$291 Cheap Flights from Houston (HOU) to Santiago (SCL)

View $291 flight on Sat, Jun 28, 2025Opens in a new window
Find available prices by choosing your travel dates.

Cheap Flights from Houston to Santiago (HOU-SCL)

Prices were available within the past 7 days and start at $291 for one-way flights and $600 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

avianca
Thu, Sep 11 - Wed, Sep 24
IAH
Houston
SCL
Santiago
$600 Roundtrip, found 2 days ago
$600
Roundtrip
found 2 days ago
Select avianca flight, departing Thu, Sep 11 from Houston to Santiago, returning Wed, Sep 24, priced at $600 found 2 days ago
avianca
Sun, Jun 1 - Tue, Jun 3
IAH
Houston
SCL
Santiago
$612 Roundtrip, found 3 days ago
$612
Roundtrip
found 3 days ago
Select avianca flight, departing Sun, Jun 1 from Houston to Santiago, returning Tue, Jun 3, priced at $612 found 3 days ago
avianca
Tue, Jun 17 - Sun, Jun 29
IAH
Houston
SCL
Santiago
$614 Roundtrip, found 1 day ago
$614
Roundtrip
found 1 day ago
Select avianca flight, departing Tue, Jun 17 from Houston to Santiago, returning Sun, Jun 29, priced at $614 found 1 day ago
avianca
Thu, Sep 11 - Wed, Sep 24
IAH
Houston
SCL
Santiago
$617 Roundtrip, found 2 days ago
$617
Roundtrip
found 2 days ago
Select avianca flight, departing Thu, Sep 11 from Houston to Santiago, returning Wed, Sep 24, priced at $617 found 2 days ago
avianca
Sat, May 31 - Sat, Jul 26
IAH
Houston
SCL
Santiago
$619 Roundtrip, found 3 days ago
$619
Roundtrip
found 3 days ago
Select avianca flight, departing Sat, May 31 from Houston to Santiago, returning Sat, Jul 26, priced at $619 found 3 days ago
avianca
Tue, Jun 17 - Sun, Jun 29
IAH
Houston
SCL
Santiago
$626 Roundtrip, found 1 day ago
$626
Roundtrip
found 1 day ago
Select avianca flight, departing Tue, Jun 17 from Houston to Santiago, returning Sun, Jun 29, priced at $626 found 1 day ago
Air Canada
Mon, Jan 5 - Tue, Jan 20
IAH
Houston
SCL
Santiago
$1,162 Roundtrip, found 4 days ago
$1,162
Roundtrip
found 4 days ago
Select Air Canada flight, departing Mon, Jan 5 from Houston to Santiago, returning Tue, Jan 20, priced at $1,162 found 4 days ago
United
Thu, Jan 15 - Wed, Jan 28
IAH
Houston
SCL
Santiago
$1,349 Roundtrip, found 6 days ago
$1,349
Roundtrip
found 6 days ago
Select United flight, departing Thu, Jan 15 from Houston to Santiago, returning Wed, Jan 28, priced at $1,349 found 6 days ago
American Airlines
Tue, Jun 17 - Tue, Jun 24
IAH
Houston
SCL
Santiago
$1,364 Roundtrip, found 1 hour ago
$1,364
Roundtrip
found 1 hour ago
Select American Airlines flight, departing Tue, Jun 17 from Houston to Santiago, returning Tue, Jun 24, priced at $1,364 found 1 hour ago
Delta
Tue, Aug 5 - Tue, Aug 12
HOU
Houston
SCL
Santiago
$1,364 Roundtrip, found 3 hours ago
$1,364
Roundtrip
found 3 hours ago
Select Delta flight, departing Tue, Aug 5 from Houston to Santiago, returning Tue, Aug 12, priced at $1,364 found 3 hours ago
Flights from Houston (IAH) to Santiago (SCL)
Origin airport
George Bush Intercontinental
Destination airport
Arturo Merino Benitez
Airlines serving
American Airlines, Delta, LATAM Airlines Group
Roundtrip price
$600
Distance
4663 mi

Houston to Santiago Flights

The cheapest times to fly from Houston to Santiago

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Houston to Santiago are during the month of September. You can find some of the cheapest flights from Houston to Santiago with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Houston to Santiago

Sunday is one of the best days to book for cheap flights from Houston to Santiago: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Houston to Santiago

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Houston to Santiago in 2025. You can also book with separate airlines for your outbound and return journeys, from $291 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Houston to Santiago flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Houston to Santiago airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

How much does a flight from William P. Hobby Airport (HOU) to Arturo Merino Benitez Airport (SCL) cost?
Discover the latest flight deals from HOU to SCL by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from HOU to SCL?
The cheapest flights from HOU to SCL are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from William P. Hobby Airport (HOU) to Arturo Merino Benitez Airport (SCL)?
There are no direct flights from Houston, TX (HOU-William P. Hobby) to Arturo Merino Benitez Airport (SCL). However, you can find other airports that offer nonstop flights. Start your journey at George Bush Intercontinental Airport (IAH) and travel straight to Santiago without any detours.
What is the cheapest airline that flies from HOU to SCL?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from HOU to SCL. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from William P. Hobby Airport (HOU) to Arturo Merino Benitez Airport (SCL)?
Direct flights from William P. Hobby Airport (HOU) to Arturo Merino Benitez Airport (SCL) aren’t available daily, so you’ll need to take a flight with a layover. Explore your options with our filter tool. Enter your dates and select either “1 Stop” or “2+ Stops.”
What day of the week has the most flights from HOU to SCL?
Friday is generally the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can change based on a range of factors, such as the carrier and season.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from William P. Hobby Airport (HOU) to Arturo Merino Benitez Airport (SCL)?
To avoid possible delays on the William P. Hobby Airport (HOU) to Arturo Merino Benitez Airport (SCL) route, aim to travel before 3 PM. Departures after this hour have a 22% higher chance of cancellation.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from William P. Hobby Airport (HOU) to Arturo Merino Benitez Airport (SCL) last-minute?
Last-minute fares from HOU to SCL are typically more expensive. For the lowest prices, start searching for flights ahead of time. That said, if you’re flexible with your travel plans, you may find a cheap fare just before your departure.
Is it cheaper to book a HOU to SCL flight and hotel package?
Securing a HOU to SCL flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Pick from our impressive range of hotels and then add activities, car rentals and flights to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from William P. Hobby Airport (HOU) to Arturo Merino Benitez Airport (SCL)?
Usually, it’s possible to reschedule or cancel your HOU to SCL flight. However, if it’s been more than 24 hours since booking, additional charges may apply. Refer to your airline’s policies in your itinerary to see what changes are allowed and if any costs are involved. You’ll also find more information on our Customer Service portal.

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*Available to One Key members.