$172 Cheap Flights from Hyannis (HYA) to San Diego (SAN)

View $172 flight on Fri, Jul 25, 2025Opens in a new window

Popular airlines from Hyannis, MA (HYA-Barnstable Municipal) to San Diego Intl. Airport (SAN)

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Find available prices by choosing your travel dates.

Cheap Flights from Hyannis to San Diego (HYA-SAN)

Prices were available within the past 7 days and start at $172 for one-way flights and $759 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

JetBlue Airways
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$759 Roundtrip, found 2 days ago
$759
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $759 found 2 days ago
Cape Air
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$765 Roundtrip, found 2 days ago
$765
Roundtrip
found 2 days ago
Select Cape Air flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $765 found 2 days ago
JetBlue Airways
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$799 Roundtrip, found 2 days ago
$799
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $799 found 2 days ago
Cape Air
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$924 Roundtrip, found 2 days ago
$924
Roundtrip
found 2 days ago
Select Cape Air flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $924 found 2 days ago
JetBlue Airways
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$935 Roundtrip, found 2 days ago
$935
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $935 found 2 days ago
JetBlue Airways
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$941 Roundtrip, found 2 days ago
$941
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $941 found 2 days ago
Cape Air
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$954 Roundtrip, found 2 days ago
$954
Roundtrip
found 2 days ago
Select Cape Air flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $954 found 2 days ago
JetBlue Airways
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$957 Roundtrip, found 2 days ago
$957
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $957 found 2 days ago
JetBlue Airways
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$962 Roundtrip, found 2 days ago
$962
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $962 found 2 days ago
JetBlue Airways
Wed, May 7 - Sun, May 11
HYA
Hyannis
SAN
San Diego
$965 Roundtrip, found 2 days ago
$965
Roundtrip
found 2 days ago
Select JetBlue Airways flight, departing Wed, May 7 from Hyannis to San Diego, returning Sun, May 11, priced at $965 found 2 days ago
Flights from Hyannis (HYA) to San Diego (SAN)
Origin airport
Barnstable Municipal
Destination airport
San Diego Intl.
Roundtrip price
$758
Distance
2620 mi

Hyannis to San Diego Flights

The cheapest times to fly from Hyannis to San Diego

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Hyannis to San Diego are during the month of May. You can find some of the cheapest flights from Hyannis to San Diego with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Hyannis to San Diego

Sunday is one of the best days to book for cheap flights from Hyannis to San Diego: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Hyannis to San Diego

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Hyannis to San Diego in 2025. You can also book with separate airlines for your outbound and return journeys, from $172 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Hyannis to San Diego flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Hyannis to San Diego airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from Barnstable Municipal Airport (HYA) to San Diego Intl. Airport (SAN) cost?
Discover the latest flight deals from HYA to SAN by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from HYA to SAN?
The cheapest flights from HYA to SAN are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Barnstable Municipal Airport (HYA) to San Diego Intl. Airport (SAN)?
You can’t catch a direct flight from Hyannis, MA (HYA-Barnstable Municipal) to San Diego Intl. Airport (SAN). However, you can arrive in San Diego without any layovers by taking off from Logan Intl. Airport (BOS).
What is the cheapest airline that flies from HYA to SAN?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from HYA to SAN. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Barnstable Municipal Airport (HYA) to San Diego Intl. Airport (SAN)?
You’ll need to catch a flight with a layover when traveling from Barnstable Municipal Airport (HYA) to San Diego Intl. Airport (SAN). Direct flights don’t operate daily on this route. However, simply filter your search to include one or more stops to find an option that works for you.
What day of the week has the most flights from HYA to SAN?
Typically you’ll find the most flight options available on a Friday. Tuesdays are often the quietest.* But this can change depending on the season, airline and other factors.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Barnstable Municipal Airport (HYA) to San Diego Intl. Airport (SAN)?
To avoid possible delays on the Barnstable Municipal Airport (HYA) to San Diego Intl. Airport (SAN) route, fly before 3 PM. Later departures have a 22% higher chance of being canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Barnstable Municipal Airport (HYA) to San Diego Intl. Airport (SAN) last-minute?
Last-minute fares from HYA to SAN are typically more expensive. To secure the best rates, start searching for flights well ahead of time. That said, if you’re flexible with your travel dates, you may find a cheap ticket right before your trip.
Is it cheaper to book a HYA to SAN flight and hotel package?
Compared with arranging flights and hotels separately, booking a HYA to SAN flight and hotel package with Expedia could lead to significant savings. Better still, having everything in one convenient place will take the stress out of travel planning. Just secure your flights and select from our wide range of stays, then tailor your trip with other add-ons like tours, car rentals and activities.
Can I cancel or change the date of my flight from Barnstable Municipal Airport (HYA) to San Diego Intl. Airport (SAN)?
It’s usually possible to cancel or reschedule your HYA to SAN flight. However, if it’s been more than 24 hours since booking, additional charges may apply. Refer to your airline’s policies in your itinerary to see what changes are possible and whether any costs are involved. You’ll also find more details on our Customer Service portal.

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*Available to One Key members.