to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Indianapolis Intl. Airport (IND) to Tocumen Intl. Airport (PTY)?
In most instances, you’re able to cancel or reschedule your IND to PTY flight. However, there may be additional charges, especially if you booked more than 24 hours ago. Double-check your itinerary for the airline’s guidelines and fees on flight changes, or if you want more information, visit our Customer Service portal.
*Available to One Key members.