$153 Cheap Flights from Greenville (GSP) to Panama City (PTY)

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Find available prices by choosing your travel dates.

Cheap Flights from Greenville to Panama City (GSP-PTY)

Prices were available within the past 7 days and start at $153 for one-way flights and $371 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

United
American Airlines
Delta
United
United
American Airlines
Delta
American Airlines
American Airlines
Copa
Flights from Greenville (GSP) to Panama City (PTY)
Origin airport
Greenville-Spartanburg Intl.
Destination airport
Tocumen Intl.
Airlines serving
American Airlines, Copa, Delta, United
Roundtrip price
$371
Distance
1793 mi

Greenville to Panama City Flights

The cheapest times to fly from Greenville to Panama City

On average, Thursday can be the cheapest time to fly, according to data from the Airlines Reporting Corporation (ARC), one of the world's biggest databases for global airline sales. The data reveals that you could save up to 16% by flying on a Thursday—the cheapest day to travel on average—instead of a Sunday—the most expensive. Some of the most affordable flights from Greenville to Panama City are during the month of July. You can find some of the cheapest flights from Greenville to Panama City with Expedia's search tool and vast selection of airlines.

The best time to book a flight from Greenville to Panama City

Sunday is one of the best days to book for cheap flights from Greenville to Panama City: Tickets reserved on a Sunday cost between 6% and 13% less than those reserved on a Friday, according to ARC data. The data also suggests booking early can also lead to cheaper airfares. You could save 24% by buying your tickets for domestic flights at least a month in advance and 10% by booking international flights 2 months in advance.

How to find cheap round-trip tickets from Greenville to Panama City

Being flexible with your dates and using Expedia's Price Drop Protection and Price Tracking features are some of the best ways of finding a cheap ticket from Greenville to Panama City in 2025. You can also book with separate airlines for your outbound and return journeys, from $153 one-way. Expedia also offers Price Drop Protection, so if the cost of your airfare goes down after booking, you'll receive a credit for the difference*. This is available for a small fee, and is free to One Key Gold and Platinum tier members.

Expedia's Price Tracking feature means you can stay on top of airfares without manually checking every day. It sends you automated price alerts for cheap Greenville to Panama City flights and uses historical data to indicate when the best time to book is. Download Expedia's free app to activate this handy tool in a few easy taps.

You could also save big by booking one of Expedia's vacation packages. Bundling together your Greenville to Panama City airfare with your accommodations and car rental is often cheaper than booking everything separately. There’s also One Key, Expedia's generous rewards program. Join for free and you could earn One Key cash on most bookings to save on future adventures.

*Terms apply.

Disclaimer: ARC The statistics are based on average round-trip ticket prices between January and August 2023. The percentages you see are averages.

Frequently asked questions

Is it cheaper to buy a plane ticket from Roger Milliken Field to Panama Airport last minute?
When it’s time to book your flights, it’s better to be prepared. While you could find a deal on a Greenville-Spartanburg Intl. Airport (GSP) to Panama Airport flight at the last minute, fares usually don’t get cheaper as the date of departure nears. Based on flight pricing and demand studies in 2022, we have found that the sweet spot to lock in a domestic flight is between 28 – 35 days ahead. For international journeys it’s three to four months.
What airports do you fly into for Panama City from Greenville?
From Greenville, you can get to Panama City through Tocumen Intl. Airport (PTY), Marcos A. Gelabert Intl. Airport (PAC) and Panama Pacifico Intl. Airport (BLB). Determine which terminal is right for you before you make a decision. If you decide on Tocumen Intl. Airport (PTY), it’s around 11 mi northeast of downtown. Use the cash you save when booking your seat with Expedia to check out the city’s awesome sights, such as Miraflores Locks and Metropolitan Cathedral of Panama.
Can I change the date of my flight from Greenville-Spartanburg Intl. Airport (GSP) to PTY?
You can make changes to your GSP to PTY ticket through the Expedia Trips portal. Before you make any amendments, read the conditions in your itinerary to see what you’re allowed to do and what fees apply for changes. Some airlines charge a change fee per person, plus any difference in fare prices. However, if you booked in the last 24 hours, you may be able to cancel for free and organize new flights. You can also stop by our Customer Service portal to find the answers to your questions and to connect with our Virtual Agent.

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*Available to One Key members.