$218 Cheap Flights from Florence (FLO) to Tampa (TPA)

View $218 flight on Sat, Nov 8, 2025Opens in a new window

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Find available prices by choosing your travel dates.

Cheap Flights from Florence to Tampa (FLO-TPA)

Prices were available within the past 7 days and start at $218 for one-way flights and $387 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Tue, Jun 10 - Sat, Jun 14
FLO
Florence
TPA
Tampa
$387 Roundtrip, found 3 days ago
$387
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jun 10 from Florence to Tampa, returning Sat, Jun 14, priced at $387 found 3 days ago
American Airlines
Tue, May 6 - Tue, May 13
FLO
Florence
TPA
Tampa
$407 Roundtrip, found 5 days ago
$407
Roundtrip
found 5 days ago
Select American Airlines flight, departing Tue, May 6 from Florence to Tampa, returning Tue, May 13, priced at $407 found 5 days ago
American Airlines
Tue, Jun 3 - Thu, Jun 5
FLO
Florence
TPA
Tampa
$411 Roundtrip, found 8 hours ago
$411
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Tue, Jun 3 from Florence to Tampa, returning Thu, Jun 5, priced at $411 found 8 hours ago
American Airlines
Sat, Jun 21 - Sun, Jun 29
FLO
Florence
TPA
Tampa
$421 Roundtrip, found 6 days ago
$421
Roundtrip
found 6 days ago
Select American Airlines flight, departing Sat, Jun 21 from Florence to Tampa, returning Sun, Jun 29, priced at $421 found 6 days ago
American Airlines
Thu, Jun 26 - Sun, Jun 29
FLO
Florence
TPA
Tampa
$435 Roundtrip, just found
$435
Roundtrip
just found
Select American Airlines flight, departing Thu, Jun 26 from Florence to Tampa, returning Sun, Jun 29, priced at $435 just found
American Airlines
Wed, Sep 10 - Sat, Sep 13
FLO
Florence
TPA
Tampa
$447 Roundtrip, found 8 hours ago
$447
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Wed, Sep 10 from Florence to Tampa, returning Sat, Sep 13, priced at $447 found 8 hours ago
American Airlines
Tue, Jun 10 - Sat, Jun 14
FLO
Florence
TPA
Tampa
$450 Roundtrip, found 3 days ago
$450
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, Jun 10 from Florence to Tampa, returning Sat, Jun 14, priced at $450 found 3 days ago
American Airlines
Tue, May 20 - Tue, May 27
FLO
Florence
TPA
Tampa
$457 Roundtrip, found 3 days ago
$457
Roundtrip
found 3 days ago
Select American Airlines flight, departing Tue, May 20 from Florence to Tampa, returning Tue, May 27, priced at $457 found 3 days ago
American Airlines
Thu, Sep 11 - Sat, Sep 13
FLO
Florence
TPA
Tampa
$462 Roundtrip, found 8 hours ago
$462
Roundtrip
found 8 hours ago
Select American Airlines flight, departing Thu, Sep 11 from Florence to Tampa, returning Sat, Sep 13, priced at $462 found 8 hours ago
American Airlines
Sun, Oct 26 - Fri, Oct 31
FLO
Florence
TPA
Tampa
$465 Roundtrip, found 14 hours ago
$465
Roundtrip
found 14 hours ago
Select American Airlines flight, departing Sun, Oct 26 from Florence to Tampa, returning Fri, Oct 31, priced at $465 found 14 hours ago

Frequently asked questions

How much does a flight from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA) cost?
Discover the latest flight deals from FLO to TPA by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from FLO to TPA?
The cheapest flights from FLO to TPA are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
Which airlines fly direct from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
Direct flights aren’t available from Florence, SC (FLO-Florence Regional) to Tampa Intl. Airport (TPA). However, you can find other airports offering nonstop flights. Start your journey at Myrtle Beach Intl. Airport (MYR) and fly straight to Tampa without any detours.
What is the cheapest airline that flies from FLO to TPA?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from FLO to TPA. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
There aren’t any daily direct flights departing from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA). But you can opt for flights with layovers. Filter your search on Expedia to include one or two stops, and you’ll be soaring above the clouds in no time at all.
What day of the week has the most flights from FLO to TPA?
You’ll generally find Tuesday the quietest day for flights, while Fridays tend to be the busiest.* However this can vary from season to season and during peak travel times or public holidays.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
Select a flight from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA) that takes off before 3 PM to reduce the risk of cancellations and delays. Departures later than this are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA) last-minute?
Waiting until just before your departure to book your flight from FLO to TPA often results in higher prices. While you might find some last-minute deals, there’s no guarantee. Allow some flexibility in your schedule to maximize your chances of getting a bargain.
Is it cheaper to book a FLO to TPA flight and hotel package?
You can save money by booking a FLO to TPA flight and hotel package compared to booking separately. In fact, travelers could save hundreds of dollars by bundling with Expedia. And it’s simple to manage it all in one convenient place. Once you’ve chosen your ideal accommodations and flights, consider adding extras like tours, activities and car rentals.
Can I cancel or change the date of my flight from Florence Regional Airport (FLO) to Tampa Intl. Airport (TPA)?
Typically, you can modify or cancel your FLO to TPA flight. However, there may be additional charges, especially if your booking was made more than 24 hours ago. Double-check your itinerary for the airline’s fees and guidelines on flight changes, or if you’d like further details, go to our Customer Service portal.
*Available to One Key members.