$144 Cheap Flights from Panama City (ECP) to Knoxville (TYS)

View $144 flight on Wed, May 28, 2025Opens in a new window

Popular airlines from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)

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Find available prices by choosing your travel dates.

Cheap Flights from Panama City to Knoxville (ECP-TYS)

Prices were available within the past 7 days and start at $144 for one-way flights and $287 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Fri, May 30 - Sat, May 31
ECP
Panama City
TYS
Knoxville
$287 Roundtrip, found 16 hours ago
$287
Roundtrip
found 16 hours ago
Select Delta flight, departing Fri, May 30 from Panama City to Knoxville, returning Sat, May 31, priced at $287 found 16 hours ago
Delta
Fri, May 30 - Tue, Jun 10
ECP
Panama City
TYS
Knoxville
$317 Roundtrip, found 15 hours ago
$317
Roundtrip
found 15 hours ago
Select Delta flight, departing Fri, May 30 from Panama City to Knoxville, returning Tue, Jun 10, priced at $317 found 15 hours ago
Delta
Fri, May 30 - Fri, Jun 13
ECP
Panama City
TYS
Knoxville
$327 Roundtrip, found 15 hours ago
$327
Roundtrip
found 15 hours ago
Select Delta flight, departing Fri, May 30 from Panama City to Knoxville, returning Fri, Jun 13, priced at $327 found 15 hours ago
Delta
Fri, May 16 - Wed, May 28
ECP
Panama City
TYS
Knoxville
$337 Roundtrip, found 1 day ago
$337
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, May 16 from Panama City to Knoxville, returning Wed, May 28, priced at $337 found 1 day ago
Delta
Wed, Jun 4 - Tue, Jun 10
ECP
Panama City
TYS
Knoxville
$347 Roundtrip, found 15 hours ago
$347
Roundtrip
found 15 hours ago
Select Delta flight, departing Wed, Jun 4 from Panama City to Knoxville, returning Tue, Jun 10, priced at $347 found 15 hours ago
Delta
Fri, Jul 18 - Tue, Jul 22
ECP
Panama City
TYS
Knoxville
$357 Roundtrip, found 7 hours ago
$357
Roundtrip
found 7 hours ago
Select Delta flight, departing Fri, Jul 18 from Panama City to Knoxville, returning Tue, Jul 22, priced at $357 found 7 hours ago
American Airlines
Thu, Jul 24 - Mon, Jul 28
ECP
Panama City
TYS
Knoxville
$367 Roundtrip, found 5 hours ago
$367
Roundtrip
found 5 hours ago
Select American Airlines flight, departing Thu, Jul 24 from Panama City to Knoxville, returning Mon, Jul 28, priced at $367 found 5 hours ago
Delta
Fri, May 16 - Sun, Jun 1
ECP
Panama City
TYS
Knoxville
$377 Roundtrip, found 1 day ago
$377
Roundtrip
found 1 day ago
Select Delta flight, departing Fri, May 16 from Panama City to Knoxville, returning Sun, Jun 1, priced at $377 found 1 day ago
American Airlines
Fri, May 30 - Sat, Jun 14
ECP
Panama City
TYS
Knoxville
$387 Roundtrip, found 15 hours ago
$387
Roundtrip
found 15 hours ago
Select American Airlines flight, departing Fri, May 30 from Panama City to Knoxville, returning Sat, Jun 14, priced at $387 found 15 hours ago
United
Mon, May 5 - Mon, May 12
ECP
Panama City
TYS
Knoxville
$644 Roundtrip, found 3 days ago
$644
Roundtrip
found 3 days ago
Select United flight, departing Mon, May 5 from Panama City to Knoxville, returning Mon, May 12, priced at $644 found 3 days ago

Frequently asked questions

How much does a flight from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS) cost?
Discover the latest flight deals from ECP to TYS by entering your preferred travel dates and searching on Expedia. Easily compare prices by departure date if you have flexibility with your schedule and use handy filters to explore prices for your preferred journey. As a member of One Key™, our free loyalty program, you can use Price Tracking to watch fares and receive notifications if prices go up or down.
What is the cheapest month to fly from ECP to TYS?
The cheapest flights from ECP to TYS are usually during off-peak season, when demand is lower. To save money, avoid flying during public holidays, school breaks and major local events.
What is the cheapest airline that flies from ECP to TYS?
Use the filter tool on Expedia to compare airlines and find the cheapest carrier that’ll take you from ECP to TYS. Sort your results by “Price (lowest to highest)” to snap up a great deal.
How many flights per day from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)?
There are no daily nonstop flights from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS). But you can book flights with layovers. Filter your search results on Expedia to include one or two stops, and you’ll be soaring above the clouds in no time at all.
What day of the week has the most flights from ECP to TYS?
Friday is usually the busiest day for flights, while Tuesday is often the quietest.* Remember that flight schedules can vary depending on a range of factors, such as the time of year and airline.*Busiest/quietest day to travel is based on Expedia flight demand through January to December 2024.
What is the best time to fly from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)?
Book a flight from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS) that leaves before 3 PM to reduce the risk of delays and cancellations. Departures after this time are on average 22% more likely to be canceled.**Most reliable time of the day and month to travel recommendation is based on January through August 2024 flight status data sourced from OAG’s global flight data platform.
Is it cheaper to buy a plane ticket from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS) last-minute?
Waiting until right before your break to book a ticket from ECP to TYS generally means paying more. While you may find some last-minute deals, they’re not always guaranteed. Keep your travel schedule open for a better chance of scoring a bargain.
Is it cheaper to book an ECP to TYS flight and hotel package?
Opting for an ECP to TYS flight and hotel package is typically cheaper than booking separately. With Expedia, you can enjoy the convenience of organizing your travels all in one place. Select from our wide range of hotels and then add activities, flights and car rentals to your booking. Bundle it all together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Northwest Florida Beaches Intl. Airport (ECP) to McGhee Tyson Airport (TYS)?
If you booked your ECP to TYS flight within the last 24 hours, you may be able to modify or cancel it at no cost. Depending on the airline and the type of fare you purchased, additional charges may apply for changes beyond that time. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you want more information.
*Available to One Key members.